hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13943.1
Complex Portal: CPX-22011
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLIN5 | Perilipin-5 (Lipid storage droplet protein 5) | 5 | UniProt NCBI |
| CASP8 | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | 5 | UniProt NCBI |
| CFLAR | CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5798 | 1.02521027753e-05 | 0.666666666667 | CFLAR CASP8 | Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced |
| CORUM:5799 | 1.02521027753e-05 | 0.666666666667 | CFLAR CASP8 | DISC complex (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced |
| CORUM:5749 | 1.02521027753e-05 | 0.666666666667 | CFLAR CASP8 | MRIT complex |
| REAC:R-HSA-75158 | 0.000143154936711 | 0.666666666667 | CFLAR CASP8 | TRAIL signaling |
| WP:WP2507 | 0.000193548942551 | 0.666666666667 | CFLAR CASP8 | Nanomaterial induced apoptosis |
| WP:WP314 | 0.00079501095268 | 0.666666666667 | CFLAR CASP8 | Fas ligand pathway and stress induction of heat shock proteins |
| WP:WP4754 | 0.00155728900053 | 0.666666666667 | CFLAR CASP8 | IL 18 signaling pathway |
| KEGG:05142 | 0.00291071815858 | 0.666666666667 | CFLAR CASP8 | Chagas disease |
| WP:WP254 | 0.00296720799434 | 0.666666666667 | CFLAR CASP8 | Apoptosis |
| WP:WP1772 | 0.00338983502479 | 0.666666666667 | CFLAR CASP8 | Apoptosis modulation and signaling |
| KEGG:04668 | 0.00339398898617 | 0.666666666667 | CFLAR CASP8 | TNF signaling pathway |
| WP:WP231 | 0.0039339723602 | 0.666666666667 | CFLAR CASP8 | TNF alpha signaling pathway |
| KEGG:04210 | 0.00542112539104 | 0.666666666667 | CFLAR CASP8 | Apoptosis |
| KEGG:05160 | 0.00646184763568 | 0.666666666667 | CFLAR CASP8 | Hepatitis C |
| KEGG:04217 | 0.00706776241177 | 0.666666666667 | CFLAR CASP8 | Necroptosis |
| GO:0097342 | 0.0140440992017 | 0.666666666667 | CFLAR CASP8 | ripoptosome |
| CORUM:1062 | 0.0249718442456 | 0.333333333333 | CASP8 | BAR-BCL2-CASP8 complex |
| GO:0031264 | 0.0294899169624 | 0.666666666667 | CFLAR CASP8 | death-inducing signaling complex |
| CORUM:5860 | 0.0499402709677 | 0.333333333333 | CASP8 | DISC complex (FAS, FADD, CASP8) |
| CORUM:5808 | 0.0499402709677 | 0.333333333333 | CASP8 | DISC complex (CD95, FADD, CASP8) |
| CORUM:5800 | 0.0499402709677 | 0.333333333333 | CASP8 | DISC complex (FAS, FADD, CASP8) |
| CORUM:5473 | 0.0499402709677 | 0.333333333333 | CASP8 | DISC complex (FAS, FADD, CASP8) |
| CORUM:5991 | 0.0499402709677 | 0.333333333333 | CASP8 | LRRK2-FADD-CASP8 complex |
| CORUM:5859 | 0.0499402709677 | 0.333333333333 | CASP8 | FAS-FADD-CASP8-CASP10 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CASP8 | CFLAR | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PLIN5 | CFLAR | 0.84 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PLIN5 | CASP8 | 0.224 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes