hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13879.1

Complex Portal: CPX-24878

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
CXCL1	Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)]	5	UniProt NCBI
DIABLO	Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]	5	UniProt NCBI
HTRA2	Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)	5	UniProt NCBI
BCL10	B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10)	5	UniProt NCBI
BIRC3	Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)	5	UniProt NCBI
TBKBP1	TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1)	5	UniProt NCBI
IRAK3	Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)	5	UniProt NCBI
TRAF5	TNF receptor-associated factor 5 (RING finger protein 84)	5	UniProt NCBI
TRAF2	TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)	5	UniProt NCBI
BBOX1	Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)	5	UniProt NCBI
AZI2	5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP)	5	UniProt NCBI
BIRC2	Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)	5	UniProt NCBI
CXCL2	C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]	5	UniProt NCBI
CXCL3	C-X-C motif chemokine 3 (GRO-gamma(1-73)) (Growth-regulated protein gamma) (GRO-gamma) (Macrophage inflammatory protein 2-beta) (MIP2-beta) [Cleaved into: GRO-gamma(5-73)]	5	UniProt NCBI
SYCN	Syncollin (Insulin synthesis-associated protein 1)	2	UniProt NCBI
TANK	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)	5	UniProt NCBI
TBK1	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)	5	UniProt NCBI
TRAF1	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)	5	UniProt NCBI
IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0071345	1.17673370122e-12	0.764705882353	IKBKE TBK1 TRAF5 AZI2 BIRC2 TRAF2 TRAF1 CXCL1 BIRC3 HTRA2 TBKBP1 IRAK3 TANK	cellular response to cytokine stimulus
CORUM:5212	2.66142783093e-12	0.294117647059	AZI2 TBKBP1 TBK1 TANK TRAF2	Kinase maturation complex 2
GO:0019221	4.02799571887e-12	0.705882352941	IKBKE TRAF5 TBK1 BIRC2 TRAF2 TRAF1 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	cytokine-mediated signaling pathway
GO:0034097	5.47518030996e-12	0.764705882353	IKBKE TBK1 TRAF5 AZI2 BIRC2 TRAF2 TRAF1 CXCL1 BIRC3 HTRA2 TBKBP1 IRAK3 TANK	response to cytokine
GO:0007249	8.76238678482e-12	0.647058823529	IKBKE TRAF5 BIRC2 AZI2 TRAF1 TBK1 BIRC3 TRAF2 TBKBP1 TANK BCL10	canonical NF-kappaB signal transduction
KEGG:04621	1.11110471481e-10	0.470588235294	TANK TBK1 TRAF2 CXCL1 BIRC3 IKBKE BIRC2 TRAF5	NOD-like receptor signaling pathway
KEGG:04064	1.263865755e-10	0.411764705882	TRAF5 TRAF2 CXCL1 BIRC3 TRAF1 BIRC2 BCL10	NF-kappa B signaling pathway
WP:WP231	3.38701328206e-10	0.411764705882	TANK TRAF2 TBK1 BIRC3 TRAF1 BIRC2 DIABLO	TNF alpha signaling pathway
REAC:R-HSA-5357905	2.03369905715e-09	0.352941176471	IKBKE TRAF2 TBK1 BIRC3 TRAF1 BIRC2	Regulation of TNFR1 signaling
WP:WP3865	2.60427419466e-09	0.352941176471	IKBKE AZI2 TBK1 TRAF2 TBKBP1 TANK	Novel intracellular components of RIG I like receptor pathway
KEGG:04622	4.38925159384e-09	0.352941176471	IKBKE AZI2 TBK1 TRAF2 TBKBP1 TANK	RIG-I-like receptor signaling pathway
