hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13864.1

Complex Portal: CPX-19288

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
NPRL2	GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4)	5	UniProt NCBI
ZNF414	Zinc finger protein 414	5	UniProt NCBI
KPTN	KICSTOR complex protein kaptin (Actin-associated protein 2E4)	5	UniProt NCBI
ITFG2	KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2)	5	UniProt NCBI
TNFAIP8L2	Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20)	5	UniProt NCBI
SHMT1	Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)	5	UniProt NCBI
NPRL3	GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)	5	UniProt NCBI
TES	Testin (TESS)	5	UniProt NCBI
KICS2	KICSTOR subunit 2 (KICSTOR complex protein C12orf66)	5	UniProt NCBI
TMCO4	Transmembrane and coiled-coil domain-containing protein 4	3	UniProt NCBI
BMT2	S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-)	5	UniProt NCBI
SZT2	KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog)	5	UniProt NCBI
DEPDC5	GATOR1 complex protein DEPDC5 (DEP domain-containing protein 5)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9639288	5.96618362092e-15	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	Amino acids regulate mTORC1
GO:1904262	1.4588343597e-13	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	negative regulation of TORC1 signaling
GO:0034198	1.7917358052e-13	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	cellular response to amino acid starvation
GO:1990928	2.66176720688e-13	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	response to amino acid starvation
GO:0032007	2.72658285307e-12	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	negative regulation of TOR signaling
CORUM:6754	2.11387990692e-11	0.307692307692	KICS2 KPTN SZT2 ITFG2	KICSTOR complex
REAC:R-HSA-9711097	4.03661002408e-11	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	Cellular response to starvation
GO:1903432	5.87054108448e-11	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	regulation of TORC1 signaling
GO:0038202	8.60479952909e-11	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	TORC1 signaling
GO:0009267	9.46771828758e-10	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	cellular response to starvation
GO:0032006	1.32701633706e-09	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	regulation of TOR signaling
GO:0042594	2.82630119499e-09	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	response to starvation
GO:0031929	3.18433486196e-09	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	TOR signaling
GO:0031669	1.11829601434e-08	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	cellular response to nutrient levels
GO:0031668	1.73966070327e-08	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	cellular response to extracellular stimulus
GO:0140007	1.88135311715e-08	0.307692307692	KICS2 KPTN SZT2 ITFG2	KICSTOR complex
CORUM:6215	3.08880131998e-08	0.230769230769	NPRL2 NPRL3 DEPDC5	GATOR1 complex
GO:0071496	7.61425602554e-08	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	cellular response to external stimulus
GO:1990130	9.40213012535e-08	0.307692307692	NPRL2 DEPDC5 NPRL3 SZT2	GATOR1 complex
GO:0031667	1.34994225368e-07	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	response to nutrient levels
GO:0009991	2.00368344548e-07	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	response to extracellular stimulus
CORUM:6217	1.72529396443e-06	0.230769230769	NPRL2 NPRL3 DEPDC5	GATOR complex
CORUM:6753	1.72529396443e-06	0.230769230769	NPRL2 NPRL3 SZT2	SOG complex
REAC:R-HSA-2262752	9.73352893993e-06	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	Cellular responses to stress
REAC:R-HSA-8953897	1.04940747513e-05	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	Cellular responses to stimuli
HP:0012005	1.14366758996e-05	0.230769230769	NPRL2 NPRL3 DEPDC5	Deja vu aura
HP:0012004	1.14366758996e-05	0.230769230769	NPRL2 NPRL3 DEPDC5	Focal cognitive seizure with deja vu/jamais vu
HP:0032680	1.14366758996e-05	0.230769230769	NPRL2 NPRL3 DEPDC5	Focal cognitive seizure
GO:0035859	1.33921251982e-05	0.307692307692	NPRL2 DEPDC5 NPRL3 SZT2	Seh1-associated complex
GO:1902532	1.39932397914e-05	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	negative regulation of intracellular signal transduction
HP:0008765	2.00039093777e-05	0.230769230769	NPRL2 NPRL3 DEPDC5	Auditory hallucination
HP:0033346	4.7960106411e-05	0.230769230769	NPRL2 NPRL3 DEPDC5	Psychic epileptic aura
HP:0012002	4.7960106411e-05	0.230769230769	NPRL2 NPRL3 DEPDC5	Experiential epileptic aura
HP:0002427	9.4110654937e-05	0.230769230769	NPRL2 NPRL3 DEPDC5	Expressive aphasia
GO:0098852	0.00019707828691	0.538461538462	SZT2 ITFG2 DEPDC5 NPRL3 NPRL2 KICS2 KPTN	lytic vacuole membrane
GO:0005765	0.00019707828691	0.538461538462	SZT2 ITFG2 DEPDC5 NPRL3 NPRL2 KICS2 KPTN	lysosomal membrane
HP:0007206	0.000207294223637	0.230769230769	NPRL2 NPRL3 DEPDC5	Hemimegalencephaly
HP:0031951	0.000207294223637	0.230769230769	NPRL2 NPRL3 DEPDC5	Nocturnal seizures
HP:0032046	0.000207294223637	0.230769230769	NPRL2 NPRL3 DEPDC5	Focal cortical dysplasia
HP:0033259	0.000257003861069	0.384615384615	NPRL2 DEPDC5 SZT2 NPRL3 KPTN	Non-motor seizure
HP:0002367	0.000258984750461	0.230769230769	NPRL2 NPRL3 DEPDC5	Visual hallucination
GO:0005774	0.000335639614267	0.538461538462	SZT2 ITFG2 DEPDC5 NPRL3 NPRL2 KICS2 KPTN	vacuolar membrane
HP:0033348	0.000550420302517	0.230769230769	NPRL2 NPRL3 DEPDC5	Epileptic aura
HP:0011146	0.000729907485385	0.384615384615	NPRL2 DEPDC5 SZT2 NPRL3 KPTN	Dialeptic seizure
HP:0011171	0.000754703244566	0.230769230769	NPRL2 NPRL3 DEPDC5	Simple febrile seizure
HP:0002349	0.000754703244566	0.230769230769	NPRL2 NPRL3 DEPDC5	Focal aware seizure
HP:0032052	0.000760826170135	0.153846153846	DEPDC5 NPRL3	Focal cortical dysplasia type IIa
GO:0042149	0.00168910935121	0.307692307692	KICS2 KPTN SZT2 ITFG2	cellular response to glucose starvation
GO:0048585	0.00211783150724	0.692307692308	SZT2 BMT2 ITFG2 DEPDC5 TNFAIP8L2 NPRL3 NPRL2 KICS2 KPTN	negative regulation of response to stimulus
HP:0032679	0.00337299830807	0.230769230769	NPRL2 NPRL3 DEPDC5	Focal non-motor seizure
HP:0001355	0.00437296709122	0.230769230769	NPRL2 NPRL3 DEPDC5	Megalencephaly
HP:0002069	0.00648083740377	0.384615384615	NPRL2 DEPDC5 SZT2 NPRL3 KPTN	Bilateral tonic-clonic seizure
HP:0031284	0.00742698234727	0.230769230769	NPRL2 NPRL3 DEPDC5	Flushing
HP:0032051	0.00759681327472	0.153846153846	DEPDC5 NPRL3	Focal cortical dysplasia type II
GO:0009968	0.00843737041646	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	negative regulation of signal transduction
HP:0002521	0.00863095936268	0.307692307692	NPRL2 DEPDC5 NPRL3 SZT2	Hypsarrhythmia
GO:0000323	0.00959102104409	0.538461538462	SZT2 ITFG2 DEPDC5 NPRL3 NPRL2 KICS2 KPTN	lytic vacuole
GO:0005764	0.00959102104409	0.538461538462	SZT2 ITFG2 DEPDC5 NPRL3 NPRL2 KICS2 KPTN	lysosome
WP:WP4657	0.00988091201976	0.230769230769	NPRL2 NPRL3 DEPDC5	22q11 2 copy number variation syndrome
GO:0010648	0.0108363006545	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	negative regulation of cell communication
GO:0023057	0.0114002603604	0.615384615385	SZT2 DEPDC5 ITFG2 BMT2 NPRL3 NPRL2 KICS2 KPTN	negative regulation of signaling
HP:0002539	0.0116363302376	0.230769230769	NPRL2 NPRL3 DEPDC5	Cortical dysplasia
KEGG:04150	0.0154550895581	0.230769230769	NPRL2 NPRL3 DEPDC5	mTOR signaling pathway
GO:0005773	0.0184970210202	0.538461538462	SZT2 ITFG2 DEPDC5 NPRL3 NPRL2 KICS2 KPTN	vacuole
HP:0010841	0.0200069455336	0.230769230769	NPRL2 NPRL3 DEPDC5	Multifocal epileptiform discharges
GO:0009605	0.0284011726291	0.692307692308	SZT2 BMT2 ITFG2 DEPDC5 TNFAIP8L2 NPRL3 NPRL2 KICS2 KPTN	response to external stimulus
HP:0002353	0.0318519025447	0.384615384615	NPRL2 DEPDC5 SZT2 NPRL3 KPTN	EEG abnormality
HP:0011198	0.0418771958629	0.307692307692	NPRL2 DEPDC5 NPRL3 SZT2	EEG with generalized epileptiform discharges
HP:0030178	0.0427991177882	0.384615384615	NPRL2 DEPDC5 SZT2 NPRL3 KPTN	Abnormality of central nervous system electrophysiology

