hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13984.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GATA2 | Endothelial transcription factor GATA-2 (GATA-binding protein 2) | 5 | UniProt NCBI |
| SKI | Ski oncogene (Proto-oncogene c-Ski) | 5 | UniProt NCBI |
| MPND | MPN domain-containing protein (EC 3.4.-.-) | 5 | UniProt NCBI |
| SKIL | Ski-like protein (Ski-related oncogene) (Ski-related protein) | 5 | UniProt NCBI |
| SMAD4 | Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) | 5 | UniProt NCBI |
| JMJD1C | Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001933 | 0.00739475140297 | 0.75 | JMJD1C GATA2 SMAD4 | Subcutaneous hemorrhage |
| HP:0100807 | 0.0135364936749 | 0.75 | JMJD1C GATA2 SMAD4 | Long fingers |
| HP:0011029 | 0.0183300819535 | 0.75 | JMJD1C GATA2 SMAD4 | Internal hemorrhage |
| HP:0011028 | 0.0219389426652 | 0.75 | JMJD1C GATA2 SMAD4 | Abnormality of blood circulation |
| CORUM:3197 | 0.0249718442456 | 0.25 | SMAD4 | SMAD4-SNO-SKI complex |
| CORUM:3200 | 0.0249718442456 | 0.25 | SMAD4 | SMAD4-SKI complex |
| HP:0001744 | 0.0423481317849 | 0.75 | JMJD1C GATA2 SMAD4 | Splenomegaly |
| HP:0000008 | 0.0467645338244 | 0.75 | JMJD1C GATA2 SMAD4 | Abnormal morphology of female internal genitalia |
| CORUM:2704 | 0.049938562206 | 0.25 | SMAD4 | Ectodermin-SMAD4 complex |
| CORUM:3038 | 0.049938562206 | 0.25 | SMAD4 | SMAD2-SMAD4-FAST1 complex |
| CORUM:3206 | 0.049938562206 | 0.25 | SMAD4 | SMAD4-SKI-NCOR complex |
| CORUM:3739 | 0.049938562206 | 0.25 | SMAD4 | SKI-SMAD2-SMAD4 pentameric complex |
| CORUM:3740 | 0.049938562206 | 0.25 | SMAD4 | SKI-SMAD3-SMAD4 complex |
| CORUM:3959 | 0.049938562206 | 0.25 | SMAD4 | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SKIL | SMAD4 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SKI | SMAD4 | 0.996 | 0.124 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| GATA2 | MPND | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SKI | SKIL | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| JMJD1C | MPND | 0.902 | 0.106 | bioplex3_WMM WMM_only |
| JMJD1C | SKIL | 0.902 | bioplex3_WMM WMM_only | |
| MPND | SKIL | 0.902 | bioplex3_WMM WMM_only | |
| JMJD1C | SMAD4 | 0.005 | 0.09 | youn_WMM WMM_only |
Related Complexes