hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13909.1
Complex Portal: CPX-10571
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LRRC8E | Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E) | 5 | UniProt NCBI |
| NPEPPS | Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) | 5 | UniProt NCBI |
| LRRC8D | Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) | 5 | UniProt NCBI |
| LRRC8C | Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C) | 5 | UniProt NCBI |
| LRRC8B | Volume-regulated anion channel subunit LRRC8B (Leucine-rich repeat-containing protein 8B) (T-cell activation leucine repeat-rich protein) (TA-LRRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6567 | 1.91772524101e-12 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | SWELL1-containing complex |
| REAC:R-HSA-5223345 | 2.06774373342e-09 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | Miscellaneous transport and binding events |
| GO:0005225 | 1.65724193228e-08 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | volume-sensitive anion channel activity |
| WP:WP5083 | 9.84065594112e-07 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | Neuroinflammation and glutamatergic signaling |
| GO:0098656 | 1.95582475037e-05 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | monoatomic anion transmembrane transport |
| GO:0005253 | 4.81842507515e-05 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | monoatomic anion channel activity |
| GO:0006820 | 0.000150799788408 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | monoatomic anion transport |
| GO:0008509 | 0.000217964056115 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | monoatomic anion transmembrane transporter activity |
| REAC:R-HSA-382551 | 0.00137916640811 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | Transport of small molecules |
| GO:0034702 | 0.00407551040215 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | monoatomic ion channel complex |
| GO:1902495 | 0.0187071120569 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | transmembrane transporter complex |
| GO:0005216 | 0.0252691756905 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | monoatomic ion channel activity |
| GO:1990351 | 0.025656507175 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | transporter complex |
| GO:0140361 | 0.0280843539964 | 0.4 | LRRC8E LRRC8C | cyclic-GMP-AMP transmembrane import across plasma membrane |
| GO:1903790 | 0.0280843539964 | 0.4 | LRRC8E LRRC8C | guanine nucleotide transmembrane transport |
| GO:0015267 | 0.0384230454852 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | channel activity |
| GO:0022803 | 0.0389526852651 | 0.8 | LRRC8B LRRC8D LRRC8E LRRC8C | passive transmembrane transporter activity |
| GO:0001408 | 0.0468008499735 | 0.4 | LRRC8E LRRC8C | guanine nucleotide transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NPEPPS | LRRC8E | 0.999 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LRRC8B | LRRC8E | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| LRRC8C | LRRC8B | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRRC8D | LRRC8B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NPEPPS | LRRC8B | 0.983 |
structurally_consistent (Q8TDW0)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPEPPS | LRRC8D | 0.946 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NPEPPS | LRRC8C | 0.855 | 0.03 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| LRRC8C | LRRC8E | 0.848 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRRC8D | LRRC8E | 0.408 | 0.138 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRRC8D | LRRC8C | 0.396 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes