hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13904.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACTR3B | Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4) | 4 | UniProt NCBI |
| ARPC1B | Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC) | 5 | UniProt NCBI |
| ARPC2 | Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) | 5 | UniProt NCBI |
| RALA | Ras-related protein Ral-A (EC 3.6.5.2) | 5 | UniProt NCBI |
| ACTR2 | Actin-related protein 2 (Actin-like protein 2) | 5 | UniProt NCBI |
| CHURC1 | Protein Churchill | 4 | UniProt NCBI |
| ARPC1A | Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) | 4 | UniProt NCBI |
| ARPC5 | Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) | 5 | UniProt NCBI |
| ABCG2 | Broad substrate specificity ATP-binding cassette transporter ABCG2 (EC 7.6.2.2) (ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) | 5 | UniProt NCBI |
| ACTR3 | Actin-related protein 3 (Actin-like protein 3) | 5 | UniProt NCBI |
| ARPC4 | Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) | 5 | UniProt NCBI |
| ARPC3 | Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:27 | 7.76518645207e-22 | 0.636363636364 | ARPC1B ACTR3 ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Arp2/3 protein complex |
| GO:0005885 | 1.44071909585e-21 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Arp2/3 protein complex |
| KEGG:05100 | 4.73616940399e-18 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-5663213 | 1.49906583654e-17 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | RHO GTPases Activate WASPs and WAVEs |
| KEGG:04666 | 2.34380369895e-17 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | Fc gamma R-mediated phagocytosis |
| REAC:R-HSA-3928662 | 4.03476120564e-17 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | EPHB-mediated forward signaling |
| KEGG:05135 | 2.32649055627e-16 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | Yersinia infection |
| REAC:R-HSA-9664407 | 7.29252352972e-16 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Parasite infection |
| REAC:R-HSA-9664417 | 7.29252352972e-16 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Leishmania phagocytosis |
| REAC:R-HSA-9664422 | 7.29252352972e-16 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-2029482 | 1.16811838715e-15 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Regulation of actin dynamics for phagocytic cup formation |
| KEGG:04530 | 1.35159749361e-15 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | Tight junction |
| KEGG:05130 | 6.57786379691e-15 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | Pathogenic Escherichia coli infection |
| GO:0034314 | 1.22413467301e-14 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Arp2/3 complex-mediated actin nucleation |
| REAC:R-HSA-2029480 | 1.92035716207e-14 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-2682334 | 2.91698377298e-14 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | EPH-Ephrin signaling |
| KEGG:04810 | 3.05123208191e-14 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | Regulation of actin cytoskeleton |
| GO:0045010 | 3.42794308522e-14 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | actin nucleation |
| KEGG:05132 | 1.08516470732e-13 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | Salmonella infection |
| KEGG:05131 | 1.22540537132e-13 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | Shigellosis |
| KEGG:04144 | 1.43734452201e-13 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | Endocytosis |
