hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13906.1
Confidence: Medium  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
MAFK | Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit) | 5 | UniProt   NCBI |
MAFF | Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) | 5 | UniProt   NCBI |
CALCOCO1 | Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3) | 5 | UniProt   NCBI |
NFE2L3 | Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3) | 5 | UniProt   NCBI |
BACH1 | Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) | 5 | UniProt   NCBI |
CYP4V2 | Cytochrome P450 4V2 (Docosahexaenoic acid omega-hydroxylase CYP4V2) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) | 5 | UniProt   NCBI |
NFE2L1 | Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)] | 5 | UniProt   NCBI |
HMMR | Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) | 5 | UniProt   NCBI |
MAFG | Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (hMAF) | 5 | UniProt   NCBI |
BACH2 | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | 5 | UniProt   NCBI |
NFE2L2 | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2) | 5 | UniProt   NCBI |
KRT18 | Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18) | 5 | UniProt   NCBI |
RTL6 | Retrotransposon Gag-like protein 6 (Leucine zipper protein down-regulated in cancer cells-like) (Mammalian retrotransposon-derived protein 6) (Protein LDOC1L) | 3 | UniProt   NCBI |
FBXO22 | F-box only protein 22 (F-box protein FBX22p44) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  WP:WP4269 | 4.28832438719e-09 | 0.285714285714 | MAFK NFE2L2 MAFF MAFG | Ethanol metabolism production of ROS by CYP2E1 |
  REAC:R-HSA-9707587 | 1.96338187373e-06 | 0.214285714286 | MAFK NFE2L2 BACH1 | Regulation of HMOX1 expression and activity |
  GO:0090575 | 1.52266394179e-05 | 0.5 | NFE2L2 BACH2 MAFK NFE2L3 MAFG BACH1 MAFF | RNA polymerase II transcription regulator complex |
  WP:WP2435 | 2.95026604181e-05 | 0.214285714286 | MAFK NFE2L2 MAFG | Quercetin and Nf kB AP 1 induced apoptosis |
  REAC:R-HSA-9818027 | 0.000109268371341 | 0.214285714286 | MAFK NFE2L2 BACH1 | NFE2L2 regulating anti-oxidant/detoxification enzymes |
  REAC:R-HSA-9759194 | 0.000202676802324 | 0.285714285714 | MAFK NFE2L2 MAFG BACH1 | Nuclear events mediated by NFE2L2 |
  GO:0000978 | 0.000219917597735 | 0.642857142857 | NFE2L1 MAFF NFE2L2 MAFK CALCOCO1 NFE2L3 MAFG BACH1 BACH2 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
  GO:0000987 | 0.000263907699919 | 0.642857142857 | NFE2L1 MAFF NFE2L2 MAFK CALCOCO1 NFE2L3 MAFG BACH1 BACH2 | cis-regulatory region sequence-specific DNA binding |
  REAC:R-HSA-9755511 | 0.000644070617096 | 0.285714285714 | MAFK NFE2L2 MAFG BACH1 | KEAP1-NFE2L2 pathway |
  GO:0005667 | 0.000753224270847 | 0.5 | NFE2L2 BACH2 MAFK NFE2L3 MAFG BACH1 MAFF | transcription regulator complex |
  GO:0000977 | 0.000916990234428 | 0.642857142857 | NFE2L1 MAFF NFE2L2 MAFK CALCOCO1 NFE2L3 MAFG BACH1 BACH2 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
  GO:0000976 | 0.00193052332818 | 0.642857142857 | NFE2L1 MAFF NFE2L2 MAFK CALCOCO1 NFE2L3 MAFG BACH1 BACH2 | transcription cis-regulatory region binding |
  GO:0001067 | 0.0019477802701 | 0.642857142857 | NFE2L1 MAFF NFE2L2 MAFK CALCOCO1 NFE2L3 MAFG BACH1 BACH2 | transcription regulatory region nucleic acid binding |
  REAC:R-HSA-9707616 | 0.00220733602789 | 0.214285714286 | MAFK NFE2L2 BACH1 | Heme signaling |
  GO:1990837 | 0.00290410408744 | 0.642857142857 | NFE2L1 MAFF NFE2L2 MAFK CALCOCO1 NFE2L3 MAFG BACH1 BACH2 | sequence-specific double-stranded DNA binding |
  GO:0043565 | 0.00540172587396 | 0.642857142857 | NFE2L1 MAFF NFE2L2 MAFK CALCOCO1 NFE2L3 MAFG BACH1 BACH2 | sequence-specific DNA binding |