GO:0071310	4.40344319381e-09	0.823529411765	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 CXCL1 BIRC3 HTRA2 TBKBP1 TANK IRAK3 TRAF5	cellular response to organic substance
REAC:R-HSA-75893	6.57561167523e-09	0.352941176471	IKBKE TRAF2 TBK1 BIRC3 TRAF1 BIRC2	TNF signaling
REAC:R-HSA-166016	1.47271184301e-08	0.411764705882	TANK TRAF2 TBK1 BIRC3 BIRC2 IRAK3 IKBKE	Toll Like Receptor 4 (TLR4) Cascade
REAC:R-HSA-5357786	1.50817215377e-08	0.294117647059	TRAF2 TBK1 IKBKE BIRC3 BIRC2	TNFR1-induced proapoptotic signaling
GO:0035631	2.56367096242e-08	0.294117647059	BIRC2 HTRA2 TRAF2 DIABLO TRAF5	CD40 receptor complex
GO:0043122	2.75241623354e-08	0.529411764706	IKBKE TANK TRAF2 TBK1 BCL10 BIRC3 TRAF1 BIRC2 TRAF5	regulation of canonical NF-kappaB signal transduction
REAC:R-HSA-168898	4.07459363561e-08	0.411764705882	TANK TRAF2 TBK1 BIRC3 BIRC2 IRAK3 IKBKE	Toll-like Receptor Cascades
KEGG:04668	4.52949465683e-08	0.352941176471	TRAF5 TRAF2 CXCL1 BIRC3 TRAF1 BIRC2	TNF signaling pathway
WP:WP2036	4.67369677112e-08	0.294117647059	BIRC2 TRAF2 BIRC3 TRAF1 TRAF5	TNF related weak inducer of apoptosis TWEAK signaling pathway
GO:0007166	5.63074164608e-08	0.882352941176	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 IRAK3 CXCL1 BIRC3 HTRA2 TBKBP1 TANK DIABLO TRAF5	cell surface receptor signaling pathway
GO:0010033	1.20441030737e-07	0.823529411765	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 CXCL1 BIRC3 HTRA2 TBKBP1 TANK IRAK3 TRAF5	response to organic substance
GO:0035556	1.210609146e-07	0.882352941176	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 IRAK3 CXCL1 BIRC3 HTRA2 TBKBP1 TANK DIABLO TRAF5	intracellular signal transduction
REAC:R-HSA-168164	1.86280232547e-07	0.352941176471	TANK TRAF2 TBK1 BIRC3 BIRC2 IKBKE	Toll Like Receptor 3 (TLR3) Cascade
KEGG:04210	1.87306582582e-07	0.352941176471	TRAF2 TRAF1 BIRC3 HTRA2 BIRC2 DIABLO	Apoptosis
REAC:R-HSA-166166	2.12743769406e-07	0.352941176471	TANK TRAF2 TBK1 BIRC3 BIRC2 IKBKE	MyD88-independent TLR4 cascade
REAC:R-HSA-937061	2.12743769406e-07	0.352941176471	TANK TRAF2 TBK1 BIRC3 BIRC2 IKBKE	TRIF(TICAM1)-mediated TLR4 signaling
WP:WP5039	3.18686064527e-07	0.294117647059	TBK1 CXCL1 TANK TRAF5 TRAF2	SARS CoV 2 innate immunity evasion and cell specific immune response
GO:0070887	5.99052815016e-07	0.823529411765	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 CXCL1 BIRC3 HTRA2 TBKBP1 TANK IRAK3 TRAF5	cellular response to chemical stimulus
GO:0140546	6.86151899306e-07	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	defense response to symbiont
KEGG:04657	1.26400678098e-06	0.294117647059	CXCL1 TBK1 IKBKE TRAF5 TRAF2	IL-17 signaling pathway
REAC:R-HSA-73887	1.41130706306e-06	0.352941176471	IKBKE TRAF2 TBK1 BIRC3 TRAF1 BIRC2	Death Receptor Signaling
GO:0098542	1.56169536382e-06	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	defense response to other organism
KEGG:04215	1.76252435856e-06	0.235294117647	BIRC2 HTRA2 DIABLO BIRC3	Apoptosis - multiple species
WP:WP254	1.81545129353e-06	0.294117647059	BIRC2 TRAF2 DIABLO TRAF1 BIRC3	Apoptosis
