hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13917.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FGF4 | Fibroblast growth factor 4 (FGF-4) (Heparin secretory-transforming protein 1) (HST) (HST-1) (HSTF-1) (Heparin-binding growth factor 4) (HBGF-4) (Transforming protein KS3) | 5 | UniProt NCBI |
| FGF2 | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) | 5 | UniProt NCBI |
| GPC1 | Glypican-1 [Cleaved into: Secreted glypican-1] | 5 | UniProt NCBI |
| IL7R | Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) | 5 | UniProt NCBI |
| DHRS2 | Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) (Protein SDR25C1) | 5 | UniProt NCBI |
| METTL8 | tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial (EC 2.1.1.-) (Methyltransferase-like protein 8) (mRNA N(3)-methylcytidine methyltransferase METTL8) (EC 2.1.1.-) | 5 | UniProt NCBI |
| USF3 | Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3) | 5 | UniProt NCBI |
| GPC3 | Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit] | 5 | UniProt NCBI |
| EDA2R | Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor) | 5 | UniProt NCBI |
| SDC4 | Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) | 5 | UniProt NCBI |
| AMPD2 | AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) | 5 | UniProt NCBI |
| OPN3 | Opsin-3 (Encephalopsin) (Panopsin) | 5 | UniProt NCBI |
| GPC6 | Glypican-6 [Cleaved into: Secreted glypican-6] | 5 | UniProt NCBI |
| TMEFF1 | Tomoregulin-1 (TR-1) (H7365) (Transmembrane protein with EGF-like and one follistatin-like domain) | 5 | UniProt NCBI |
| HADHA | Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] | 5 | UniProt NCBI |
| CD44 | CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) | 5 | UniProt NCBI |
| GMEB2 | Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79) | 5 | UniProt NCBI |
| GMEB1 | Glucocorticoid modulatory element-binding protein 1 (GMEB-1) (DNA-binding protein p96PIF) (Parvovirus initiation factor p96) (PIF p96) | 5 | UniProt NCBI |
| HADHB | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] | 5 | UniProt NCBI |
| EGFLAM | Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein) | 5 | UniProt NCBI |
| SDC1 | Syndecan-1 (SYND1) (CD antigen CD138) | 5 | UniProt NCBI |
| PRDM10 | PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin) | 5 | UniProt NCBI |
| IRAK3 | Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3) | 5 | UniProt NCBI |
| CEACAM7 | Carcinoembryonic antigen-related cell adhesion molecule 7 (CEA cell adhesion molecule 7) (Carcinoembryonic antigen CGM2) | 5 | UniProt NCBI |
| GPC4 | Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4] | 5 | UniProt NCBI |
| HBEGF | Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)] | 5 | UniProt NCBI |
| FGF1 | Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) | 5 | UniProt NCBI |
| ALK | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) | 5 | UniProt NCBI |
| SYNDIG1 | Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B) | 5 | UniProt NCBI |