| REAC:R-HSA-9658195 | 1.90703124732e-12 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Leishmania infection |
| REAC:R-HSA-9824443 | 1.90703124732e-12 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Parasitic Infection Pathways |
| GO:0051015 | 8.04422868981e-12 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | actin filament binding |
| WP:WP2272 | 4.92495326337e-11 | 0.545454545455 | ARPC1B ARPC3 ARPC1A ARPC4 ARPC2 ARPC5 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-8856828 | 3.85690970948e-10 | 0.636363636364 | ARPC2 ARPC1A ARPC3 ARPC4 ACTR3 ACTR2 ARPC5 | Clathrin-mediated endocytosis |
| GO:0003779 | 7.14083627998e-10 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | actin binding |
| REAC:R-HSA-195258 | 1.04521536739e-09 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | RHO GTPase Effectors |
| GO:0035861 | 1.25730329339e-09 | 0.636363636364 | ARPC2 ARPC1A ARPC3 ARPC4 ACTR3 ACTR2 ARPC5 | site of double-strand break |
| GO:0005200 | 4.28242331955e-09 | 0.636363636364 | ARPC1B ACTR3 ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | structural constituent of cytoskeleton |
| GO:0090734 | 1.05542926856e-08 | 0.636363636364 | ARPC2 ARPC1A ARPC3 ARPC4 ACTR3 ACTR2 ARPC5 | site of DNA damage |
| REAC:R-HSA-422475 | 5.17883585274e-08 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Axon guidance |
| REAC:R-HSA-9675108 | 6.93528278935e-08 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Nervous system development |
| REAC:R-HSA-194315 | 4.34943461634e-07 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 5.17684587533e-07 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0007015 | 5.71789218263e-07 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | actin filament organization |
| GO:0015629 | 1.37511233778e-06 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | actin cytoskeleton |
| GO:0008092 | 3.61480138266e-06 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | cytoskeletal protein binding |
| REAC:R-HSA-1266738 | 4.80729188049e-06 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Developmental Biology |
| REAC:R-HSA-5663205 | 5.2683939111e-06 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Infectious disease |
| REAC:R-HSA-168249 | 6.53504346773e-06 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Innate Immune System |
| REAC:R-HSA-199991 | 1.02374892594e-05 | 0.636363636364 | ARPC2 ARPC1A ARPC3 ARPC4 ACTR3 ACTR2 ARPC5 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 1.48868457168e-05 | 0.636363636364 | ARPC2 ARPC1A ARPC3 ARPC4 ACTR3 ACTR2 ARPC5 | Vesicle-mediated transport |
| GO:0030036 | 2.16031537938e-05 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | actin cytoskeleton organization |
| GO:0030029 | 5.1252476381e-05 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | actin filament-based process |
| GO:0097435 | 6.08921263074e-05 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | supramolecular fiber organization |
| GO:0044877 | 0.000281816838842 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | protein-containing complex binding |
| GO:0070358 | 0.000316805542726 | 0.272727272727 | ARPC2 ARPC3 ACTR3 | actin polymerization-dependent cell motility |
| REAC:R-HSA-1643685 | 0.000360075861783 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Disease |
| GO:0005198 | 0.000872055876843 | 0.636363636364 | ARPC1B ACTR3 ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | structural molecule activity |
| REAC:R-HSA-168256 | 0.000961215599937 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Immune System |