KEGG:05222	2.21428576689e-06	0.294117647059	BIRC2 TRAF2 BIRC3 TRAF1 TRAF5	Small cell lung cancer
GO:0045087	4.10178376967e-06	0.588235294118	IKBKE BCL10 BIRC2 TRAF2 TBK1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	innate immune response
WP:WP4658	4.96205172477e-06	0.294117647059	BIRC2 TRAF2 BIRC3 TRAF1 TRAF5	Small cell lung cancer
REAC:R-HSA-933541	9.4266625371e-06	0.235294117647	TRAF2 IKBKE TANK TBK1	TRAF6 mediated IRF7 activation
GO:0051707	9.91749446436e-06	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	response to other organism
GO:0043207	9.91749446436e-06	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	response to external biotic stimulus
GO:0009607	1.40795773232e-05	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	response to biotic stimulus
REAC:R-HSA-5357956	1.42418816602e-05	0.235294117647	TRAF2 BIRC3 TRAF1 BIRC2	TNFR1-induced NF-kappa-B signaling pathway
GO:0042221	1.69844339769e-05	0.823529411765	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 CXCL1 BIRC3 HTRA2 TBKBP1 TANK IRAK3 TRAF5	response to chemical
GO:0043123	1.74343590216e-05	0.411764705882	TRAF5 TRAF2 TBK1 BIRC3 IKBKE BIRC2 BCL10	positive regulation of canonical NF-kappaB signal transduction
GO:0141124	1.86957688326e-05	0.705882352941	IKBKE TRAF5 BIRC2 TRAF2 TRAF1 TBK1 BIRC3 AZI2 TBKBP1 TANK IRAK3 BCL10	intracellular signaling cassette
GO:0044419	4.03052134711e-05	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	biological process involved in interspecies interaction between organisms
CORUM:5529	5.44233315652e-05	0.117647058824	TRAF2 BIRC2	TRAF2-cIAP1/BIRC2 complex
REAC:R-HSA-168249	5.46079659015e-05	0.529411764706	BCL10 TBK1 TRAF2 CXCL1 BIRC3 IKBKE BIRC2 IRAK3 TANK	Innate Immune System
REAC:R-HSA-5676594	6.91795163217e-05	0.176470588235	TRAF2 BIRC3 BIRC2	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
GO:0006952	7.29504953175e-05	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	defense response
GO:0006955	8.52655526954e-05	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	immune response
KEGG:05417	8.87331146362e-05	0.294117647059	CXCL1 TBK1 IKBKE TANK TRAF2	Lipid and atherosclerosis
REAC:R-HSA-9013973	9.21730694729e-05	0.176470588235	TBK1 TANK IKBKE	TICAM1-dependent activation of IRF3/IRF7
KEGG:05168	0.000142147191271	0.352941176471	IKBKE TRAF2 TBK1 BIRC3 BIRC2 TRAF5	Herpes simplex virus 1 infection
REAC:R-HSA-936964	0.000152285422166	0.176470588235	TBK1 TANK IKBKE	Activation of IRF3, IRF7 mediated by TBK1, IKBKE
CORUM:5210	0.000163158265417	0.117647058824	TRAF2 TANK	TANK-TRAF2-TRAF3 complex
CORUM:5531	0.000163158265417	0.117647058824	TRAF2 BIRC2	Tumor necrosis factor receptor 1 signaling complex
WP:WP1772	0.000192588874584	0.235294117647	BIRC2 HTRA2 DIABLO BIRC3	Apoptosis modulation and signaling
GO:0071356	0.000240394217525	0.352941176471	TANK TRAF2 BIRC3 TRAF1 BIRC2 TRAF5	cellular response to tumor necrosis factor
WP:WP3851	0.000336301914666	0.176470588235	TBK1 IRAK3 IKBKE	TLR4 signaling and tolerance
GO:0060337	0.000407992863512	0.294117647059	TBKBP1 TBK1 IKBKE TANK AZI2	type I interferon-mediated signaling pathway