| SDC2 | Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362) | 5 | UniProt NCBI |
| KLHL7 | Kelch-like protein 7 | 5 | UniProt NCBI |
| MPV17L2 | Mpv17-like protein 2 | 4 | UniProt NCBI |
| MTNAP1 | Mitochondrial nucleoid-associated protein 1 (Cell migration-inducing gene 3 protein) (Human lung cancer oncogene 8 protein) (HLC-8) (Protein C17orf80) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656253 | 4.43525863812e-11 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-3656237 | 4.43525863812e-11 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-9694614 | 1.82015128998e-10 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Attachment and Entry |
| REAC:R-HSA-3560783 | 2.72638112172e-10 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-4420332 | 2.72638112172e-10 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560801 | 2.72638112172e-10 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-2024096 | 1.08963388046e-09 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 1.96007948506e-09 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 5.45549179831e-09 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | HS-GAG biosynthesis |
| REAC:R-HSA-9772572 | 1.59257707896e-08 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Early SARS-CoV-2 Infection Events |
| REAC:R-HSA-3560782 | 3.94170131321e-08 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 5.46500160388e-08 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 8.64334302558e-08 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 1.32238687964e-07 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1638091 | 2.23078876242e-07 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Heparan sulfate/heparin (HS-GAG) metabolism |
| REAC:R-HSA-2187338 | 3.46603199764e-06 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Visual phototransduction |
| REAC:R-HSA-1630316 | 2.76251661928e-05 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Glycosaminoglycan metabolism |
| REAC:R-HSA-3781865 | 3.0769677677e-05 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Diseases of glycosylation |
| REAC:R-HSA-1839122 | 5.2874449752e-05 | 0.1 | FGF4 FGF2 FGF1 | Signaling by activated point mutants of FGFR1 |
| REAC:R-HSA-190375 | 5.2874449752e-05 | 0.1 | FGF4 FGF2 FGF1 | FGFR2c ligand binding and activation |
| REAC:R-HSA-190373 | 5.2874449752e-05 | 0.1 | FGF4 FGF2 FGF1 | FGFR1c ligand binding and activation |
| REAC:R-HSA-190239 | 9.24020687783e-05 | 0.1 | FGF4 FGF2 FGF1 | FGFR3 ligand binding and activation |
| REAC:R-HSA-5654227 | 9.24020687783e-05 | 0.1 | FGF4 FGF2 FGF1 | Phospholipase C-mediated cascade; FGFR3 |
| REAC:R-HSA-2033514 | 9.24020687783e-05 | 0.1 | FGF4 FGF2 FGF1 | FGFR3 mutant receptor activation |
| REAC:R-HSA-1839130 | 9.24020687783e-05 | 0.1 | FGF4 FGF2 FGF1 | Signaling by activated point mutants of FGFR3 |
| REAC:R-HSA-190372 | 9.24020687783e-05 | 0.1 | FGF4 FGF2 FGF1 | FGFR3c ligand binding and activation |
