hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13929.1
Complex Portal: CPX-13819
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POTEJ | POTE ankyrin domain family member J | 4 | UniProt NCBI |
| PFN3 | Profilin-3 (Profilin III) | 3 | UniProt NCBI |
| UBC | Polyubiquitin-C [Cleaved into: Ubiquitin] | 5 | UniProt NCBI |
| MRTFA | Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) | 5 | UniProt NCBI |
| BCL7C | B-cell CLL/lymphoma 7 protein family member C | 4 | UniProt NCBI |
| SPIRE2 | Protein spire homolog 2 (Spir-2) | 5 | UniProt NCBI |
| CAP2 | Adenylyl cyclase-associated protein 2 (CAP 2) | 5 | UniProt NCBI |
| PHACTR2 | Phosphatase and actin regulator 2 | 5 | UniProt NCBI |
| CAP1 | Adenylyl cyclase-associated protein 1 (CAP 1) | 5 | UniProt NCBI |
| SPIRE1 | Protein spire homolog 1 (Spir-1) | 5 | UniProt NCBI |
| BCL7A | B-cell CLL/lymphoma 7 protein family member A | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030036 | 0.00116834685417 | 0.636363636364 | PHACTR2 PFN3 MRTFA SPIRE1 CAP1 CAP2 SPIRE2 | actin cytoskeleton organization |
| GO:0030029 | 0.00247394956809 | 0.636363636364 | PHACTR2 PFN3 MRTFA SPIRE1 CAP1 CAP2 SPIRE2 | actin filament-based process |
| REAC:R-HSA-428890 | 0.00372670794354 | 0.181818181818 | CAP1 CAP2 | Role of ABL in ROBO-SLIT signaling |
| GO:2000781 | 0.0120389546625 | 0.363636363636 | SPIRE1 BCL7A BCL7C SPIRE2 | positive regulation of double-strand break repair |
| GO:0003779 | 0.0487625050341 | 0.454545454545 | CAP2 PHACTR2 CAP1 PFN3 MRTFA | actin binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAP2 | CAP1 | 1.0 | 0.416 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| PFN3 | POTEJ | 0.996 | 0.082 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BCL7C | PHACTR2 | 0.995 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CAP2 | UBC | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CAP1 | BCL7C | 0.993 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BCL7A | PHACTR2 | 0.992 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BCL7A | POTEJ | 0.99 | 0.028 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BCL7A | BCL7C | 0.99 | 0.136 |
mutually_exclusive (Q92784)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CAP2 | BCL7C | 0.986 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPIRE2 | BCL7A | 0.985 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CAP2 | BCL7A | 0.969 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MRTFA | BCL7A | 0.969 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BCL7C | SPIRE1 | 0.964 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CAP2 | POTEJ | 0.955 | 0.026 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAP1 | BCL7A | 0.951 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BCL7A | SPIRE1 | 0.933 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UBC | POTEJ | 0.902 | bioplex3_WMM WMM_only | ||
| SPIRE2 | BCL7C | 0.873 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| SPIRE2 | SPIRE1 | 0.781 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| CAP1 | UBC | 0.591 | bioplex3_WMM WMM_only boldt_WMM | ||
| CAP2 | SPIRE1 | 0.559 | 0.03 | bioplex_WMM bioplex3_WMM WMM_only | |
| CAP2 | SPIRE2 | 0.527 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PHACTR2 | SPIRE1 | 0.511 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only | |
| CAP1 | POTEJ | 0.46 | 0.044 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| MRTFA | BCL7C | 0.349 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| POTEJ | PHACTR2 | 0.333 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPIRE2 | PHACTR2 | 0.306 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CAP1 | SPIRE2 | 0.29 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CAP1 | SPIRE1 | 0.245 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| MRTFA | PHACTR2 | 0.216 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| CAP1 | PHACTR2 | 0.209 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | |
| CAP2 | PHACTR2 | 0.202 | 0.144 | bioplex_WMM bioplex3_WMM WMM_only | |
| BCL7C | POTEJ | 0.188 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| POTEJ | SPIRE1 | 0.172 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPIRE2 | POTEJ | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MRTFA | SPIRE1 | 0.164 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| MRTFA | SPIRE2 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CAP2 | MRTFA | 0.164 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only | |
| MRTFA | POTEJ | 0.164 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| CAP1 | MRTFA | 0.067 | 0.046 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| CAP1 | PFN3 | 0.003 | 0.402 | bioplex3_HCT116 WMM_only |
Related Complexes