| REAC:R-HSA-162582 | 0.00386179598205 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | Signal Transduction |
| GO:0005925 | 0.00403667931718 | 0.545454545455 | ARPC1B ACTR3 ARPC3 ACTR2 ARPC5 ARPC2 | focal adhesion |
| GO:0030055 | 0.00453418606293 | 0.545454545455 | ARPC1B ACTR3 ARPC3 ACTR2 ARPC5 ARPC2 | cell-substrate junction |
| GO:0007010 | 0.00684866398324 | 0.727272727273 | ARPC1B ACTR3 ARPC1A ARPC3 ARPC4 ARPC2 ACTR2 ARPC5 | cytoskeleton organization |
| GO:0070062 | 0.0161989154061 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | extracellular exosome |
| GO:1903561 | 0.0175656105693 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | extracellular vesicle |
| GO:0043230 | 0.0176490795663 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | extracellular organelle |
| GO:0065010 | 0.0176490795663 | 0.818181818182 | ARPC1B ARPC2 ARPC1A ARPC3 ACTR3B ACTR3 ACTR2 ARPC5 ARPC4 | extracellular membrane-bounded organelle |
| GO:0010592 | 0.0278578876014 | 0.272727272727 | ARPC2 ACTR3 ACTR2 | positive regulation of lamellipodium assembly |
| HPA:0310433 | 0.0339626283727 | 0.454545454545 | ARPC1B ARPC3 ACTR3 ACTR2 ARPC2 | lymph node; germinal center cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| ACTR3 | ARPC4 | 1.0 | 0.962 |
| ACTR2 | ACTR3 | 1.0 | 0.938 |
| ARPC1B | ACTR3 | 1.0 | 0.924 |
| ACTR2 | ARPC1B | 1.0 | 0.874 |
| ARPC1A | ARPC3 | 1.0 | 0.324 |
| ACTR2 | ARPC5 | 1.0 | 0.866 |
| ACTR3 | ARPC3 | 1.0 | 0.956 |
| ACTR2 | ARPC4 | 1.0 | 0.932 |
| ACTR2 | ARPC1A | 1.0 | 0.524 |
| ARPC1A | ARPC4 | 1.0 | 0.346 |
| ARPC1B | ARPC4 | 1.0 | 0.854 |
| ARPC1A | ARPC5 | 1.0 | 0.184 |
| ARPC5 | ACTR3 | 1.0 | 0.894 |
| ACTR2 | ARPC3 | 1.0 | 0.942 |
| ACTR3B | ARPC4 | 1.0 | 0.902 |
| ACTR2 | ARPC2 | 1.0 | 0.99 |
| ARPC2 | ARPC4 | 1.0 | 0.978 |
| ARPC2 | ACTR3 | 1.0 | 0.966 |
| ACTR3B | ARPC3 | 1.0 | 0.81 |
| ARPC1A | ACTR3 | 1.0 | 0.476 |
| ARPC2 | ARPC5 | 1.0 | 0.934 |
| ARPC1B | ARPC2 | 0.999 | 0.936 |
| ARPC2 | ARPC3 | 0.999 | 0.982 |
| ARPC1B | ARPC3 | 0.999 | 0.846 |
| ACTR3B | ARPC1A | 0.999 | 0.184714893617 |
| ARPC5 | ARPC4 | 0.999 | 0.786 |
| ACTR3B | ARPC1B | 0.999 | 0.522 |
| ARPC1A | ARPC2 | 0.999 | 0.456 |
| ARPC5 | ARPC3 | 0.999 | 0.936 |
| ACTR3B | ARPC5 | 0.999 | 0.458 |
| ARPC4 | ARPC3 | 0.999 | 0.946 |
| ACTR3B | ACTR2 | 0.999 | 0.884 |
| CHURC1 | ARPC3 | 0.999 | 0.092 |
| ACTR3B | ARPC2 | 0.999 | 0.866 |
| ARPC1B | ARPC5 | 0.999 | 0.806 |
| ACTR3B | CHURC1 | 0.998 | 0.158 |
| CHURC1 | ACTR2 | 0.997 | 0.114 |
| CHURC1 | ACTR3 | 0.993 | 0.094 |
| ACTR3B | ACTR3 | 0.992 | 0.826 |
| ARPC1A | ARPC1B | 0.987 | 0.212 |
| CHURC1 | ARPC4 | 0.968 | 0.064 |
| CHURC1 | ARPC2 | 0.962 | 0.08 |
| RALA | ARPC5 | 0.894 | 0.04 |
| ABCG2 | ACTR2 | 0.894 | 0.084 |
| RALA | ARPC2 | 0.862 | 0.086 |
| RALA | ARPC3 | 0.861 | 0.152 |
| ABCG2 | ARPC1B | 0.861 | 0.062 |
| ABCG2 | ARPC2 | 0.86 | 0.072 |
| RALA | ACTR2 | 0.852 | 0.048 |
| CHURC1 | ARPC5 | 0.85 | 0.074 |
| RALA | ARPC1B | 0.823 | 0.104 |
| ABCG2 | ARPC3 | 0.814 | 0.082 |
| ABCG2 | ARPC5 | 0.803 | 0.118 |
| RALA | ARPC4 | 0.801 | 0.132 |
| CHURC1 | ARPC1A | 0.772 | 0.082 |
| RALA | ACTR3 | 0.737 | 0.058 |
| ABCG2 | ACTR3 | 0.435 | 0.084 |
| CHURC1 | ARPC1B | 0.42 | 0.068 |
| ABCG2 | ARPC1A | 0.243 | 0.048 |
| RALA | ABCG2 | 0.121 | 0.078 |
| ABCG2 | ARPC4 | 0.059 | 0.0925714285714 |
| RALA | ARPC1A | 0.027 | 0.126 |
| RALA | CHURC1 | 0.022 | 0.12 |
| RALA | ACTR3B | 0.021 | 0.114714893617 |
| ABCG2 | ACTR3B | 0.018 | 0.128 |
Related Complexes