| WP:WP2848 | 9.65924809809e-05 | 0.133333333333 | FGF4 FGF2 ALK FGF1 | Pluripotent stem cell differentiation pathway |
| KEGG:05205 | 0.00010105293015 | 0.2 | SDC4 HBEGF GPC3 FGF2 GPC1 SDC1 | Proteoglycans in cancer |
| REAC:R-HSA-5654219 | 0.00014763845283 | 0.1 | FGF4 FGF2 FGF1 | Phospholipase C-mediated cascade: FGFR1 |
| REAC:R-HSA-190242 | 0.00014763845283 | 0.1 | FGF4 FGF2 FGF1 | FGFR1 ligand binding and activation |
| REAC:R-HSA-190322 | 0.00014763845283 | 0.1 | FGF4 FGF2 FGF1 | FGFR4 ligand binding and activation |
| REAC:R-HSA-5654221 | 0.000221150830866 | 0.1 | FGF4 FGF2 FGF1 | Phospholipase C-mediated cascade; FGFR2 |
| REAC:R-HSA-5654704 | 0.000221150830866 | 0.1 | FGF4 FGF2 FGF1 | SHC-mediated cascade:FGFR3 |
| REAC:R-HSA-2033519 | 0.000221150830866 | 0.1 | FGF4 FGF2 FGF1 | Activated point mutants of FGFR2 |
| REAC:R-HSA-5654228 | 0.000221150830866 | 0.1 | FGF4 FGF2 FGF1 | Phospholipase C-mediated cascade; FGFR4 |
| REAC:R-HSA-196854 | 0.000227888645321 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Metabolism of vitamins and cofactors |
| REAC:R-HSA-5654710 | 0.000315492027581 | 0.1 | FGF4 FGF2 FGF1 | PI-3K cascade:FGFR3 |
| REAC:R-HSA-5654706 | 0.000315492027581 | 0.1 | FGF4 FGF2 FGF1 | FRS-mediated FGFR3 signaling |
| REAC:R-HSA-5654688 | 0.000315492027581 | 0.1 | FGF4 FGF2 FGF1 | SHC-mediated cascade:FGFR1 |
| REAC:R-HSA-190241 | 0.000315492027581 | 0.1 | FGF4 FGF2 FGF1 | FGFR2 ligand binding and activation |
| REAC:R-HSA-5654693 | 0.000433200514889 | 0.1 | FGF4 FGF2 FGF1 | FRS-mediated FGFR1 signaling |
| REAC:R-HSA-5654719 | 0.000433200514889 | 0.1 | FGF4 FGF2 FGF1 | SHC-mediated cascade:FGFR4 |
| REAC:R-HSA-5654689 | 0.000433200514889 | 0.1 | FGF4 FGF2 FGF1 | PI-3K cascade:FGFR1 |
| REAC:R-HSA-5654699 | 0.000433200514889 | 0.1 | FGF4 FGF2 FGF1 | SHC-mediated cascade:FGFR2 |
| GO:0005796 | 0.000434892557699 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Golgi lumen |
| CORUM:7262 | 0.000483770340229 | 0.0666666666667 | HADHA HADHB | 3-Hydroxyacyl CoA dehydrogenase |
| REAC:R-HSA-5654695 | 0.000576800463262 | 0.1 | FGF4 FGF2 FGF1 | PI-3K cascade:FGFR2 |
| REAC:R-HSA-5654700 | 0.000576800463262 | 0.1 | FGF4 FGF2 FGF1 | FRS-mediated FGFR2 signaling |
| REAC:R-HSA-5654712 | 0.000576800463262 | 0.1 | FGF4 FGF2 FGF1 | FRS-mediated FGFR4 signaling |
| REAC:R-HSA-5654720 | 0.000576800463262 | 0.1 | FGF4 FGF2 FGF1 | PI-3K cascade:FGFR4 |
| REAC:R-HSA-5668914 | 0.000633473000045 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Diseases of metabolism |
| GO:0043202 | 0.000799518213356 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | lysosomal lumen |
| REAC:R-HSA-5655332 | 0.000951700224869 | 0.1 | FGF4 FGF2 FGF1 | Signaling by FGFR3 in disease |
| REAC:R-HSA-5654708 | 0.000951700224869 | 0.1 | FGF4 FGF2 FGF1 | Downstream signaling of activated FGFR3 |
| REAC:R-HSA-2219530 | 0.00105806534003 | 0.133333333333 | FGF4 FGF2 FGF1 HBEGF | Constitutive Signaling by Aberrant PI3K in Cancer |
