hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13970.1

Complex Portal: CPX-13972

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
ACAA1	3-ketoacyl-CoA thiolase, peroxisomal (EC 2.3.1.16) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Acetyl-CoA acyltransferase) (EC 2.3.1.9) (Beta-ketothiolase) (Peroxisomal 3-oxoacyl-CoA thiolase)	5	UniProt NCBI
PEX7	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7)	5	UniProt NCBI
NANOS1	Nanos homolog 1 (NOS-1) (EC_Rep1a)	5	UniProt NCBI
PEX14	Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)	5	UniProt NCBI
PHYH	Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)	5	UniProt NCBI
PEX13	Peroxisomal membrane protein PEX13 (Peroxin-13)	5	UniProt NCBI
SPX	Spexin (NPQ) (Neuropeptide Q) (Spexin hormone) [Cleaved into: Spexin-1; Spexin-2 (NPQ 53-70)]	5	UniProt NCBI
C6orf226	Uncharacterized protein C6orf226	2	UniProt NCBI
PEX5	Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04146	2.33082662803e-11	0.666666666667	PHYH PEX5 PEX13 PEX14 ACAA1 PEX7	Peroxisome
HP:0010571	4.12129977045e-11	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Elevated circulating phytanic acid concentration
HP:0010965	4.12129977045e-11	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal circulating phytanic acid concentration
HP:0010964	8.98782211458e-11	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal circulating long-chain fatty-acid concentration
REAC:R-HSA-9033241	9.11711510274e-09	0.555555555556	ACAA1 PEX13 PHYH PEX14 PEX7	Peroxisomal protein import
HP:0004359	4.32592964799e-08	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal circulating fatty-acid concentration
GO:0005777	5.20622699023e-07	0.666666666667	PHYH PEX5 PEX13 PEX14 ACAA1 PEX7	peroxisome
GO:0042579	5.20622699023e-07	0.666666666667	PHYH PEX5 PEX13 PEX14 ACAA1 PEX7	microbody
GO:0016558	1.09198397762e-06	0.444444444444	PEX5 PEX7 PEX14 PEX13	protein import into peroxisome matrix
REAC:R-HSA-9609507	1.87818464505e-06	0.555555555556	ACAA1 PEX13 PHYH PEX14 PEX7	Protein localization
HP:0010655	2.15109821769e-06	0.444444444444	PEX5 PEX7 PEX14 PEX13	Epiphyseal stippling
HP:0008064	4.16300344157e-06	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Ichthyosis
GO:0072663	6.01421448879e-06	0.444444444444	PEX5 PEX7 PEX14 PEX13	establishment of protein localization to peroxisome
GO:0072662	6.01421448879e-06	0.444444444444	PEX5 PEX7 PEX14 PEX13	protein localization to peroxisome
GO:0015919	7.86258774297e-06	0.444444444444	PEX5 PEX7 PEX14 PEX13	peroxisomal membrane transport
GO:0043574	7.86258774297e-06	0.444444444444	PEX5 PEX7 PEX14 PEX13	peroxisomal transport
GO:0016560	8.07408345042e-06	0.333333333333	PEX13 PEX14 PEX5	protein import into peroxisome matrix, docking
HP:0002652	1.53317745668e-05	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Skeletal dysplasia
GO:0065002	1.97504384826e-05	0.444444444444	PEX5 PEX7 PEX14 PEX13	intracellular protein transmembrane transport
HP:0000662	2.71193406312e-05	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Nyctalopia
HP:0010656	3.09695828733e-05	0.444444444444	PEX5 PEX7 PEX14 PEX13	Abnormal epiphyseal ossification
HP:0001088	3.22069162042e-05	0.333333333333	PEX13 PEX14 PEX5	Brushfield spots
GO:0016561	3.22863876272e-05	0.333333333333	PEX13 PEX14 PEX5	protein import into peroxisome matrix, translocation
HP:0000510	3.66911672251e-05	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Rod-cone dystrophy