  GO:0003690 | 0.0055305495206 | 0.642857142857 | NFE2L1 MAFF NFE2L2 MAFK CALCOCO1 NFE2L3 MAFG BACH1 BACH2 | double-stranded DNA binding |
  REAC:R-HSA-9711123 | 0.00606366923092 | 0.285714285714 | MAFK NFE2L2 MAFG BACH1 | Cellular response to chemical stress |
  REAC:R-HSA-9707564 | 0.00619094878017 | 0.214285714286 | MAFK NFE2L2 BACH1 | Cytoprotection by HMOX1 |
  REAC:R-HSA-9818028 | 0.00668012550606 | 0.142857142857 | MAFG NFE2L2 | NFE2L2 regulates pentose phosphate pathway genes |
  REAC:R-HSA-9708530 | 0.0131001388031 | 0.142857142857 | MAFK BACH1 | Regulation of BACH1 activity |
  GO:0000981 | 0.0172292094179 | 0.571428571429 | NFE2L1 MAFF NFE2L2 MAFK NFE2L3 MAFG BACH1 BACH2 | DNA-binding transcription factor activity, RNA polymerase II-specific |
  WP:WP2884 | 0.0174775848213 | 0.214285714286 | MAFG MAFF NFE2L2 | NRF2 pathway |
  GO:0003700 | 0.0277666812551 | 0.571428571429 | NFE2L1 MAFF NFE2L2 MAFK NFE2L3 MAFG BACH1 BACH2 | DNA-binding transcription factor activity |
  GO:0140110 | 0.0295551162235 | 0.642857142857 | NFE2L1 MAFF NFE2L2 MAFK CALCOCO1 NFE2L3 MAFG BACH1 BACH2 | transcription regulator activity |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD |
---|---|---|---|
 HMMR |  BACH1 | 1.0 | 0.116           |
 BACH1 |  MAFK | 1.0 | 0.114           |
 MAFF |  NFE2L2 | 0.999 |            |
 BACH1 |  MAFG | 0.999 | 0.062           |
 MAFF |  BACH2 | 0.999 |            |
 BACH1 |  MAFF | 0.999 | 0.068           |
 NFE2L3 |  MAFF | 0.998 |            |
 MAFF |  NFE2L1 | 0.998 |            |
 RTL6 |  MAFF | 0.997 |            |
 FBXO22 |  BACH1 | 0.995 | 0.034           |
 CALCOCO1 |  MAFF | 0.994 | 0.062           |
 NFE2L3 |  MAFK | 0.994 |            |
 NFE2L3 |  MAFG | 0.991 |            |
 BACH1 |  BACH2 | 0.988 |            |
 MAFK |  MAFF | 0.985 | 0.206           |
 CALCOCO1 |  BACH2 | 0.975 |            |
 MAFK |  MAFG | 0.974 | 0.248           |
 MAFK |  BACH2 | 0.972 |            |
 FBXO22 |  CYP4V2 | 0.96 |            |
 MAFF |  MAFG | 0.956 | 0.208           |
 MAFK |  NFE2L2 | 0.955 |            |
 NFE2L3 |  NFE2L2 | 0.947 |            |
 NFE2L1 |  NFE2L2 | 0.939 |            |
 CALCOCO1 |  NFE2L1 | 0.918 |            |
 MAFG |  BACH2 | 0.913 |            |
 BACH2 |  NFE2L2 | 0.908 |            |
 NFE2L3 |  NFE2L1 | 0.908 |            |
 NFE2L1 |  BACH2 | 0.904 |            |
 HMMR |  KRT18 | 0.901 | 0.142           |
 BACH1 |  NFE2L2 | 0.888 |            |
 CALCOCO1 |  NFE2L2 | 0.888 |            |
 NFE2L3 |  BACH1 | 0.885 |            |
 NFE2L3 |  BACH2 | 0.884 |            |
 BACH1 |  NFE2L1 | 0.884 |            |
 HMMR |  MAFF | 0.864 | 0.03           |
 NFE2L3 |  CALCOCO1 | 0.862 |            |
 FBXO22 |  MAFF | 0.855 | 0.066           |
 FBXO22 |  MAFK | 0.842 | 0.052           |
 RTL6 |  BACH1 | 0.84 |            |
 HMMR |  MAFG | 0.833 | 0.108           |
 FBXO22 |  MAFG | 0.828 | 0.036           |
 HMMR |  MAFK | 0.796 | 0.076           |
 MAFK |  NFE2L1 | 0.772 |            |
 CALCOCO1 |  BACH1 | 0.696 | 0.092           |
 FBXO22 |  HMMR | 0.4 | 0.042           |
 RTL6 |  NFE2L2 | 0.378 |            |
 RTL6 |  BACH2 | 0.32 |            |
 NFE2L3 |  RTL6 | 0.224 |            |
 RTL6 |  NFE2L1 | 0.215 |            |
 MAFG |  NFE2L2 | 0.21 |            |
 FBXO22 |  NFE2L3 | 0.173 |            |
 CALCOCO1 |  MAFK | 0.159 | 0.09           |
 CALCOCO1 |  RTL6 | 0.152 |            |
 HMMR |  NFE2L1 | 0.102 |            |
 FBXO22 |  NFE2L1 | 0.092 |            |
 FBXO22 |  NFE2L2 | 0.091 |            |
 CALCOCO1 |  MAFG | 0.089 | 0.126           |
 NFE2L1 |  MAFG | 0.076 |            |
 HMMR |  CALCOCO1 | 0.046 | 0.114           |
 FBXO22 |  BACH2 | 0.045 |            |
 FBXO22 |  RTL6 | 0.026 |            |
 FBXO22 |  CALCOCO1 | 0.013 | 0.024           |
 CALCOCO1 |  KRT18 | 0.003 | 0.204           |
 BACH2 |  KRT18 | 0.002 |            |
Related Complexes