| REAC:R-HSA-9709957 | 0.00117413618692 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Sensory Perception |
| REAC:R-HSA-5654716 | 0.00146010058888 | 0.1 | FGF4 FGF2 FGF1 | Downstream signaling of activated FGFR4 |
| REAC:R-HSA-5654696 | 0.00146010058888 | 0.1 | FGF4 FGF2 FGF1 | Downstream signaling of activated FGFR2 |
| REAC:R-HSA-5654687 | 0.00146010058888 | 0.1 | FGF4 FGF2 FGF1 | Downstream signaling of activated FGFR1 |
| REAC:R-HSA-5654732 | 0.00295591403648 | 0.1 | FGF4 FGF2 FGF1 | Negative regulation of FGFR3 signaling |
| REAC:R-HSA-71387 | 0.0038652434849 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | Metabolism of carbohydrates |
| GO:0035766 | 0.00389166490199 | 0.1 | FGF4 FGF2 FGF1 | cell chemotaxis to fibroblast growth factor |
| GO:0035768 | 0.00389166490199 | 0.1 | FGF4 FGF2 FGF1 | endothelial cell chemotaxis to fibroblast growth factor |
| GO:1904847 | 0.00389166490199 | 0.1 | FGF4 FGF2 FGF1 | regulation of cell chemotaxis to fibroblast growth factor |
| GO:2000544 | 0.00389166490199 | 0.1 | FGF4 FGF2 FGF1 | regulation of endothelial cell chemotaxis to fibroblast growth factor |
| REAC:R-HSA-5654733 | 0.0039820243215 | 0.1 | FGF4 FGF2 FGF1 | Negative regulation of FGFR4 signaling |
| REAC:R-HSA-5654726 | 0.0039820243215 | 0.1 | FGF4 FGF2 FGF1 | Negative regulation of FGFR1 signaling |
| REAC:R-HSA-5654727 | 0.0039820243215 | 0.1 | FGF4 FGF2 FGF1 | Negative regulation of FGFR2 signaling |
| REAC:R-HSA-3000170 | 0.0039820243215 | 0.1 | SDC4 FGF2 SDC1 | Syndecan interactions |
| REAC:R-HSA-77305 | 0.00415116629235 | 0.0666666666667 | HADHA HADHB | Beta oxidation of palmitoyl-CoA to myristoyl-CoA |
| REAC:R-HSA-77285 | 0.00415116629235 | 0.0666666666667 | HADHA HADHB | Beta oxidation of myristoyl-CoA to lauroyl-CoA |
| HP:0025144 | 0.00496749544479 | 0.0666666666667 | HADHA HADHB | Shivering |
| HP:5201010 | 0.00496749544479 | 0.0666666666667 | GPC3 GPC4 | Microform cleft of the upper lip |
| HP:0006176 | 0.00496749544479 | 0.0666666666667 | GPC3 GPC4 | Two carpal ossification centers present at birth |
| HP:0009101 | 0.00496749544479 | 0.0666666666667 | GPC3 GPC4 | Submucous cleft lip |
| HP:0025145 | 0.00496749544479 | 0.0666666666667 | HADHA HADHB | Rigors |
| REAC:R-HSA-6811558 | 0.00510865753393 | 0.133333333333 | FGF4 FGF2 FGF1 HBEGF | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-1839124 | 0.00521903281823 | 0.1 | FGF4 FGF2 FGF1 | FGFR1 mutant receptor activation |
| REAC:R-HSA-1839126 | 0.00521903281823 | 0.1 | FGF4 FGF2 FGF1 | FGFR2 mutant receptor activation |
| REAC:R-HSA-9694516 | 0.00556977921537 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | SARS-CoV-2 Infection |
| REAC:R-HSA-2219528 | 0.0056800702397 | 0.133333333333 | FGF4 FGF2 FGF1 HBEGF | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-199418 | 0.00731355081651 | 0.133333333333 | FGF4 FGF2 FGF1 HBEGF | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-109704 | 0.00751103980414 | 0.1 | FGF4 FGF2 FGF1 | PI3K Cascade |
