hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13920.1
Complex Portal: CPX-14446
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RBMXL3 | RNA-binding motif protein, X-linked-like-3 | 2 | UniProt NCBI |
| GOLGA1 | Golgin subfamily A member 1 (Golgin-97) | 5 | UniProt NCBI |
| CNTRL | Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) | 5 | UniProt NCBI |
| ADAM18 | Disintegrin and metalloproteinase domain-containing protein 18 (ADAM 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III) (tMDC III) | 5 | UniProt NCBI |
| THG1L | Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (Induced in high glucose-1) (IHG-1) (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase) | 5 | UniProt NCBI |
| PACSIN3 | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) | 5 | UniProt NCBI |
| COBLL1 | Cordon-bleu protein-like 1 | 3 | UniProt NCBI |
| PACSIN2 | Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII) | 5 | UniProt NCBI |
| WDR27 | WD repeat-containing protein 27 | 3 | UniProt NCBI |
| PACSIN1 | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0097320 | 0.00936146543831 | 0.3 | PACSIN2 PACSIN3 PACSIN1 | plasma membrane tubulation |
| REAC:R-HSA-8856828 | 0.0208409907756 | 0.3 | PACSIN2 PACSIN3 PACSIN1 | Clathrin-mediated endocytosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PACSIN2 | PACSIN1 | 1.0 | 0.096 |
mutually_exclusive (Q9UKS6)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| PACSIN2 | COBLL1 | 1.0 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| PACSIN1 | COBLL1 | 1.0 | 0.148 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PACSIN3 | COBLL1 | 1.0 | 0.042 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PACSIN2 | PACSIN3 | 0.999 | 0.04 |
mutually_exclusive (Q9BY11)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| THG1L | PACSIN2 | 0.998 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PACSIN3 | PACSIN1 | 0.995 | 0.072 |
mutually_exclusive (Q9UNF0)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RBMXL3 | PACSIN3 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PACSIN3 | ADAM18 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PACSIN3 | CNTRL | 0.989 | 0.058 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ADAM18 | WDR27 | 0.961 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GOLGA1 | CNTRL | 0.954 | 0.146 | hein_WMM bioplex3_WMM WMM_only | |
| THG1L | COBLL1 | 0.939 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| THG1L | PACSIN3 | 0.921 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only | |
| CNTRL | ADAM18 | 0.904 | bioplex3_WMM WMM_only | ||
| RBMXL3 | ADAM18 | 0.902 | bioplex3_WMM WMM_only | ||
| RBMXL3 | CNTRL | 0.885 | bioplex3_WMM gupta_WMM WMM_only | ||
| PACSIN1 | CNTRL | 0.768 | 0.148 | bioplex3_WMM WMM_only | |
| COBLL1 | CNTRL | 0.715 | 0.064 | bioplex3_WMM WMM_only | |
| THG1L | PACSIN1 | 0.703 | 0.156 | bioplex3_WMM WMM_only | |
| RBMXL3 | PACSIN1 | 0.698 | bioplex3_WMM WMM_only | ||
| PACSIN1 | ADAM18 | 0.698 | bioplex3_WMM WMM_only | ||
| RBMXL3 | COBLL1 | 0.696 | bioplex3_WMM WMM_only | ||
| COBLL1 | ADAM18 | 0.696 | bioplex3_WMM WMM_only | ||
| PACSIN2 | CNTRL | 0.552 | 0.104 | bioplex3_WMM WMM_only | |
| PACSIN2 | RBMXL3 | 0.343 | bioplex3_WMM WMM_only | ||
| PACSIN2 | ADAM18 | 0.343 | bioplex3_WMM WMM_only |
Related Complexes