hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14027.1
Complex Portal: CPX-24012
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STK40 | Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495) | 5 | UniProt NCBI |
| ETV5 | ETS translocation variant 5 (Ets-related protein ERM) | 5 | UniProt NCBI |
| FOSB | Protein FosB (FosB proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 3) (Transcription factor AP-1 subunit FosB) | 5 | UniProt NCBI |
| DET1 | DET1 homolog (De-etiolated-1 homolog) | 5 | UniProt NCBI |
| WASHC1 | WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1) | 5 | UniProt NCBI |
| ETV1 | ETS translocation variant 1 (Ets-related protein 81) | 5 | UniProt NCBI |
| UBE2E2 | Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2) | 5 | UniProt NCBI |
| ETS2 | Protein C-ets-2 | 5 | UniProt NCBI |
| TRIB2 | Tribbles homolog 2 (TRB-2) | 5 | UniProt NCBI |
| COP1 | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) | 5 | UniProt NCBI |
| TRIB1 | Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1) | 5 | UniProt NCBI |
| UBE2E1 | Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04120 | 0.000111376685315 | 0.363636363636 | DET1 UBE2E1 UBE2E2 COP1 | Ubiquitin mediated proteolysis |
| CORUM:1214 | 0.000341558207359 | 0.181818181818 | DET1 COP1 | Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) |
| GO:0032436 | 0.00776238405979 | 0.363636363636 | DET1 TRIB1 TRIB2 COP1 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:2000060 | 0.0162473596436 | 0.363636363636 | DET1 TRIB1 TRIB2 COP1 | positive regulation of ubiquitin-dependent protein catabolic process |
| GO:1901800 | 0.021466373792 | 0.363636363636 | DET1 TRIB1 TRIB2 COP1 | positive regulation of proteasomal protein catabolic process |
| GO:1903052 | 0.0399279910051 | 0.363636363636 | DET1 TRIB1 TRIB2 COP1 | positive regulation of proteolysis involved in protein catabolic process |
| GO:0032434 | 0.0447114312631 | 0.363636363636 | DET1 TRIB1 TRIB2 COP1 | regulation of proteasomal ubiquitin-dependent protein catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COP1 | TRIB1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DET1 | TRIB1 | 1.0 |
structurally_consistent (Q92519)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK40 | DET1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| DET1 | COP1 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DET1 | UBE2E2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UBE2E1 | DET1 | 0.999 |
structurally_consistent (Q92519)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ETV5 | COP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ETV1 | COP1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK40 | TRIB1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TRIB2 | TRIB1 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DET1 | TRIB2 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRIB2 | COP1 | 0.998 |
structurally_consistent (Q96RU8)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK40 | TRIB2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK40 | ETV5 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ETV5 | DET1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| UBE2E1 | TRIB1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK40 | ETV1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| STK40 | COP1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| DET1 | ETV1 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| UBE2E1 | TRIB2 | 0.978 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UBE2E1 | STK40 | 0.976 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FOSB | TRIB1 | 0.96 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBE2E1 | COP1 | 0.955 | 0.094 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FOSB | COP1 | 0.954 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FOSB | STK40 | 0.943 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| COP1 | UBE2E2 | 0.936 | 0.122 |
mutually_exclusive (Q7L5Y6)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ETV5 | ETV1 | 0.902 | bioplex3_WMM WMM_only | ||
| ETV5 | UBE2E2 | 0.902 | bioplex3_WMM WMM_only | ||
| ETV1 | UBE2E2 | 0.902 | bioplex3_WMM WMM_only | ||
| COP1 | WASHC1 | 0.873 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| COP1 | ETS2 | 0.814 | hein_WMM hein () | ||
| UBE2E1 | UBE2E2 | 0.787 | 0.102 |
structurally_consistent (Q7L5Y6)
|
bioplex_WMM bioplex3_WMM WMM_only |
| STK40 | UBE2E2 | 0.733 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TRIB1 | UBE2E2 | 0.634 | bioplex3_WMM WMM_only | ||
| ETV5 | TRIB1 | 0.418 | bioplex3_WMM WMM_only | ||
| ETV1 | TRIB1 | 0.418 | bioplex3_WMM WMM_only | ||
| UBE2E1 | ETV1 | 0.356 | bioplex3_WMM WMM_only | ||
| UBE2E1 | ETV5 | 0.356 | bioplex3_WMM WMM_only | ||
| FOSB | DET1 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| UBE2E1 | WASHC1 | 0.001 | youn_WMM gupta_WMM WMM_only |
Related Complexes