| REAC:R-HSA-190370 | 0.00829172832501 | 0.0666666666667 | FGF1 FGF2 | FGFR1b ligand binding and activation |
| REAC:R-HSA-5654741 | 0.00840071705559 | 0.1 | FGF4 FGF2 FGF1 | Signaling by FGFR3 |
| REAC:R-HSA-5654743 | 0.00935705758502 | 0.1 | FGF4 FGF2 FGF1 | Signaling by FGFR4 |
| REAC:R-HSA-5655302 | 0.00935705758502 | 0.1 | FGF4 FGF2 FGF1 | Signaling by FGFR1 in disease |
| REAC:R-HSA-112399 | 0.0103823367499 | 0.1 | FGF4 FGF2 FGF1 | IRS-mediated signalling |
| REAC:R-HSA-5655253 | 0.0114788165542 | 0.1 | FGF4 FGF2 FGF1 | Signaling by FGFR2 in disease |
| REAC:R-HSA-5654736 | 0.0126487456967 | 0.1 | FGF4 FGF2 FGF1 | Signaling by FGFR1 |
| REAC:R-HSA-77310 | 0.0138018979344 | 0.0666666666667 | HADHA HADHB | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA |
| REAC:R-HSA-77348 | 0.0138018979344 | 0.0666666666667 | HADHA HADHB | Beta oxidation of octanoyl-CoA to hexanoyl-CoA |
| REAC:R-HSA-77350 | 0.0138018979344 | 0.0666666666667 | HADHA HADHB | Beta oxidation of hexanoyl-CoA to butanoyl-CoA |
| REAC:R-HSA-2404192 | 0.0138943596197 | 0.1 | FGF4 FGF2 FGF1 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-2428928 | 0.0138943596197 | 0.1 | FGF4 FGF2 FGF1 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2428924 | 0.0138943596197 | 0.1 | FGF4 FGF2 FGF1 | IGF1R signaling cascade |
| HP:0008416 | 0.0148834498774 | 0.0666666666667 | GPC3 GPC4 | Six lumbar vertebrae |
| HP:0004464 | 0.0148834498774 | 0.0666666666667 | GPC3 GPC4 | Postauricular pit |
| KEGG:05218 | 0.0172819191925 | 0.1 | FGF4 FGF2 FGF1 | Melanoma |
| REAC:R-HSA-74751 | 0.0181074666528 | 0.1 | FGF4 FGF2 FGF1 | Insulin receptor signalling cascade |
| REAC:R-HSA-5658623 | 0.0206764096767 | 0.0666666666667 | FGF4 FGF2 | FGFRL1 modulation of FGFR1 signaling |
| REAC:R-HSA-190377 | 0.0206764096767 | 0.0666666666667 | FGF1 FGF2 | FGFR2b ligand binding and activation |
| REAC:R-HSA-77346 | 0.0206764096767 | 0.0666666666667 | HADHA HADHB | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA |
| REAC:R-HSA-1482798 | 0.0206764096767 | 0.0666666666667 | HADHA HADHB | Acyl chain remodeling of CL |
| REAC:R-HSA-77288 | 0.0206764096767 | 0.0666666666667 | HADHA HADHB | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids |
| HP:0002711 | 0.0297288796043 | 0.0666666666667 | GPC3 GPC4 | Exaggerated median tongue furrow |
| HP:0003185 | 0.0297288796043 | 0.0666666666667 | GPC3 GPC4 | Short greater sciatic notch |
| HP:0005580 | 0.0297288796043 | 0.0666666666667 | GPC3 GPC4 | Duplication of renal pelvis |
| HP:0006555 | 0.0297288796043 | 0.0666666666667 | HADHA HADHB | Diffuse hepatic steatosis |
| GO:0009986 | 0.0312779483076 | 0.3 | SDC4 GPC6 GPC3 GPC4 CEACAM7 GPC1 SDC1 EGFLAM HBEGF | cell surface |
| REAC:R-HSA-9679506 | 0.0333419876019 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | SARS-CoV Infections |
| GO:0005775 | 0.0334996308621 | 0.2 | SDC4 GPC6 GPC3 GPC1 SDC1 GPC4 | vacuolar lumen |
| REAC:R-HSA-1643685 | 0.0342799707765 | 0.366666666667 | SDC4 GPC6 FGF4 GPC3 FGF2 FGF1 GPC1 SDC1 GPC4 ALK HBEGF | Disease |
| WP:WP3871 | 0.0354850283616 | 0.0666666666667 | HADHA HADHB | Valproic acid pathway |
| REAC:R-HSA-3000171 | 0.0431408337791 | 0.1 | SDC4 FGF2 SDC1 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-1226099 | 0.0487524554093 | 0.1 | FGF4 FGF2 FGF1 | Signaling by FGFR in disease |
| HP:0002946 | 0.0494848535697 | 0.0666666666667 | GPC3 GPC4 | Supernumerary vertebrae |
| HP:0009908 | 0.0494848535697 | 0.0666666666667 | GPC3 GPC4 | Anterior creases of earlobe |
| HP:0030304 | 0.0494848535697 | 0.0666666666667 | GPC3 GPC4 | Abnormal number of vertebrae |
| HP:0003517 | 0.0494848535697 | 0.0666666666667 | GPC3 GPC4 | Birth length greater than 97th percentile |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| GMEB2 | GMEB1 | 1.0 | |
| HADHB | HADHA | 1.0 | 0.968 |
| SDC2 | SDC4 | 0.999 | 0.108 |
| SDC2 | FGF2 | 0.999 | 0.126 |
| SDC2 | USF3 | 0.999 | |
| SDC2 | GMEB1 | 0.999 | |
| SDC1 | PRDM10 | 0.998 | 0.082 |
| SDC4 | HADHA | 0.998 | 0.142 |
| SDC2 | HADHA | 0.998 | 0.176 |
| SDC2 | PRDM10 | 0.998 | 0.146 |
| SDC2 | DHRS2 | 0.997 | 0.13 |
| SDC2 | GMEB2 | 0.997 | 0.102 |
| SDC2 | HADHB | 0.997 | 0.144 |
| SDC2 | METTL8 | 0.997 | 0.084 |
| SDC1 | HADHA | 0.996 | 0.118 |
| FGF4 | SDC1 | 0.996 | |
| SDC1 | FGF2 | 0.994 | 0.098 |
| FGF4 | SDC4 | 0.994 | |
| SDC1 | DHRS2 | 0.994 | 0.04 |
| GPC1 | HADHA | 0.993 | 0.314 |
| MTNAP1 | HADHB | 0.993 | 0.424 |
| FGF2 | GMEB2 | 0.992 | 0.104 |
| FGF2 | GMEB1 | 0.992 | |
| FGF1 | SDC4 | 0.991 | 0.102 |
| HADHA | CD44 | 0.991 | 0.268 |
| GPC4 | GPC1 | 0.99 | 0.136 |
| FGF2 | DHRS2 | 0.99 | 0.102 |
| HADHB | GPC1 | 0.99 | 0.222 |
| PRDM10 | CD44 | 0.989 | 0.168 |
| MTNAP1 | HADHA | 0.989 | 0.302 |
| GPC1 | FGF1 | 0.989 | 0.172 |
| GMEB2 | CD44 | 0.988 | 0.05 |
| TMEFF1 | HADHB | 0.987 | |
| GPC4 | FGF4 | 0.987 | |
| PRDM10 | SDC4 | 0.987 | 0.042 |
| SDC1 | HADHB | 0.986 | 0.082 |
| HBEGF | GPC1 | 0.986 | |
| FGF2 | IL7R | 0.985 | |
| SDC1 | GMEB2 | 0.984 | 0.0844222222222 |
| AMPD2 | SDC2 | 0.984 | 0.144 |
| FGF4 | GPC1 | 0.984 | |
| GPC1 | CEACAM7 | 0.984 | |
| TMEFF1 | DHRS2 | 0.983 | |
| KLHL7 | FGF4 | 0.983 | |
| GMEB2 | DHRS2 | 0.982 | 0.046 |
| GMEB1 | DHRS2 | 0.982 | |
| TMEFF1 | FGF2 | 0.98 | |
| HADHB | SDC4 | 0.98 | 0.054 |
| SDC2 | FGF4 | 0.98 | |
| FGF2 | CD44 | 0.979 | 0.124 |
| SDC2 | SDC1 | 0.978 | 0.124 |
| GMEB1 | CD44 | 0.978 | |
| FGF2 | PRDM10 | 0.976 | 0.076 |
| SDC2 | GPC1 | 0.976 | 0.126 |
| KLHL7 | FGF1 | 0.974 | 0.144 |
| GMEB2 | SDC4 | 0.974 | 0.12 |
| GPC4 | HBEGF | 0.973 | |
| SDC1 | FGF1 | 0.972 | 0.12 |
| PRDM10 | DHRS2 | 0.971 | 0.128 |
| GPC6 | GPC4 | 0.97 | 0.146 |
| HADHB | CD44 | 0.969 | 0.336 |
| GPC1 | SDC4 | 0.969 | 0.106 |
| MTNAP1 | CD44 | 0.969 | 0.12 |
| FGF2 | SDC4 | 0.966 | 0.108 |
| HADHB | FGF2 | 0.96 | 0.164 |
| GPC4 | HADHA | 0.957 | 0.138 |
| GPC4 | FGF1 | 0.957 | 0.076 |
| GPC4 | SDC4 | 0.951 | 0.096 |