HP:0008167	6.6548215792e-05	0.333333333333	PEX13 PEX14 PEX5	Very long chain fatty acid accumulation
GO:0007031	9.02134234826e-05	0.444444444444	PEX5 PEX7 PEX14 PEX13	peroxisome organization
HP:0005930	0.000105014793021	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal epiphysis morphology
GO:0044743	0.000134592174076	0.444444444444	PEX5 PEX7 PEX14 PEX13	protein transmembrane import into intracellular organelle
HP:0003119	0.000174908616442	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal circulating lipid concentration
HP:0012368	0.000187171586078	0.444444444444	PEX5 PEX7 PEX14 PEX13	Flat face
HP:0007703	0.000236239933639	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormality of retinal pigmentation
GO:0005782	0.000300019348538	0.444444444444	PEX5 ACAA1 PHYH PEX7	peroxisomal matrix
GO:0031907	0.000300019348538	0.444444444444	PEX5 ACAA1 PHYH PEX7	microbody lumen
HP:4000163	0.000306458653145	0.222222222222	PEX7 PHYH	Reduced phytanic acid oxidase activity in cultured fibroblasts
HP:0000556	0.000347245815252	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Retinal dystrophy
HP:0001133	0.00035056813921	0.444444444444	PEX5 PEX7 PEX14 PEX13	Constriction of peripheral visual field
HP:0003336	0.00040422919398	0.444444444444	PEX5 PEX7 PEX14 PEX13	Abnormal enchondral ossification
GO:0071806	0.000445161055123	0.444444444444	PEX5 PEX7 PEX14 PEX13	protein transmembrane transport
HP:0011368	0.000511897093436	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Epidermal thickening
GO:0031903	0.000534830416832	0.444444444444	PEX5 PEX7 PEX14 PEX13	microbody membrane
GO:0005778	0.000534830416832	0.444444444444	PEX5 PEX7 PEX14 PEX13	peroxisomal membrane
HP:0001072	0.000931475207695	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Thickened skin
HP:0002376	0.0010245054825	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Developmental regression
REAC:R-HSA-9033500	0.0011967088847	0.222222222222	ACAA1 PHYH	TYSND1 cleaves peroxisomal proteins
HP:0011675	0.00204050421827	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Arrhythmia
HP:0008207	0.00219910586189	0.333333333333	PEX13 PEX14 PEX5	Primary adrenal insufficiency
HP:0009891	0.00234832040817	0.333333333333	PEX13 PEX14 PEX5	Underdeveloped supraorbital ridges
HP:0000474	0.00266659082239	0.333333333333	PEX13 PEX14 PEX5	Thickened nuchal skin fold
HP:0005469	0.00283592373541	0.333333333333	PEX13 PEX14 PEX5	Flat occiput
HP:0010766	0.00314094119915	0.444444444444	PEX5 PEX7 PEX14 PEX13	Ectopic calcification
HP:0030956	0.00315211485752	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormality of cardiovascular system electrophysiology
HP:0008048	0.00338637189189	0.333333333333	PEX13 PEX14 PEX5	Abnormal line of Schwalbe morphology
HP:0000627	0.00338637189189	0.333333333333	PEX13 PEX14 PEX5	Posterior embryotoxon
HP:0007598	0.00379009050824	0.333333333333	PEX13 PEX14 PEX5	Bilateral single transverse palmar creases
HP:0001638	0.00412674402144	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Cardiomyopathy
HP:0008665	0.0044535476722	0.333333333333	PEX13 PEX14 PEX5	Clitoral hypertrophy
HP:0040253	0.0044535476722	0.333333333333	PEX13 PEX14 PEX5	Increased size of the clitoris
HP:0040252	0.0044535476722	0.333333333333	PEX13 PEX14 PEX5	Abnormal size of the clitoris
HP:0001315	0.0049787468855	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Reduced tendon reflexes
HP:0001637	0.00517462691203	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal myocardium morphology
HP:0012736	0.00518974778476	0.333333333333	PEX13 PEX14 PEX5	Profound global developmental delay
HP:0006829	0.00518974778476	0.333333333333	PEX13 PEX14 PEX5	Severe muscular hypotonia
HP:0003323	0.00629087234375	0.333333333333	PEX13 PEX14 PEX5	Progressive muscle weakness
HP:0002093	0.00690792985577	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Respiratory insufficiency
HP:0001123	0.00786951147212	0.444444444444	PEX5 PEX7 PEX14 PEX13	Visual field defect
HP:0002654	0.00856441317229	0.222222222222	PEX7 PHYH	Multiple epiphyseal dysplasia
REAC:R-HSA-9603798	0.00954313848115	0.222222222222	PEX13 PEX14	Class I peroxisomal membrane protein import
HP:0008572	0.00969509588682	0.333333333333	PEX13 PEX14 PEX5	External ear malformation
HP:0000846	0.0100904083719	0.333333333333	PEX13 PEX14 PEX5	Adrenal insufficiency
HP:0000260	0.0113399794078	0.333333333333	PEX13 PEX14 PEX5	Wide anterior fontanel
HP:0000056	0.0113399794078	0.333333333333	PEX13 PEX14 PEX5	Abnormal clitoris morphology
HP:0000003	0.0131595281858	0.333333333333	PEX13 PEX14 PEX5	Multicystic kidney dysplasia
HP:0003271	0.0138636848354	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Visceromegaly
HP:0000582	0.0150151918753	0.444444444444	PEX5 PEX7 PEX14 PEX13	Upslanted palpebral fissure
REAC:R-HSA-390918	0.0150906736209	0.222222222222	ACAA1 PHYH	Peroxisomal lipid metabolism
HP:0011314	0.0161641710341	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal long bone morphology
HP:0100538	0.0173565762481	0.333333333333	PEX13 PEX14 PEX5	Abnormality of the supraorbital ridges
HP:0000508	0.0176822244117	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Ptosis
HP:0002021	0.0179360873502	0.333333333333	PEX13 PEX14 PEX5	Pyloric stenosis
HP:0004400	0.0197509435844	0.333333333333	PEX13 PEX14 PEX5	Abnormality of the pylorus
HP:0025667	0.0210257565099	0.333333333333	PEX13 PEX14 PEX5	Fetal neck anomaly
HP:0001438	0.0210539673805	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal abdomen morphology
HP:0011217	0.0216830266118	0.333333333333	PEX13 PEX14 PEX5	Abnormal shape of the occiput
HP:0012294	0.0230379440806	0.333333333333	PEX13 PEX14 PEX5	Abnormal occipital bone morphology
HP:0004689	0.0238199336716	0.222222222222	PEX7 PHYH	Short fourth metatarsal
HP:0040035	0.0238199336716	0.222222222222	PEX7 PHYH	Abnormality of the fourth metatarsal bone
HP:0000518	0.0240656433098	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Cataract
HP:0011425	0.0251732083318	0.333333333333	PEX13 PEX14 PEX5	Fetal ultrasound soft marker
HP:0011733	0.0251732083318	0.333333333333	PEX13 PEX14 PEX5	Abnormality of adrenal physiology
HP:0000517	0.0272215457442	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal lens morphology
HP:4000195	0.0277810467869	0.222222222222	PEX7 PHYH	Abnormal enzyme activity in cultured fibroblasts
HP:0000236	0.0282177129725	0.333333333333	PEX13 PEX14 PEX5	Abnormality of the anterior fontanelle
HP:0000407	0.0389196706787	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Sensorineural hearing impairment
HP:0008034	0.0407639834225	0.333333333333	PEX13 PEX14 PEX5	Abnormal iris pigmentation
HP:0000055	0.0471022227504	0.333333333333	PEX13 PEX14 PEX5	Abnormal female external genitalia morphology
HP:0000479	0.0499556143705	0.555555555556	PEX5 PEX7 PEX13 PEX14 PHYH	Abnormal retinal morphology
CORUM:1984	0.0499842271994	0.111111111111	PEX14	PEX14 homodimer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
C6orf226	PEX7	1.0		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PHYH	C6orf226	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
C6orf226	ACAA1	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PEX7	PEX13	0.998		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ACAA1	PEX7	0.998		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PHYH	PEX7	0.996			bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
PHYH	PEX5	0.967			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
PEX14	PHYH	0.961	0.082	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
NANOS1	PHYH	0.953		structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM WMM_only
C6orf226	PEX13	0.921		mutually_exclusive (O00628)	bioplex_WMM bioplex3_WMM WMM_only
PEX5	ACAA1	0.916		mutually_exclusive (O00628)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ACAA1	SPX	0.912			bioplex3_HEK293 bioplex3_WMM WMM_only
PEX14	PEX5	0.871			bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
PEX5	C6orf226	0.841			bioplex_WMM bioplex3_WMM WMM_only
PEX5	PEX7	0.77		structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM WMM_only
PEX14	PEX7	0.612			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PEX14	ACAA1	0.371	0.124		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PEX14	C6orf226	0.269			bioplex_WMM bioplex3_WMM WMM_only
PHYH	ACAA1	0.164	0.144		bioplex_WMM bioplex3_WMM WMM_only
ACAA1	PEX13	0.027	0.11		bioplex3_WMM WMM_only
PEX14	NANOS1	0.022		mutually_exclusive (O14832)	bioplex3_HEK293 bioplex3_WMM WMM_only
PEX14	PEX13	0.01	0.092		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
ACAA1	huMAP3_02037.1 huMAP3_02891.1 huMAP3_06264.1 huMAP3_06481.1 huMAP3_11110.1 huMAP3_12934.1 huMAP3_13239.1 huMAP3_13970.1 huMAP3_14348.1 huMAP3_15138.1
PEX7	huMAP3_04808.1 huMAP3_06481.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_11110.1 huMAP3_12934.1 huMAP3_13239.1 huMAP3_13970.1 huMAP3_14584.1 huMAP3_15138.1
NANOS1	huMAP3_00933.1 huMAP3_06513.1 huMAP3_06662.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10924.1 huMAP3_11777.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13239.1 huMAP3_13970.1 huMAP3_14335.1 huMAP3_15138.1
PEX14	huMAP3_00933.1 huMAP3_00974.1 huMAP3_01324.1 huMAP3_06662.1 huMAP3_06754.1 huMAP3_07035.1 huMAP3_08245.1 huMAP3_08472.1 huMAP3_09426.1 huMAP3_10924.1 huMAP3_11777.1 huMAP3_13970.1
PHYH	huMAP3_00933.1 huMAP3_06513.1 huMAP3_06662.1 huMAP3_10924.1 huMAP3_11777.1 huMAP3_13239.1 huMAP3_13970.1 huMAP3_14335.1 huMAP3_15138.1
PEX13	huMAP3_04808.1 huMAP3_06481.1 huMAP3_09191.1 huMAP3_10656.1 huMAP3_11110.1 huMAP3_11230.1 huMAP3_12934.1 huMAP3_13178.1 huMAP3_13239.1 huMAP3_13970.1 huMAP3_15138.1
SPX	huMAP3_03590.1 huMAP3_09172.1 huMAP3_09772.1 huMAP3_10918.1 huMAP3_11260.1 huMAP3_11298.1 huMAP3_11373.1 huMAP3_12920.1 huMAP3_12934.1 huMAP3_13801.1 huMAP3_13970.1 huMAP3_14430.1 huMAP3_14931.1 huMAP3_15138.1
C6orf226	huMAP3_01976.1 huMAP3_02891.1 huMAP3_10924.1 huMAP3_11110.1 huMAP3_12934.1 huMAP3_13239.1 huMAP3_13970.1 huMAP3_15138.1
PEX5	huMAP3_00933.1 huMAP3_06513.1 huMAP3_10924.1 huMAP3_11777.1 huMAP3_13970.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13970.1

Complex Portal: CPX-13972