hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13926.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| REXO5 | RNA exonuclease 5 (EC 3.1.-.-) (Exonuclease NEF-sp) | 3 | UniProt NCBI |
| GTPBP6 | Putative GTP-binding protein 6 (Pseudoautosomal GTP-binding protein-like) | 3 | UniProt NCBI |
| TRMT10C | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | 5 | UniProt NCBI |
| MRM1 | rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1145)-2'-O)-methyltransferase) (16S rRNA [Gm1145] 2'-O-methyltransferase) | 5 | UniProt NCBI |
| DECR1 | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1) | 5 | UniProt NCBI |
| PTTG1 | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | 5 | UniProt NCBI |
| HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8868766 | 8.4720413934e-07 | 0.5 | HSD17B10 TRMT10C MRM1 | rRNA processing in the mitochondrion |
| CORUM:7429 | 1.70876175213e-05 | 0.333333333333 | HSD17B10 TRMT10C | HSD17B10-TRMT10C complex |
| CORUM:7428 | 5.12534978153e-05 | 0.333333333333 | HSD17B10 TRMT10C | mtRNase P |
| REAC:R-HSA-6785470 | 0.00025805759528 | 0.333333333333 | HSD17B10 TRMT10C | tRNA processing in the mitochondrion |
| WP:WP5241 | 0.000362274856058 | 0.333333333333 | HSD17B10 DECR1 | Mitochondrial beta oxidation |
| REAC:R-HSA-6787450 | 0.000722165722116 | 0.333333333333 | HSD17B10 TRMT10C | tRNA modification in the mitochondrion |
| REAC:R-HSA-72312 | 0.00900407624294 | 0.5 | HSD17B10 TRMT10C MRM1 | rRNA processing |
| GO:0030678 | 0.0210651876021 | 0.333333333333 | HSD17B10 TRMT10C | mitochondrial ribonuclease P complex |
| GO:0097745 | 0.0210651876021 | 0.333333333333 | HSD17B10 TRMT10C | mitochondrial tRNA 5'-end processing |
| GO:0000964 | 0.042122686785 | 0.333333333333 | HSD17B10 TRMT10C | mitochondrial RNA 5'-end processing |
| GO:0070901 | 0.042122686785 | 0.333333333333 | HSD17B10 TRMT10C | mitochondrial tRNA methylation |
| GO:1990180 | 0.042122686785 | 0.333333333333 | HSD17B10 TRMT10C | mitochondrial tRNA 3'-end processing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRMT10C | HSD17B10 | 0.998 | 0.182 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM |
| DECR1 | MRM1 | 0.995 | 0.302 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| HSD17B10 | MRM1 | 0.985 | 0.074 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GTPBP6 | TRMT10C | 0.973 | 0.248 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM |
| TRMT10C | MRM1 | 0.971 | 0.488 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GTPBP6 | MRM1 | 0.963 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| TRMT10C | DECR1 | 0.962 | 0.106 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| GTPBP6 | DECR1 | 0.945 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| GTPBP6 | HSD17B10 | 0.941 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM |
| DECR1 | PTTG1 | 0.936 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DECR1 | HSD17B10 | 0.884 | 0.352 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| GTPBP6 | REXO5 | 0.864 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only |
| TRMT10C | REXO5 | 0.137 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only |
| DECR1 | REXO5 | 0.016 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only |
| HSD17B10 | PTTG1 | 0.003 | 0.094 | bioplex3_HEK293 bioplex () |
| HSD17B10 | REXO5 | 0.003 | 0.094 | bioplex3_WMM WMM_only |
Related Complexes