| GMEB1 | SDC4 | 0.951 | |
| HADHB | OPN3 | 0.949 | |
| GPC1 | GPC3 | 0.948 | |
| SDC4 | DHRS2 | 0.946 | 0.024 |
| TMEFF1 | PRDM10 | 0.946 | |
| METTL8 | CD44 | 0.944 | 0.07 |
| HBEGF | CD44 | 0.936 | |
| METTL8 | SDC4 | 0.936 | 0.072 |
| EGFLAM | FGF1 | 0.931 | |
| SDC2 | GPC3 | 0.931 | |
| KLHL7 | SDC2 | 0.931 | 0.102 |
| TMEFF1 | HADHA | 0.928 | |
| FGF2 | HADHA | 0.926 | 0.122194029851 |
| SDC2 | FGF1 | 0.924 | 0.134 |
| IL7R | GMEB1 | 0.92 | |
| DHRS2 | CD44 | 0.918 | 0.064 |
| GPC4 | GPC3 | 0.916 | |
| SDC1 | SDC4 | 0.907 | 0.204 |
| HADHA | DHRS2 | 0.906 | 0.044 |
| USF3 | METTL8 | 0.904 | |
| USF3 | GMEB1 | 0.904 | |
| USF3 | FGF2 | 0.902 | |
| USF3 | GMEB2 | 0.902 | |
| METTL8 | GMEB2 | 0.9 | 0.082 |
| MTNAP1 | SDC4 | 0.899 | 0.066 |
| HADHA | OPN3 | 0.896 | |
| FGF4 | HADHA | 0.896 | |
| CD44 | IRAK3 | 0.893 | 0.08 |
| IL7R | DHRS2 | 0.892 | |
| MPV17L2 | HADHA | 0.892 | 0.196 |
| SDC4 | CD44 | 0.889 | 0.096 |
| AMPD2 | SDC4 | 0.887 | 0.138 |
| AMPD2 | CD44 | 0.886 | 0.074 |
| FGF1 | GPC3 | 0.881 | |
| IL7R | GMEB2 | 0.881 | |
| AMPD2 | GMEB2 | 0.879 | 0.05 |
| USF3 | DHRS2 | 0.869 | |
| METTL8 | DHRS2 | 0.867 | 0.084 |
| METTL8 | GMEB1 | 0.863 | |
| METTL8 | FGF2 | 0.854 | 0.124 |
| SDC1 | GMEB1 | 0.847 | |
| CD44 | EDA2R | 0.843 | |
| GPC4 | SDC1 | 0.842 | 0.142 |
| AMPD2 | FGF2 | 0.839 | 0.0722197802198 |
| HADHB | GMEB2 | 0.837 | 0.03 |
| AMPD2 | GMEB1 | 0.834 | |
| GMEB2 | PRDM10 | 0.834 | 0.166 |
| HADHB | SYNDIG1 | 0.833 | |
| FGF4 | CD44 | 0.811 | |
| HADHA | GPC3 | 0.81 | |
| SDC2 | ALK | 0.805 | |
| AMPD2 | METTL8 | 0.805 | 0.064 |
| AMPD2 | DHRS2 | 0.799 | 0.03 |
| AMPD2 | SDC1 | 0.794 | 0.064 |
| SDC1 | GPC1 | 0.793 | 0.272 |
| HADHB | DHRS2 | 0.791 | 0.056 |
| CD44 | ALK | 0.737 | |
| HADHB | GPC3 | 0.734 | |
| MTNAP1 | IL7R | 0.718 | |
| USF3 | SDC4 | 0.714 | |
| KLHL7 | SDC4 | 0.711 | 0.048 |
| FGF1 | CD44 | 0.708 | 0.108 |
| GPC4 | SDC2 | 0.692 | 0.126 |
| USF3 | SDC1 | 0.688 | |
| FGF4 | GPC3 | 0.688 | |
| KLHL7 | METTL8 | 0.68 | 0.112 |
| KLHL7 | FGF2 | 0.673 | 0.104 |
| KLHL7 | GMEB2 | 0.64 | 0.1 |
| GPC1 | ALK | 0.626 | |
| KLHL7 | GMEB1 | 0.621 | |
| IL7R | PRDM10 | 0.616 | |
| KLHL7 | DHRS2 | 0.613 | 0.04 |
| METTL8 | PRDM10 | 0.608 | 0.11 |
| GMEB1 | PRDM10 | 0.601 | |
| HADHB | METTL8 | 0.594 | 0.15 |
| PRDM10 | GPC3 | 0.575 | |
| GPC3 | ALK | 0.558 | |
| SDC4 | GPC3 | 0.552 | |
| GPC4 | KLHL7 | 0.55 | 0.116 |
| METTL8 | HADHA | 0.545 | 0.146 |
| MTNAP1 | GPC1 | 0.532 | 0.034 |
| HADHB | PRDM10 | 0.53 | 0.174 |
| GPC6 | GPC3 | 0.498 | |
| AMPD2 | IL7R | 0.482 | |
| AMPD2 | PRDM10 | 0.466 | 0.094 |
| KLHL7 | USF3 | 0.455 | |
| TMEFF1 | MPV17L2 | 0.415 | |
| HADHB | IL7R | 0.411 | |
| GPC6 | HADHA | 0.407 | 0.082 |
| GPC4 | MTNAP1 | 0.407 | 0.094 |
| AMPD2 | USF3 | 0.405 | |
| GPC4 | CD44 | 0.402 | 0.132 |
| KLHL7 | HADHA | 0.393 | 0.138 |
| USF3 | HADHB | 0.389 | |
| GMEB2 | HADHA | 0.363 | 0.072 |
| EGFLAM | SDC4 | 0.357 | |
| TMEFF1 | SDC4 | 0.357 | |
