hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13949.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| APOOL | MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A) | 5 | UniProt NCBI |
| TRAK1 | Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton) | 5 | UniProt NCBI |
| SAMM50 | Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3) | 5 | UniProt NCBI |
| GPR3 | G-protein coupled receptor 3 (ACCA orphan receptor) | 5 | UniProt NCBI |
| CARD19 | Caspase recruitment domain-containing protein 19 (Bcl10-interacting CARD protein) (BinCARD) | 5 | UniProt NCBI |
| CD244 | Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244) | 5 | UniProt NCBI |
| MTX3 | Metaxin-3 | 4 | UniProt NCBI |
| MTX2 | Metaxin-2 (Mitochondrial outer membrane import complex protein 2) | 5 | UniProt NCBI |
| TSPOAP1 | Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) | 5 | UniProt NCBI |
| CRACR2B | EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated calcium channel regulator 2B) (CRAC channel regulator 2B) (Calcium release-activated channel regulator 2B) | 5 | UniProt NCBI |
| FAM3B | Protein FAM3B (Cytokine-like protein 2-21) (Pancreatic-derived factor) (PANDER) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6249 | 2.52020279376e-06 | 0.272727272727 | APOOL SAMM50 MTX2 | MIB complex |
| GO:0001401 | 4.28500508143e-06 | 0.363636363636 | APOOL MTX2 SAMM50 MTX3 | SAM complex |
| GO:0140275 | 4.28500508143e-06 | 0.363636363636 | APOOL MTX2 SAMM50 MTX3 | MIB complex |
| GO:0005742 | 4.18126230382e-05 | 0.363636363636 | APOOL MTX2 SAMM50 MTX3 | mitochondrial outer membrane translocase complex |
| GO:0098799 | 5.16310778922e-05 | 0.363636363636 | APOOL MTX2 SAMM50 MTX3 | outer mitochondrial membrane protein complex |
| REAC:R-HSA-8949613 | 0.000329950651236 | 0.272727272727 | APOOL SAMM50 MTX2 | Cristae formation |
| GO:0007007 | 0.000782670774929 | 0.363636363636 | APOOL MTX2 SAMM50 MTX3 | inner mitochondrial membrane organization |
| KEGG:04137 | 0.00236472198897 | 0.272727272727 | MTX3 SAMM50 MTX2 | Mitophagy - animal |
| REAC:R-HSA-1592230 | 0.00812764950682 | 0.272727272727 | APOOL SAMM50 MTX2 | Mitochondrial biogenesis |
| GO:0007006 | 0.017043142227 | 0.363636363636 | APOOL MTX2 SAMM50 MTX3 | mitochondrial membrane organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SAMM50 | MTX2 | 1.0 | 0.958 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| MTX2 | CARD19 | 1.0 | 0.27 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| TRAK1 | CARD19 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MTX3 | MTX2 | 0.998 | 0.32 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| SAMM50 | CARD19 | 0.998 | 0.26 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MTX2 | CD244 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRAK1 | SAMM50 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MTX3 | CARD19 | 0.995 | 0.116 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CD244 | TSPOAP1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CARD19 | CD244 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SAMM50 | MTX3 | 0.985 | 0.404 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| TRAK1 | MTX2 | 0.982 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| APOOL | CARD19 | 0.978 | 0.196 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| CRACR2B | CARD19 | 0.971 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SAMM50 | CD244 | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MTX3 | APOOL | 0.95 | 0.104 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| SAMM50 | APOOL | 0.948 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| MTX2 | APOOL | 0.948 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| MTX3 | CD244 | 0.947 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SAMM50 | FAM3B | 0.933 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MTX2 | FAM3B | 0.922 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GPR3 | SAMM50 | 0.88 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRAK1 | MTX3 | 0.855 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CARD19 | FAM3B | 0.791 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TRAK1 | APOOL | 0.41 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CARD19 | TSPOAP1 | 0.377 | bioplex_WMM bioplex3_WMM WMM_only | |
| MTX3 | TSPOAP1 | 0.17 | bioplex_WMM bioplex3_WMM WMM_only | |
| MTX2 | TSPOAP1 | 0.147 | bioplex_WMM bioplex3_WMM WMM_only | |
| SAMM50 | TSPOAP1 | 0.135 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPR3 | MTX2 | 0.035 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MTX3 | FAM3B | 0.033 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes