hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13924.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CWC27 | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | 5 | UniProt NCBI |
| AFF3 | AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) | 5 | UniProt NCBI |
| TRMT10A | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) | 5 | UniProt NCBI |
| SYT2 | Synaptotagmin-2 (Synaptotagmin II) (SytII) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0000347 | 0.00359604599989 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Micrognathia |
| HP:0009118 | 0.00363591871216 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Aplasia/Hypoplasia of the mandible |
| HP:0009116 | 0.00381946424586 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Aplasia/Hypoplasia involving bones of the skull |
| HP:0009122 | 0.00580091998995 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Aplasia/hypoplasia affecting bones of the axial skeleton |
| HP:0001317 | 0.00795240650999 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal cerebellum morphology |
| HP:0011283 | 0.00809740415548 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal metencephalon morphology |
| HP:0011282 | 0.00809740415548 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal hindbrain morphology |
| HP:0005943 | 0.0092117244708 | 0.5 | SYT2 AFF3 | Respiratory arrest |
| HP:0000277 | 0.0110624796474 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal mandible morphology |
| HP:0030791 | 0.0135549517328 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal jaw morphology |
| HP:0009115 | 0.0155944083765 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Aplasia/hypoplasia involving the skeleton |
| HP:0000377 | 0.0200647502126 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal pinna morphology |
| HP:0000356 | 0.0209437713541 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormality of the outer ear |
| HP:0001763 | 0.0217270761582 | 0.75 | CWC27 AFF3 SYT2 | Pes planus |
| HP:0011821 | 0.0242493726833 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal facial skeleton morphology |
| HP:0001620 | 0.0273256954732 | 0.5 | SYT2 TRMT10A | High pitched voice |
| HP:0011297 | 0.0360876399144 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal digit morphology |
| HP:0001760 | 0.0361997133303 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal foot morphology |
| HPA:0320893 | 0.0394949882091 | 0.5 | CWC27 AFF3 | nasopharynx; goblet cells[High] |
| HP:5200005 | 0.0458701548093 | 0.5 | SYT2 TRMT10A | Abnormal pitch |
| HP:0031703 | 0.0490742875352 | 1.0 | CWC27 AFF3 SYT2 TRMT10A | Abnormal ear morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRMT10A | SYT2 | 0.971 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CWC27 | SYT2 | 0.959 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AFF3 | SYT2 | 0.954 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| AFF3 | TRMT10A | 0.415 | bioplex3_WMM WMM_only | |
| CWC27 | AFF3 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only | |
| CWC27 | TRMT10A | 0.087 | 0.094 | bioplex3_WMM WMM_only |
Related Complexes