hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13906.1

Complex Portal: CPX-20264

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
MAFK	Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit)	5	UniProt NCBI
MAFF	Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F)	5	UniProt NCBI
CALCOCO1	Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3)	5	UniProt NCBI
NFE2L3	Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3)	5	UniProt NCBI
BACH1	Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303)	5	UniProt NCBI
CYP4V2	Cytochrome P450 4V2 (Docosahexaenoic acid omega-hydroxylase CYP4V2) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80)	5	UniProt NCBI
NFE2L1	Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]	5	UniProt NCBI
HMMR	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)	5	UniProt NCBI
MAFG	Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (hMAF)	5	UniProt NCBI
BACH2	Transcription regulator protein BACH2 (BTB and CNC homolog 2)	5	UniProt NCBI
NFE2L2	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)	5	UniProt NCBI
KRT18	Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)	5	UniProt NCBI
RTL6	Retrotransposon Gag-like protein 6 (Leucine zipper protein down-regulated in cancer cells-like) (Mammalian retrotransposon-derived protein 6) (Protein LDOC1L)	3	UniProt NCBI
FBXO22	F-box only protein 22 (F-box protein FBX22p44)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4269	4.28832438719e-09	0.285714285714	MAFG NFE2L2 MAFK MAFF	Ethanol metabolism production of ROS by CYP2E1
REAC:R-HSA-9707587	1.96338187373e-06	0.214285714286	NFE2L2 MAFK BACH1	Regulation of HMOX1 expression and activity
GO:0090575	1.52266394179e-05	0.5	BACH2 NFE2L3 MAFG MAFK MAFF BACH1 NFE2L2	RNA polymerase II transcription regulator complex
WP:WP2435	2.95026604181e-05	0.214285714286	NFE2L2 MAFK MAFG	Quercetin and Nf kB AP 1 induced apoptosis
REAC:R-HSA-9818027	0.000109268371341	0.214285714286	NFE2L2 MAFK BACH1	NFE2L2 regulating anti-oxidant/detoxification enzymes
REAC:R-HSA-9759194	0.000202676802324	0.285714285714	MAFG NFE2L2 MAFK BACH1	Nuclear events mediated by NFE2L2
GO:0000978	0.000219917597735	0.642857142857	CALCOCO1 MAFG NFE2L3 MAFK BACH1 MAFF BACH2 NFE2L1 NFE2L2	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000987	0.000263907699919	0.642857142857	CALCOCO1 MAFG NFE2L3 MAFK BACH1 MAFF BACH2 NFE2L1 NFE2L2	cis-regulatory region sequence-specific DNA binding
REAC:R-HSA-9755511	0.000644070617096	0.285714285714	MAFG NFE2L2 MAFK BACH1	KEAP1-NFE2L2 pathway
GO:0005667	0.000753224270847	0.5	BACH2 NFE2L3 MAFG MAFK MAFF BACH1 NFE2L2	transcription regulator complex
GO:0000977	0.000916990234428	0.642857142857	CALCOCO1 MAFG NFE2L3 MAFK BACH1 MAFF BACH2 NFE2L1 NFE2L2	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000976	0.00193052332818	0.642857142857	CALCOCO1 MAFG NFE2L3 MAFK BACH1 MAFF BACH2 NFE2L1 NFE2L2	transcription cis-regulatory region binding
GO:0001067	0.0019477802701	0.642857142857	CALCOCO1 MAFG NFE2L3 MAFK BACH1 MAFF BACH2 NFE2L1 NFE2L2	transcription regulatory region nucleic acid binding
REAC:R-HSA-9707616	0.00220733602789	0.214285714286	NFE2L2 MAFK BACH1	Heme signaling
GO:1990837	0.00290410408744	0.642857142857	CALCOCO1 MAFG NFE2L3 MAFK BACH1 MAFF BACH2 NFE2L1 NFE2L2	sequence-specific double-stranded DNA binding
GO:0043565	0.00540172587396	0.642857142857	CALCOCO1 MAFG NFE2L3 MAFK BACH1 MAFF BACH2 NFE2L1 NFE2L2	sequence-specific DNA binding
GO:0003690	0.0055305495206	0.642857142857	CALCOCO1 MAFG NFE2L3 MAFK BACH1 MAFF BACH2 NFE2L1 NFE2L2	double-stranded DNA binding
REAC:R-HSA-9711123	0.00606366923092	0.285714285714	MAFG NFE2L2 MAFK BACH1	Cellular response to chemical stress
REAC:R-HSA-9707564	0.00619094878017	0.214285714286	NFE2L2 MAFK BACH1	Cytoprotection by HMOX1
REAC:R-HSA-9818028	0.00668012550606	0.142857142857	MAFG NFE2L2	NFE2L2 regulates pentose phosphate pathway genes
REAC:R-HSA-9708530	0.0131001388031	0.142857142857	MAFK BACH1	Regulation of BACH1 activity
GO:0000981	0.0172292094179	0.571428571429	BACH2 NFE2L3 NFE2L2 MAFG BACH1 MAFF NFE2L1 MAFK	DNA-binding transcription factor activity, RNA polymerase II-specific
WP:WP2884	0.0174775848213	0.214285714286	NFE2L2 MAFF MAFG	NRF2 pathway
GO:0003700	0.0277666812551	0.571428571429	BACH2 NFE2L3 NFE2L2 MAFG BACH1 MAFF NFE2L1 MAFK	DNA-binding transcription factor activity
GO:0140110	0.0295551162235	0.642857142857	CALCOCO1 MAFG NFE2L3 MAFK BACH1 MAFF BACH2 NFE2L1 NFE2L2	transcription regulator activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
HMMR	BACH1	1.0	0.116
BACH1	MAFK	1.0	0.114
MAFF	NFE2L2	0.999		structurally_consistent (dimer)
BACH1	MAFG	0.999	0.062
MAFF	BACH2	0.999		structurally_consistent (dimer)
BACH1	MAFF	0.999	0.068	structurally_consistent (dimer)
NFE2L3	MAFF	0.998		structurally_consistent (dimer)
MAFF	NFE2L1	0.998		structurally_consistent (dimer)
RTL6	MAFF	0.997		mutually_exclusive (Q9NR55) structurally_consistent (dimer)
FBXO22	BACH1	0.995	0.034
CALCOCO1	MAFF	0.994	0.062	mutually_exclusive (O60675) structurally_consistent (dimer)
NFE2L3	MAFK	0.994
NFE2L3	MAFG	0.991
BACH1	BACH2	0.988
MAFK	MAFF	0.985	0.206	structurally_consistent (dimer)
CALCOCO1	BACH2	0.975
MAFK	MAFG	0.974	0.248
MAFK	BACH2	0.972
FBXO22	CYP4V2	0.96
MAFF	MAFG	0.956	0.208	structurally_consistent (dimer)
MAFK	NFE2L2	0.955
NFE2L3	NFE2L2	0.947
NFE2L1	NFE2L2	0.939
CALCOCO1	NFE2L1	0.918
MAFG	BACH2	0.913
NFE2L3	NFE2L1	0.908
BACH2	NFE2L2	0.908
NFE2L1	BACH2	0.904
HMMR	KRT18	0.901	0.142
BACH1	NFE2L2	0.888
CALCOCO1	NFE2L2	0.888
NFE2L3	BACH1	0.885
NFE2L3	BACH2	0.884
BACH1	NFE2L1	0.884
HMMR	MAFF	0.864	0.03
NFE2L3	CALCOCO1	0.862
FBXO22	MAFF	0.855	0.066
FBXO22	MAFK	0.842	0.052
RTL6	BACH1	0.84		mutually_exclusive (Q9ULX9)
HMMR	MAFG	0.833	0.108
FBXO22	MAFG	0.828	0.036
HMMR	MAFK	0.796	0.076
MAFK	NFE2L1	0.772		mutually_exclusive (Q9ULX9)
CALCOCO1	BACH1	0.696	0.092
FBXO22	HMMR	0.4	0.042
RTL6	NFE2L2	0.378		mutually_exclusive (Q9ULX9)
RTL6	BACH2	0.32		mutually_exclusive (Q9ULX9)
NFE2L3	RTL6	0.224		mutually_exclusive (Q9ULX9)
RTL6	NFE2L1	0.215		mutually_exclusive (Q9ULX9)
MAFG	NFE2L2	0.21
FBXO22	NFE2L3	0.173
CALCOCO1	MAFK	0.159	0.09	mutually_exclusive (Q9ULX9) structurally_consistent (dimer)
CALCOCO1	RTL6	0.152		mutually_exclusive (Q9ULX9)
HMMR	NFE2L1	0.102
FBXO22	NFE2L1	0.092
FBXO22	NFE2L2	0.091
CALCOCO1	MAFG	0.089	0.126
NFE2L1	MAFG	0.076
HMMR	CALCOCO1	0.046	0.114
FBXO22	BACH2	0.045
FBXO22	RTL6	0.026
FBXO22	CALCOCO1	0.013	0.024
CALCOCO1	KRT18	0.003	0.204
BACH2	KRT18	0.002