GO:0009898	0.000410898144795	0.352941176471	TRAF5 TRAF2 TRAF1 HTRA2 BIRC2 DIABLO	cytoplasmic side of plasma membrane
GO:0071357	0.000441689044674	0.294117647059	TBKBP1 TBK1 IKBKE TANK AZI2	cellular response to type I interferon
GO:0034612	0.000466375816752	0.352941176471	TANK TRAF2 BIRC3 TRAF1 BIRC2 TRAF5	response to tumor necrosis factor
REAC:R-HSA-168928	0.000466841928372	0.235294117647	TRAF2 IKBKE TANK TBK1	DDX58/IFIH1-mediated induction of interferon-alpha/beta
WP:WP5406	0.000477978851782	0.176470588235	TRAF2 TRAF5 TRAF1	13q12 12 copy number variation
GO:1902531	0.000507399757389	0.647058823529	IKBKE TRAF5 TRAF2 TRAF1 TBK1 BIRC3 BIRC2 HTRA2 TANK IRAK3 BCL10	regulation of intracellular signal transduction
GO:0034340	0.000644979043176	0.294117647059	TBKBP1 TBK1 IKBKE TANK AZI2	response to type I interferon
GO:0033209	0.000744597320469	0.294117647059	BIRC2 TRAF2 BIRC3 TRAF1 TRAF5	tumor necrosis factor-mediated signaling pathway
KEGG:04217	0.000964875827058	0.235294117647	BIRC2 TRAF2 BIRC3 TRAF5	Necroptosis
GO:0051091	0.00130686056365	0.352941176471	IKBKE TRAF2 BCL10 TRAF1 IRAK3 TRAF5	positive regulation of DNA-binding transcription factor activity
GO:0098562	0.00140092265551	0.352941176471	TRAF5 TRAF2 TRAF1 HTRA2 BIRC2 DIABLO	cytoplasmic side of membrane
REAC:R-HSA-5213460	0.00167914157011	0.176470588235	TRAF2 BIRC3 BIRC2	RIPK1-mediated regulated necrosis
REAC:R-HSA-5675482	0.00167914157011	0.176470588235	TRAF2 BIRC3 BIRC2	Regulation of necroptotic cell death
GO:0140888	0.00173010736736	0.294117647059	TBKBP1 TBK1 IKBKE TANK AZI2	interferon-mediated signaling pathway
KEGG:05167	0.00215162555221	0.235294117647	CXCL1 TBK1 IKBKE TRAF2	Kaposi sarcoma-associated herpesvirus infection
WP:WP2018	0.00218633089518	0.176470588235	TRAF2 TRAF5 TRAF1	RANKL RANK signaling pathway
GO:0065009	0.00244461826832	0.647058823529	IKBKE TRAF5 TRAF2 TRAF1 DIABLO BIRC3 BIRC2 HTRA2 TANK IRAK3 BCL10	regulation of molecular function
GO:0052547	0.00269035767626	0.352941176471	TANK BIRC3 HTRA2 BIRC2 DIABLO BCL10	regulation of peptidase activity
GO:0007165	0.00280203861615	0.882352941176	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 IRAK3 CXCL1 BIRC3 HTRA2 TBKBP1 TANK DIABLO TRAF5	signal transduction
KEGG:05169	0.00281799366529	0.235294117647	TRAF2 IKBKE TRAF5 TBK1	Epstein-Barr virus infection
GO:0051092	0.0039303078488	0.294117647059	TRAF2 TRAF5 BCL10 TRAF1 IRAK3	positive regulation of NF-kappaB transcription factor activity
WP:WP5116	0.00403545676893	0.117647058824	TBK1 IKBKE	SARS CoV 2 B 1 1 7 variant antagonises innate immune activation
GO:0009605	0.00412992633924	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	response to external stimulus
GO:0002376	0.00477806604769	0.647058823529	IKBKE BCL10 TBK1 BIRC2 TRAF2 CXCL1 BIRC3 AZI2 TBKBP1 IRAK3 TANK	immune system process
CORUM:6344	0.00491201406937	0.117647058824	TRAF2 BIRC3	TNF-R1-associated signaling complex
GO:0031996	0.00546674693619	0.176470588235	TRAF2 TRAF5 TRAF1	thioesterase binding
