hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13976.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) | 5 | UniProt NCBI |
| GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) | 5 | UniProt NCBI |
| GLRA3 | Glycine receptor subunit alpha-3 | 5 | UniProt NCBI |
| GCNT3 | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (hC2GnT-M) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase) (C2/4GnT) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0099095 | 8.45465618902e-05 | 0.75 | GABRB3 GABRB2 GLRA3 | ligand-gated monoatomic anion channel activity |
| KEGG:04080 | 0.000364678239794 | 0.75 | GABRB3 GABRB2 GLRA3 | Neuroactive ligand-receptor interaction |
| KEGG:05033 | 0.00069087933531 | 0.5 | GABRB3 GABRB2 | Nicotine addiction |
| WP:WP4159 | 0.00070344077777 | 0.5 | GABRB3 GABRB2 | GABA receptor signaling |
| REAC:R-HSA-112314 | 0.000897810107574 | 0.75 | GABRB3 GABRB2 GLRA3 | Neurotransmitter receptors and postsynaptic signal transmission |
| WP:WP4829 | 0.00103429913449 | 0.5 | GABRB3 GABRB2 | mBDNF and proBDNF regulation of GABA neurotransmission |
| REAC:R-HSA-112315 | 0.00190780632503 | 0.75 | GABRB3 GABRB2 GLRA3 | Transmission across Chemical Synapses |
| GO:1902476 | 0.0025122894873 | 0.75 | GABRB3 GABRB2 GLRA3 | chloride transmembrane transport |
| GO:0022824 | 0.0037914498893 | 0.75 | GABRB3 GABRB2 GLRA3 | transmitter-gated monoatomic ion channel activity |
| GO:0022835 | 0.0037914498893 | 0.75 | GABRB3 GABRB2 GLRA3 | transmitter-gated channel activity |
| GO:0005230 | 0.00544401218013 | 0.75 | GABRB3 GABRB2 GLRA3 | extracellular ligand-gated monoatomic ion channel activity |
| GO:0005254 | 0.00544401218013 | 0.75 | GABRB3 GABRB2 GLRA3 | chloride channel activity |
| GO:0098656 | 0.00544401218013 | 0.75 | GABRB3 GABRB2 GLRA3 | monoatomic anion transmembrane transport |
| KEGG:04727 | 0.00551283411821 | 0.5 | GABRB3 GABRB2 | GABAergic synapse |
| KEGG:05032 | 0.0056793701001 | 0.5 | GABRB3 GABRB2 | Morphine addiction |
| GO:0098661 | 0.00582352741409 | 0.75 | GABRB3 GABRB2 GLRA3 | inorganic anion transmembrane transport |
| REAC:R-HSA-112316 | 0.00603406960129 | 0.75 | GABRB3 GABRB2 GLRA3 | Neuronal System |
| GO:0030594 | 0.0079870728422 | 0.75 | GABRB3 GABRB2 GLRA3 | neurotransmitter receptor activity |
| REAC:R-HSA-977443 | 0.00837722051003 | 0.5 | GABRB3 GABRB2 | GABA receptor activation |
| KEGG:04726 | 0.00867836513934 | 0.5 | GABRB3 GABRB2 | Serotonergic synapse |
| REAC:R-HSA-1236394 | 0.00922347264132 | 0.5 | GABRB3 GABRB2 | Signaling by ERBB4 |
| GO:0006821 | 0.00951168180783 | 0.75 | GABRB3 GABRB2 GLRA3 | chloride transport |
| GO:0005253 | 0.0106287970558 | 0.75 | GABRB3 GABRB2 GLRA3 | monoatomic anion channel activity |
| KEGG:04723 | 0.017422762868 | 0.5 | GABRB3 GABRB2 | Retrograde endocannabinoid signaling |
| GO:0015108 | 0.0175369202004 | 0.75 | GABRB3 GABRB2 GLRA3 | chloride transmembrane transporter activity |
| GO:0006820 | 0.0248327141789 | 0.75 | GABRB3 GABRB2 GLRA3 | monoatomic anion transport |
| GO:0015698 | 0.0258660780327 | 0.75 | GABRB3 GABRB2 GLRA3 | inorganic anion transport |
| GO:0071420 | 0.0280843539964 | 0.5 | GABRB3 GABRB2 | cellular response to histamine |
| GO:0008509 | 0.0326725154884 | 0.75 | GABRB3 GABRB2 GLRA3 | monoatomic anion transmembrane transporter activity |
| GO:0015103 | 0.0378152735667 | 0.75 | GABRB3 GABRB2 GLRA3 | inorganic anion transmembrane transporter activity |
| CORUM:5809 | 0.049938562206 | 0.25 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRG2) |
| CORUM:7461 | 0.049938562206 | 0.25 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRG2) |
| CORUM:7462 | 0.049938562206 | 0.25 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRD) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GABRB2 | GABRB3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GLRA3 | GCNT3 | 0.967 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GLRA3 | GABRB3 | 0.938 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GCNT3 | GABRB3 | 0.25 | bioplex3_WMM WMM_only |
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