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
KPTN	ITFG2	1.0	0.234	structurally_consistent (dimer)
NPRL2	DEPDC5	1.0	0.138
SZT2	ITFG2	1.0	0.156
KPTN	SZT2	1.0	0.17
KICS2	ITFG2	0.999	0.134
NPRL2	NPRL3	0.999	0.138
KPTN	TMCO4	0.999	0.082	structurally_consistent (dimer)
KPTN	KICS2	0.999	0.082
BMT2	DEPDC5	0.997
BMT2	SZT2	0.997
BMT2	KICS2	0.996
DEPDC5	NPRL3	0.996	0.118
NPRL2	BMT2	0.995
NPRL2	ZNF414	0.993	0.116
KICS2	SZT2	0.989	0.066
DEPDC5	ZNF414	0.989	0.122
BMT2	ITFG2	0.987		structurally_consistent (dimer)
BMT2	NPRL3	0.98
KPTN	NPRL3	0.978	0.222
NPRL2	ITFG2	0.978	0.15
NPRL3	ZNF414	0.972	0.172
KPTN	TES	0.972	0.038	structurally_consistent (dimer)
ITFG2	TMCO4	0.967	0.124	structurally_consistent (Q9Y664)
SZT2	TMCO4	0.962	0.132
KICS2	TMCO4	0.961	0.064
DEPDC5	ITFG2	0.959	0.108
KPTN	BMT2	0.933		structurally_consistent (Q969R8) structurally_consistent (dimer)
NPRL2	SHMT1	0.93	0.112
ITFG2	NPRL3	0.92	0.178
TES	TNFAIP8L2	0.908	0.078
BMT2	SHMT1	0.883
TES	KICS2	0.855	0.066
TES	TMCO4	0.852	0.11
KPTN	NPRL2	0.657	0.142
NPRL2	SZT2	0.65	0.104
NPRL2	KICS2	0.648	0.104
KICS2	NPRL3	0.636	0.114
KPTN	DEPDC5	0.606	0.068
TES	SZT2	0.606	0.074
SZT2	NPRL3	0.6	0.156
DEPDC5	KICS2	0.576	0.112
NPRL3	SHMT1	0.521	0.074
DEPDC5	SHMT1	0.346	0.05
KICS2	SHMT1	0.318	0.042
DEPDC5	SZT2	0.247	0.202
KPTN	SHMT1	0.182	0.036
TES	ITFG2	0.156	0.076	structurally_consistent (Q9Y664)
ITFG2	SHMT1	0.133	0.06
SZT2	SHMT1	0.123	0.074
TMCO4	NPRL3	0.016	0.134
TES	NPRL2	0.009	0.1
TES	SHMT1	0.006	0.052
TES	NPRL3	0.005	0.074

Related Complexes

Genename	Complexes
NPRL2	huMAP3_03530.1 huMAP3_07128.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
ZNF414	huMAP3_12562.1 huMAP3_13864.1
KPTN	huMAP3_00925.1 huMAP3_03857.1 huMAP3_05863.1 huMAP3_06146.1 huMAP3_06545.1 huMAP3_07900.1 huMAP3_09557.1 huMAP3_10405.1 huMAP3_10779.1 huMAP3_13864.1 huMAP3_15270.1
ITFG2	huMAP3_04172.1 huMAP3_07402.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
TNFAIP8L2	huMAP3_12962.1 huMAP3_13864.1
SHMT1	huMAP3_08187.1 huMAP3_13864.1
NPRL3	huMAP3_07128.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
TES	huMAP3_02842.1 huMAP3_02997.1 huMAP3_07456.1 huMAP3_10281.1 huMAP3_13864.1 huMAP3_14442.1
KICS2	huMAP3_04172.1 huMAP3_07402.1 huMAP3_08734.1 huMAP3_09557.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
TMCO4	huMAP3_04172.1 huMAP3_06146.1 huMAP3_06545.1 huMAP3_09557.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
BMT2	huMAP3_03530.1 huMAP3_07128.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
SZT2	huMAP3_04172.1 huMAP3_07402.1 huMAP3_08734.1 huMAP3_09557.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1
DEPDC5	huMAP3_03530.1 huMAP3_07128.1 huMAP3_08734.1 huMAP3_09179.1 huMAP3_10405.1 huMAP3_13864.1 huMAP3_15270.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13864.1

Complex Portal: CPX-19288