hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14012.1
Complex Portal: CPX-19682
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GABARAPL1 | Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) | 5 | UniProt NCBI |
| MAP1LC3B2 | Microtubule-associated proteins 1A/1B light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3B-like) | 4 | UniProt NCBI |
| ATG3 | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | 5 | UniProt NCBI |
| TBC1D25 | TBC1 domain family member 25 | 5 | UniProt NCBI |
| RWDD2A | RWD domain-containing protein 2A | 2 | UniProt NCBI |
| GABARAP | Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46) | 5 | UniProt NCBI |
| GABARAPL2 | Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein) | 5 | UniProt NCBI |
| EPM2A | Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase) | 5 | UniProt NCBI |
| ATG4B | Cysteine protease ATG4B (EC 3.4.22.-) (AUT-like 1 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 1) (Autophagin-1) (Autophagy-related protein 4 homolog B) (HsAPG4B) (hAPG4B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04136 | 1.62548421078e-10 | 0.555555555556 | GABARAPL2 GABARAPL1 ATG4B GABARAP ATG3 | Autophagy - other |
| KEGG:04140 | 5.55493631348e-09 | 0.666666666667 | GABARAPL1 GABARAP MAP1LC3B2 ATG3 ATG4B GABARAPL2 | Autophagy - animal |
| GO:0005776 | 6.70749794698e-08 | 0.666666666667 | GABARAPL1 GABARAP MAP1LC3B2 TBC1D25 ATG4B GABARAPL2 | autophagosome |
| GO:0000422 | 8.52371644287e-08 | 0.666666666667 | GABARAPL1 GABARAP MAP1LC3B2 ATG3 ATG4B GABARAPL2 | autophagy of mitochondrion |
| GO:0043562 | 2.31823352537e-07 | 0.444444444444 | GABARAPL2 GABARAPL1 MAP1LC3B2 GABARAP | cellular response to nitrogen levels |
| GO:0006995 | 2.31823352537e-07 | 0.444444444444 | GABARAPL2 GABARAPL1 MAP1LC3B2 GABARAP | cellular response to nitrogen starvation |
| GO:0000421 | 2.67554228815e-07 | 0.555555555556 | GABARAPL2 GABARAPL1 ATG4B MAP1LC3B2 GABARAP | autophagosome membrane |
| GO:0000045 | 2.83425725426e-07 | 0.666666666667 | GABARAPL1 GABARAP MAP1LC3B2 ATG3 ATG4B GABARAPL2 | autophagosome assembly |
| GO:1905037 | 3.64187360608e-07 | 0.666666666667 | GABARAPL1 GABARAP MAP1LC3B2 ATG3 ATG4B GABARAPL2 | autophagosome organization |
| REAC:R-HSA-1632852 | 1.27732061414e-06 | 0.555555555556 | GABARAPL2 GABARAPL1 ATG4B GABARAP ATG3 | Macroautophagy |
| GO:0016236 | 1.28179479185e-06 | 0.777777777778 | GABARAPL1 GABARAP ATG4B MAP1LC3B2 ATG3 TBC1D25 GABARAPL2 | macroautophagy |
| REAC:R-HSA-9612973 | 2.25319041775e-06 | 0.555555555556 | GABARAPL2 GABARAPL1 ATG4B GABARAP ATG3 | Autophagy |
| GO:1903008 | 3.37800332391e-06 | 0.666666666667 | GABARAPL1 GABARAP MAP1LC3B2 ATG3 ATG4B GABARAPL2 | organelle disassembly |
| WP:WP5412 | 5.34493407698e-06 | 0.333333333333 | GABARAPL1 GABARAP GABARAPL2 | 8q11 23 RB1CC1 copy number variation |
| KEGG:04137 | 1.18009914552e-05 | 0.444444444444 | GABARAPL2 GABARAPL1 MAP1LC3B2 GABARAP | Mitophagy - animal |
| GO:0007033 | 1.35259454547e-05 | 0.666666666667 | GABARAPL1 GABARAP MAP1LC3B2 ATG3 ATG4B GABARAPL2 | vacuole organization |
| GO:0022411 | 2.0815903456e-05 | 0.777777777778 | GABARAPL1 GABARAP ATG4B MAP1LC3B2 ATG3 TBC1D25 GABARAPL2 | cellular component disassembly |
| WP:WP5224 | 2.81297285008e-05 | 0.444444444444 | GABARAPL1 ATG4B GABARAP GABARAPL2 | 2q37 copy number variation syndrome |
| GO:0061919 | 4.08093873419e-05 | 0.777777777778 | GABARAPL1 GABARAP ATG4B MAP1LC3B2 ATG3 TBC1D25 GABARAPL2 | process utilizing autophagic mechanism |