GO:0044093	0.00636417630624	0.529411764706	IKBKE TRAF5 TRAF2 DIABLO TRAF1 HTRA2 TANK IRAK3 BCL10	positive regulation of molecular function
KEGG:05131	0.00694024346742	0.235294117647	TRAF2 TBK1 BCL10 TRAF5	Shigellosis
KEGG:05200	0.00712716583752	0.294117647059	BIRC2 TRAF2 BIRC3 TRAF1 TRAF5	Pathways in cancer
HP:0012123	0.00829411048776	0.117647058824	BCL10 BIRC3	Posterior uveitis
GO:0023052	0.00877380510656	0.882352941176	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 IRAK3 CXCL1 BIRC3 HTRA2 TBKBP1 TANK DIABLO TRAF5	signaling
REAC:R-HSA-5218859	0.00952965661128	0.176470588235	TRAF2 BIRC3 BIRC2	Regulated Necrosis
GO:0002224	0.00991804849301	0.235294117647	IRAK3 BIRC2 BCL10 BIRC3	toll-like receptor signaling pathway
GO:0007154	0.0104660452271	0.882352941176	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 IRAK3 CXCL1 BIRC3 HTRA2 TBKBP1 TANK DIABLO TRAF5	cell communication
REAC:R-HSA-168256	0.0117345503728	0.529411764706	BCL10 TBK1 TRAF2 CXCL1 BIRC3 IKBKE BIRC2 IRAK3 TANK	Immune System
GO:0045089	0.011890935677	0.352941176471	IKBKE TBK1 BIRC3 BIRC2 IRAK3 BCL10	positive regulation of innate immune response
GO:0031625	0.0121765865222	0.352941176471	TANK TRAF2 TRAF5 BCL10 TRAF1 IKBKE	ubiquitin protein ligase binding
GO:1902554	0.012523500217	0.294117647059	TBKBP1 TBK1 IKBKE TANK AZI2	serine/threonine protein kinase complex
WP:WP5182	0.0130614919572	0.117647058824	TRAF2 BIRC3	Pro survival signaling of neuroprotectin D1
REAC:R-HSA-1280215	0.0137530670783	0.352941176471	TBK1 TRAF2 CXCL1 BIRC3 BIRC2 IRAK3	Cytokine Signaling in Immune system
GO:0098802	0.0140846537912	0.294117647059	BIRC2 HTRA2 TRAF2 DIABLO TRAF5	plasma membrane signaling receptor complex
GO:0044389	0.01718725057	0.352941176471	TANK TRAF2 TRAF5 BCL10 TRAF1 IKBKE	ubiquitin-like protein ligase binding
GO:0002833	0.0183687777507	0.352941176471	IKBKE TBK1 BIRC3 BIRC2 IRAK3 BCL10	positive regulation of response to biotic stimulus
GO:2000116	0.0190117104724	0.294117647059	BIRC2 HTRA2 BIRC3 DIABLO BCL10	regulation of cysteine-type endopeptidase activity
GO:0070534	0.0191117710917	0.235294117647	TRAF2 TRAF5 TRAF1 BIRC2	protein K63-linked ubiquitination
REAC:R-HSA-5357801	0.0201830696937	0.235294117647	BIRC2 TRAF2 DIABLO BIRC3	Programmed Cell Death
WP:WP4961	0.0219005077051	0.117647058824	TBK1 IKBKE	STING pathway in Kawasaki like disease and COVID 19
GO:0051090	0.0223212796651	0.352941176471	IKBKE TRAF2 BCL10 TRAF1 IRAK3 TRAF5	regulation of DNA-binding transcription factor activity
KEGG:04936	0.0224137504747	0.176470588235	CXCL1 IKBKE TBK1	Alcoholic liver disease
GO:0097191	0.0227251270156	0.294117647059	HTRA2 TRAF2 DIABLO TRAF1 BCL10	extrinsic apoptotic signaling pathway
GO:1902911	0.0235322970534	0.294117647059	TBKBP1 TBK1 IKBKE TANK AZI2	protein kinase complex
GO:0009615	0.023784566561	0.352941176471	TANK AZI2 TBK1 TBKBP1 IRAK3 IKBKE	response to virus
WP:WP2507	0.0244602970875	0.117647058824	HTRA2 DIABLO	Nanomaterial induced apoptosis
KEGG:05160	0.026329664903	0.176470588235	TRAF2 IKBKE TBK1	Hepatitis C
WP:000000	0.0277689049221	0.882352941176	IKBKE TBK1 BCL10 AZI2 BIRC2 TRAF2 TRAF1 IRAK3 CXCL1 BIRC3 HTRA2 TBKBP1 TANK DIABLO TRAF5	WIKIPATHWAYS
GO:0034121	0.0294840968368	0.176470588235	BIRC2 BIRC3 IRAK3	regulation of toll-like receptor signaling pathway
GO:0050778	0.0309213710656	0.411764705882	BCL10 TRAF2 TBK1 BIRC3 BIRC2 IRAK3 IKBKE	positive regulation of immune response
WP:WP4868	0.0360908991413	0.117647058824	TBK1 IKBKE	Type I interferon induction and signaling during SARS CoV 2 infection
REAC:R-HSA-918233	0.0370777836204	0.117647058824	TBK1 IKBKE	TRAF3-dependent IRF activation pathway
REAC:R-HSA-5668541	0.040655371765	0.176470588235	TRAF2 BIRC3 BIRC2	TNFR2 non-canonical NF-kB pathway
GO:0045088	0.0416582814018	0.352941176471	IKBKE TBK1 BIRC3 BIRC2 IRAK3 BCL10	regulation of innate immune response
KEGG:05202	0.0430215657016	0.176470588235	BIRC2 BIRC3 TRAF1	Transcriptional misregulation in cancer
WP:WP4950	0.0462667850985	0.117647058824	TRAF2 TRAF1	16p11 2 distal deletion syndrome
CORUM:2052	0.0497089104684	0.0588235294118	BCL10	BCL10 homo-oligomer complex
WP:WP3858	0.0499339620047	0.117647058824	TBK1 IKBKE	Toll like receptor signaling related to MyD88

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
TRAF2	TRAF1	1.0	0.088	structurally_consistent (dimer)
BIRC2	DIABLO	1.0	0.128
BIRC2	TRAF1	0.999	0.166	structurally_consistent (dimer)
TANK	TRAF1	0.999	0.136
TANK	TRAF2	0.999	0.148952380952
BIRC2	TRAF2	0.999	0.2272	mutually_exclusive (Q13077)
AZI2	BBOX1	0.999
TRAF1	TBK1	0.999	0.124
TANK	TBK1	0.998	0.194
BIRC2	HTRA2	0.998	0.124
TRAF2	TBK1	0.998	0.06
CXCL3	CXCL2	0.998		mutually_exclusive (P09341) structurally_consistent (dimer)
BBOX1	TBK1	0.997
BBOX1	TANK	0.997
TRAF2	DIABLO	0.996	0.074	structurally_consistent (dimer)
BIRC3	BCL10	0.996
BIRC2	CXCL1	0.995
HTRA2	TRAF2	0.994	0.034
TANK	DIABLO	0.993	0.128
AZI2	TBK1	0.99	0.12
CXCL1	TRAF2	0.987
TRAF1	DIABLO	0.986	0.168
CXCL1	TBK1	0.984
TANK	IKBKE	0.98
HTRA2	TRAF1	0.98	0.092
TRAF2	IKBKE	0.976
HTRA2	DIABLO	0.973	0.374
CXCL3	CXCL1	0.972		mutually_exclusive (P19875) structurally_consistent (dimer)
BIRC3	TRAF2	0.969		mutually_exclusive (Q9NR28)
BIRC3	TRAF1	0.966
BIRC3	DIABLO	0.964		structurally_consistent (dimer)
BIRC2	TANK	0.955	0.172
HTRA2	TANK	0.952	0.096
CXCL1	DIABLO	0.952
BIRC2	TBK1	0.939	0.184
CXCL3	TRAF2	0.928
AZI2	IRAK3	0.921	0.132
BCL10	TRAF2	0.917	0.048
CXCL1	CXCL2	0.894		mutually_exclusive (P19876) structurally_consistent (dimer)
BIRC3	IKBKE	0.892
TRAF5	TANK	0.886	0.14
AZI2	TANK	0.874	0.162
BIRC2	SYCN	0.862
TBK1	DIABLO	0.858	0.052
TBK1	TBKBP1	0.85
BIRC2	CXCL3	0.797
TRAF1	IKBKE	0.796
BIRC2	IKBKE	0.492
TBK1	IRAK3	0.483	0.114
IKBKE	TBK1	0.456		structurally_consistent (dimer)
HTRA2	IKBKE	0.451
BIRC2	BIRC3	0.438
BIRC3	TANK	0.384
IKBKE	DIABLO	0.374
BIRC3	TBK1	0.373
AZI2	TBKBP1	0.371
TRAF2	CXCL2	0.334
BIRC3	HTRA2	0.306
HTRA2	TBK1	0.277	0.042
BIRC2	BCL10	0.228	0.082
SYCN	TRAF2	0.186
TRAF5	TBKBP1	0.138
TRAF5	IKBKE	0.113
BIRC2	CXCL2	0.105
TRAF5	TRAF1	0.076	0.148
BIRC2	TRAF5	0.064	0.152
TRAF5	HTRA2	0.053	0.06
AZI2	HTRA2	0.052	0.09
TRAF5	TRAF2	0.051	0.126
CXCL1	TANK	0.043
TRAF2	TBKBP1	0.022
HTRA2	TBKBP1	0.022
AZI2	DIABLO	0.022	0.102
SYCN	HTRA2	0.02
TRAF5	TBK1	0.02	0.13
TRAF5	DIABLO	0.016	0.136