| SDC1 | METTL8 | 0.356 | 0.058 |
| USF3 | PRDM10 | 0.356 | |
| KLHL7 | GPC1 | 0.348 | 0.068 |
| KLHL7 | CD44 | 0.348 | 0.078 |
| GPC6 | GPC1 | 0.347 | 0.228 |
| KLHL7 | SDC1 | 0.346 | 0.098 |
| GPC6 | SDC4 | 0.333 | 0.086 |
| HADHB | GMEB1 | 0.323 | |
| SDC2 | EGFLAM | 0.3 | |
| TMEFF1 | GPC1 | 0.3 | |
| EGFLAM | GPC1 | 0.3 | |
| TMEFF1 | SDC2 | 0.3 | |
| GPC6 | ALK | 0.284 | |
| MPV17L2 | EGFLAM | 0.274 | |
| TMEFF1 | EGFLAM | 0.274 | |
| GPC6 | SDC2 | 0.266 | 0.13 |
| TMEFF1 | SDC1 | 0.265 | |
| KLHL7 | PRDM10 | 0.263 | 0.092 |
| IL7R | HADHA | 0.241 | |
| EGFLAM | GPC3 | 0.233 | |
| SDC1 | GPC3 | 0.233 | |
| TMEFF1 | GPC3 | 0.233 | |
| GMEB1 | HADHA | 0.223 | |
| GPC6 | SDC1 | 0.22 | 0.092 |
| MTNAP1 | GMEB2 | 0.21 | 0.112 |
| GPC1 | CD44 | 0.208 | 0.184 |
| MPV17L2 | HADHB | 0.2 | 0.154 |
| GPC6 | FGF1 | 0.199 | 0.144 |
| GPC6 | TMEFF1 | 0.184 | |
| AMPD2 | HADHA | 0.178 | 0.124 |
| SDC1 | CD44 | 0.176 | 0.094 |
| AMPD2 | KLHL7 | 0.166 | 0.072 |
| USF3 | HADHA | 0.154 | |
| SDC1 | MTNAP1 | 0.152 | 0.068 |
| AMPD2 | HADHB | 0.151 | 0.066 |
| PRDM10 | HADHA | 0.144 | 0.172 |
| MTNAP1 | DHRS2 | 0.143 | 0.054 |
| KLHL7 | HADHB | 0.138 | 0.056 |
| MTNAP1 | FGF2 | 0.128 | 0.074 |
| GPC4 | EGFLAM | 0.12 | |
| GPC4 | HADHB | 0.113 | 0.162 |
| EGFLAM | SDC1 | 0.106 | |
| GPC4 | TMEFF1 | 0.102 | |
| GPC6 | MPV17L2 | 0.102 | 0.056 |
| MTNAP1 | GMEB1 | 0.098 | |
| MPV17L2 | GPC3 | 0.087 | |
| GPC1 | PRDM10 | 0.087 | 0.038 |
| GPC6 | MTNAP1 | 0.079 | 0.112 |
| MPV17L2 | SDC4 | 0.078 | 0.048 |
| AMPD2 | MTNAP1 | 0.077 | 0.102 |
| MPV17L2 | DHRS2 | 0.076 | 0.072 |
| MPV17L2 | GPC1 | 0.076 | 0.06 |
| EGFLAM | DHRS2 | 0.076 | |
| MPV17L2 | SDC2 | 0.076 | 0.064 |
| MPV17L2 | SDC1 | 0.076 | 0.07 |
| CD44 | GPC3 | 0.074 | |
| GPC6 | CD44 | 0.071 | 0.12 |
| GPC6 | DHRS2 | 0.071 | 0.064 |
| GPC6 | EGFLAM | 0.07 | |
| MTNAP1 | METTL8 | 0.064 | 0.112 |
| EGFLAM | HADHB | 0.064 | |
| SDC2 | CD44 | 0.061 | 0.092 |
| GPC1 | DHRS2 | 0.061 | 0.036 |
| GPC4 | MPV17L2 | 0.061 | 0.084 |
| EGFLAM | MTNAP1 | 0.06 | |
| SDC2 | MTNAP1 | 0.059 | 0.082 |
| GPC4 | ALK | 0.056 | |
| TMEFF1 | MTNAP1 | 0.055 | |
| MPV17L2 | MTNAP1 | 0.055 | 0.198 |
| MTNAP1 | PRDM10 | 0.054 | 0.104 |
| DHRS2 | GPC3 | 0.052 | |
| HADHA | SYNDIG1 | 0.05 | |
| EGFLAM | HADHA | 0.046 | |
| KLHL7 | GPC3 | 0.046 | |
| EGFLAM | CD44 | 0.046 | |
| GPC6 | AMPD2 | 0.045 | 0.026 |
| KLHL7 | EGFLAM | 0.042 | |
| MTNAP1 | GPC3 | 0.04 | |
| GPC6 | HADHB | 0.039 | 0.11 |
| GPC6 | KLHL7 | 0.038 | 0.078 |
| FGF1 | HADHA | 0.034 | 0.228 |
| GPC4 | DHRS2 | 0.032 | 0.09 |
| MPV17L2 | CD44 | 0.03 | 0.036 |
| HBEGF | HADHB | 0.03 | |
| HADHB | FGF1 | 0.024 | 0.07 |
| FGF4 | HADHB | 0.021 | |
| HBEGF | HADHA | 0.018 | |
| HADHA | ALK | 0.017 | |
| CD44 | OPN3 | 0.014 | |
| GPC4 | GMEB1 | 0.013 | |
| HADHB | ALK | 0.011 | |
| TMEFF1 | CD44 | 0.01 | |
| GPC4 | GMEB2 | 0.009 | 0.094 |
| HADHA | IRAK3 | 0.004 | 0.136 |
| GPC4 | PRDM10 | 0.003 | 0.088 |
| CEACAM7 | CD44 | 0.002 | 0.086 |
Related Complexes