Related Complexes

Genename	Complexes
MAFK	huMAP3_04493.1 huMAP3_09866.1 huMAP3_13906.1
MAFF	huMAP3_04493.1 huMAP3_06424.1 huMAP3_09866.1 huMAP3_13906.1
CALCOCO1	huMAP3_02419.1 huMAP3_06283.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_13906.1
NFE2L3	huMAP3_02029.1 huMAP3_04493.1 huMAP3_06546.1 huMAP3_09866.1 huMAP3_10106.1 huMAP3_13906.1
BACH1	huMAP3_04435.1 huMAP3_09866.1 huMAP3_13906.1
CYP4V2	huMAP3_02627.1 huMAP3_13906.1
NFE2L1	huMAP3_04493.1 huMAP3_09866.1 huMAP3_13906.1
HMMR	huMAP3_02248.1 huMAP3_05467.1 huMAP3_07813.1 huMAP3_09634.1 huMAP3_10849.1 huMAP3_10951.1 huMAP3_12566.1 huMAP3_13906.1
MAFG	huMAP3_04493.1 huMAP3_09866.1 huMAP3_13906.1
BACH2	huMAP3_04493.1 huMAP3_09866.1 huMAP3_13906.1 huMAP3_15260.1
NFE2L2	huMAP3_04493.1 huMAP3_09866.1 huMAP3_13906.1
KRT18	huMAP3_11834.1 huMAP3_12566.1 huMAP3_12711.1 huMAP3_12963.1 huMAP3_13906.1
RTL6	huMAP3_02629.1 huMAP3_06424.1 huMAP3_07942.1 huMAP3_08058.1 huMAP3_09715.1 huMAP3_11017.1 huMAP3_13906.1
FBXO22	huMAP3_00161.1 huMAP3_02627.1 huMAP3_09623.1 huMAP3_13906.1 huMAP3_14622.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13906.1

Complex Portal: CPX-20264