hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13865.1

Complex Portal: CPX-23461

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
TSEN54	tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)	5	UniProt NCBI
TSEN15	tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)	5	UniProt NCBI
GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)	5	UniProt NCBI
TSEN2	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	5	UniProt NCBI
TSEN34	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	5	UniProt NCBI
ARL4C	ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like protein 7) (ADP-ribosylation factor-like protein LAK)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5283	4.80104919782e-12	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	tRNA splicing endonuclease
HP:0006850	9.10622366424e-11	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the ventral pons
HP:0012765	9.10622366424e-11	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Widened cerebellar subarachnoid space
HP:0200049	4.24864026057e-10	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Upper limb hypertonia
HP:0003558	2.00227230606e-09	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Viral infection-induced rhabdomyolysis
HP:0031162	3.00307944538e-09	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Impaired oropharyngeal swallow response
HP:0002268	1.44311403782e-08	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Paroxysmal dystonia
HP:0011171	3.62741681089e-08	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Simple febrile seizure
HP:0006895	2.47683758208e-07	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Lower limb hypertonia
REAC:R-HSA-6784531	4.92132752099e-07	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	tRNA processing in the nucleus
HP:0200136	4.97527687074e-07	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Oral-pharyngeal dysphagia
HP:0012704	4.97527687074e-07	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Widened subarachnoid space
HP:0003201	4.97527687074e-07	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Rhabdomyolysis
HP:0025190	5.52747893676e-07	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Bilateral tonic-clonic seizure with generalized onset
HP:0006989	6.12437222557e-07	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Dysplastic corpus callosum
HP:0009062	6.76830028994e-07	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Infantile axial hypotonia
GO:0000379	1.92240082153e-06	0.5	TSEN2 TSEN54 TSEN34	tRNA-type intron splice site recognition and cleavage
HP:0007598	2.05938628571e-06	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Bilateral single transverse palmar creases
REAC:R-HSA-72306	5.40567812429e-06	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	tRNA processing
HP:0012703	7.72911213095e-06	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal subarachnoid space morphology
HP:0002365	8.5914184351e-06	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the brainstem
HP:0007362	8.5914184351e-06	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Aplasia/Hypoplasia of the brainstem
HP:0012110	8.5914184351e-06	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the pons
HP:0000253	1.10619803591e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Progressive microcephaly
HP:0011471	1.33933987353e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Gastrostomy tube feeding in infancy
HP:0007361	2.1709105889e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal pons morphology
HP:0001266	2.76156062683e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Choreoathetosis
HP:0002373	4.14701460682e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Febrile seizure (within the age range of 3 months to 6 years)
HP:0032892	4.14701460682e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Infection-related seizure
HP:0032894	4.14701460682e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Seizure precipitated by febrile infection
CORUM:5284	5.12534978153e-05	0.333333333333	TSEN2 TSEN54	RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
HP:0002123	5.26471526401e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Generalized myoclonic seizure
HP:0002033	5.80703630675e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Poor suck
HP:0012469	7.23437614755e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Infantile spasms
HP:0002509	9.70943935954e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Limb hypertonia
HP:0100704	9.98774586679e-05	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Cerebral visual impairment
HP:0002305	0.000108585441918	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Athetosis
HP:0002350	0.000117849197495	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Cerebellar cyst
HP:0032677	0.000181977153209	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Generalized-onset motor seizure
HP:0000340	0.000186422258545	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Sloping forehead
HP:0011097	0.000214821197194	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Epileptic spasm
HP:0005484	0.00024085827978	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Secondary microcephaly
HP:0008947	0.000246336384991	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Infantile muscular hypotonia
HP:0033454	0.000263330451525	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Tube feeding
HP:0000954	0.000275136646833	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Single transverse palmar crease
HP:0010576	0.00029358213002	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Intracranial cystic lesion
HP:0030724	0.000306382300887	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Central nervous system cyst
GO:0006388	0.000316805542726	0.5	TSEN2 TSEN54 TSEN34	tRNA splicing, via endonucleolytic cleavage and ligation
HP:0011344	0.000319595043117	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Severe global developmental delay
GO:0000394	0.00042234232358	0.5	TSEN2 TSEN54 TSEN34	RNA splicing, via endonucleolytic cleavage and ligation
HP:0002104	0.000432732940705	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Apnea
HP:0002072	0.000467390235865	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Chorea
HP:0032794	0.000513579459096	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Myoclonic seizure
HP:0010490	0.00056309605028	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormality of the palmar creases
HP:0001018	0.000616094424	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal palmar dermatoglyphics
HP:0002438	0.000708528962297	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Cerebellar malformation
HP:0001446	0.000720771307716	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormality of the musculature of the upper limbs
HP:0002363	0.000880329333254	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal brainstem morphology
HP:0001320	0.0010004397381	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Cerebellar vermis hypoplasia
HP:0031828	0.00103228693258	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal superficial reflex
HP:0003487	0.00103228693258	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Babinski sign
HP:0007477	0.00133447654341	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal dermatoglyphics
HP:0006817	0.00141424765083	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Aplasia/Hypoplasia of the cerebellar vermis
HP:0008936	0.00154050710701	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Axial hypotonia
HP:0007308	0.00161951205762	0.333333333333	TSEN2 TSEN54	Extrapyramidal dyskinesia
HP:0002197	0.00167499082336	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Generalized-onset seizure
HP:0002334	0.00254566164229	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal cerebellar vermis morphology
HP:0002069	0.00280786336649	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Bilateral tonic-clonic seizure
HP:0002536	0.00327620273234	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal cortical gyration
HP:0040211	0.00331449044449	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal skin morphology of the palm
HP:0020219	0.00487774652338	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Motor seizure
HP:0007256	0.00513919491307	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal pyramidal sign
HP:0001321	0.00660611471141	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Cerebellar hypoplasia
HP:0002079	0.00693330736043	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the corpus callosum
GO:0000213	0.00702301080125	0.333333333333	TSEN2 TSEN34	tRNA-intron endonuclease activity
HP:0002360	0.00741144488892	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Sleep abnormality
HP:0002269	0.00741144488892	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormality of neuronal migration
HP:0100871	0.00755244983316	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal palm morphology
HP:0002020	0.00875352451043	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Gastroesophageal reflux
HP:0002015	0.00957293852025	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Dysphagia
HP:0001332	0.0101795325916	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Dystonia
HP:0011356	0.0103579739901	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Regional abnormality of skin
HP:0007360	0.0116729789752	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Aplasia/Hypoplasia of the cerebellum
REAC:R-HSA-8953854	0.0121605407448	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Metabolism of RNA
HP:0007663	0.0136512113701	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Reduced visual acuity
HP:0008872	0.0156231225336	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Feeding difficulties in infancy
GO:0000214	0.0210651876021	0.333333333333	TSEN2 TSEN54	tRNA-intron endonuclease complex
HP:0009127	0.022019943452	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormality of the musculature of the limbs
HP:0002793	0.0389345128744	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal pattern of respiration
HP:0002119	0.0474661990519	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Ventriculomegaly
HP:0007370	0.0494403483522	0.666666666667	TSEN15 TSEN54 TSEN34 TSEN2	Aplasia/Hypoplasia of the corpus callosum

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TSEN15	TSEN34	1.0	0.22		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction
TSEN15	TSEN2	0.999	0.084	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN34	0.999	0.108		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN54	0.999	0.116	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN15	TSEN54	0.994	0.098	structurally_consistent (Q8NCE0)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ARL4C	GADD45A	0.982			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TSEN34	TSEN54	0.971	0.156		bioplex_WMM bioplex3_WMM WMM_only
ARL4C	TSEN54	0.969	0.104		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ARL4C	TSEN34	0.917	0.118		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ARL4C	TSEN2	0.809	0.08		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GADD45A	TSEN2	0.632			bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
GADD45A	TSEN54	0.489			bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
GADD45A	TSEN34	0.17			bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
TSEN54	huMAP3_04582.1 huMAP3_06042.1 huMAP3_07243.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN15	huMAP3_02940.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14576.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_15245.1
GADD45A	huMAP3_01737.1 huMAP3_01965.1 huMAP3_05425.1 huMAP3_07243.1 huMAP3_07720.1 huMAP3_07918.1 huMAP3_10622.1 huMAP3_12847.1 huMAP3_13865.1 huMAP3_14298.1 huMAP3_14586.1 huMAP3_14839.1
TSEN2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN34	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
ARL4C	huMAP3_01199.1 huMAP3_07243.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13865.1

Complex Portal: CPX-23461