DIABLO	TBKBP1	0.015
AZI2	TRAF2	0.014	0.158
AZI2	TRAF5	0.014	0.094
BCL10	TBK1	0.008	0.058	structurally_consistent (Q14164)

Related Complexes

Genename	Complexes
CXCL1	huMAP3_02215.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12588.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13249.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
DIABLO	huMAP3_05765.1 huMAP3_06254.1 huMAP3_07387.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
HTRA2	huMAP3_02517.1 huMAP3_03100.1 huMAP3_03925.1 huMAP3_05775.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_08787.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09818.1 huMAP3_09978.1 huMAP3_10711.1 huMAP3_12700.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1
BCL10	huMAP3_01302.1 huMAP3_02031.1 huMAP3_02285.1 huMAP3_05158.1 huMAP3_05694.1 huMAP3_05700.1 huMAP3_06364.1 huMAP3_07071.1 huMAP3_08125.1 huMAP3_11795.1 huMAP3_12680.1 huMAP3_13879.1
BIRC3	huMAP3_01302.1 huMAP3_02031.1 huMAP3_02285.1 huMAP3_02517.1 huMAP3_03925.1 huMAP3_05158.1 huMAP3_05694.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_08312.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
TBKBP1	huMAP3_11248.1 huMAP3_11496.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_14821.1 huMAP3_15146.1 huMAP3_15257.1
IRAK3	huMAP3_11252.1 huMAP3_12343.1 huMAP3_12986.1 huMAP3_13723.1 huMAP3_13879.1 huMAP3_13917.1 huMAP3_15146.1
TRAF5	huMAP3_00937.1 huMAP3_02595.1 huMAP3_05172.1 huMAP3_07571.1 huMAP3_08385.1 huMAP3_08640.1 huMAP3_10605.1 huMAP3_10687.1 huMAP3_11771.1 huMAP3_12053.1 huMAP3_12088.1 huMAP3_12986.1 huMAP3_13843.1 huMAP3_13879.1 huMAP3_14423.1 huMAP3_15146.1
TRAF2	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
BBOX1	huMAP3_02194.1 huMAP3_07956.1 huMAP3_08217.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1
AZI2	huMAP3_00422.1 huMAP3_04363.1 huMAP3_08217.1 huMAP3_08972.1 huMAP3_10832.1 huMAP3_12343.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13723.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
BIRC2	huMAP3_00079.1 huMAP3_05765.1 huMAP3_07387.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
CXCL2	huMAP3_04193.1 huMAP3_11292.1 huMAP3_12588.1 huMAP3_12680.1 huMAP3_13249.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
CXCL3	huMAP3_02215.1 huMAP3_04193.1 huMAP3_06150.1 huMAP3_09978.1 huMAP3_11292.1 huMAP3_12588.1 huMAP3_12680.1 huMAP3_13249.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
SYCN	huMAP3_00477.1 huMAP3_11779.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1
TANK	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
TBK1	huMAP3_03925.1 huMAP3_06254.1 huMAP3_09536.1 huMAP3_10832.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1
TRAF1	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_14463.1 huMAP3_15146.1 huMAP3_15257.1
IKBKE	huMAP3_02517.1 huMAP3_03925.1 huMAP3_06254.1 huMAP3_06826.1 huMAP3_08034.1 huMAP3_09205.1 huMAP3_09536.1 huMAP3_09978.1 huMAP3_12680.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1 huMAP3_15257.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13879.1

Complex Portal: CPX-24878