| GO:0006914 | 4.08093873419e-05 | 0.777777777778 | GABARAPL1 GABARAP ATG4B MAP1LC3B2 ATG3 TBC1D25 GABARAPL2 | autophagy |
| KEGG:04621 | 5.85607695532e-05 | 0.444444444444 | GABARAPL2 GABARAPL1 MAP1LC3B2 GABARAP | NOD-like receptor signaling pathway |
| REAC:R-HSA-8854214 | 0.000345852488601 | 0.333333333333 | TBC1D25 GABARAP GABARAPL2 | TBC/RABGAPs |
| KEGG:04727 | 0.000383448794118 | 0.333333333333 | GABARAPL1 GABARAP GABARAPL2 | GABAergic synapse |
| GO:0050811 | 0.000966803032193 | 0.333333333333 | GABARAPL1 GABARAP GABARAPL2 | GABA receptor binding |
| GO:0007005 | 0.00130260179847 | 0.666666666667 | GABARAPL1 GABARAP MAP1LC3B2 ATG3 ATG4B GABARAPL2 | mitochondrion organization |
| KEGG:04068 | 0.00184766477855 | 0.333333333333 | GABARAPL1 GABARAP GABARAPL2 | FoxO signaling pathway |
| REAC:R-HSA-9007101 | 0.00756314206499 | 0.333333333333 | TBC1D25 GABARAP GABARAPL2 | Rab regulation of trafficking |
| GO:0005773 | 0.0237730966843 | 0.666666666667 | GABARAPL1 GABARAP MAP1LC3B2 TBC1D25 ATG4B GABARAPL2 | vacuole |
| GO:0009267 | 0.0255085593346 | 0.444444444444 | GABARAPL2 GABARAPL1 MAP1LC3B2 GABARAP | cellular response to starvation |
| GO:0048487 | 0.0325091721374 | 0.333333333333 | GABARAPL1 GABARAP GABARAPL2 | beta-tubulin binding |
| GO:0044248 | 0.0346373539255 | 0.777777777778 | GABARAPL1 GABARAP ATG4B MAP1LC3B2 ATG3 TBC1D25 GABARAPL2 | cellular catabolic process |
| GO:0042594 | 0.0435922560843 | 0.444444444444 | GABARAPL2 GABARAPL1 MAP1LC3B2 GABARAP | response to starvation |
| GO:0005774 | 0.0458422366288 | 0.555555555556 | GABARAPL2 GABARAPL1 ATG4B MAP1LC3B2 GABARAP | vacuolar membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ATG3 | GABARAPL2 | 0.999 | 0.072 |
mutually_exclusive (Q9Y4P1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAP1LC3B2 | ATG3 | 0.999 | 0.044 |
mutually_exclusive (Q9Y4P1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ATG3 | GABARAP | 0.997 | 0.212 |
mutually_exclusive (Q9Y4P1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GABARAP | GABARAPL2 | 0.991 | 0.272 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| TBC1D25 | GABARAPL2 | 0.962 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GABARAP | RWDD2A | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GABARAPL1 | ATG4B | 0.956 | 0.114 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| GABARAPL1 | GABARAP | 0.953 | 0.404 | bioplex_WMM bioplex3_WMM WMM_only | |
| GABARAPL1 | GABARAPL2 | 0.949 | 0.25 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| TBC1D25 | GABARAP | 0.942 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG4B | GABARAP | 0.935 | 0.204 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| ATG4B | MAP1LC3B2 | 0.922 | 0.116 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| MAP1LC3B2 | GABARAP | 0.907 | 0.212 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAP1LC3B2 | GABARAPL2 | 0.895 | 0.19 | bioplex_WMM bioplex3_WMM WMM_only | |
| GABARAPL1 | EPM2A | 0.878 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GABARAP | EPM2A | 0.855 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TBC1D25 | GABARAPL1 | 0.807 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATG4B | GABARAPL2 | 0.485 | 0.092 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| GABARAPL1 | ATG3 | 0.102 | 0.09 |
mutually_exclusive (Q9Y4P1)
|
bioplex3_WMM WMM_only |
| GABARAPL1 | MAP1LC3B2 | 0.078 | 0.132 | bioplex3_WMM WMM_only | |
| GABARAPL2 | EPM2A | 0.023 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes