hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14032.1
Complex Portal: CPX-18810
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KRT86 | Keratin, type II cuticular Hb6 (Hair keratin K2.11) (Keratin-86) (K86) (Type II hair keratin Hb6) (Type-II keratin Kb26) | 5 | UniProt NCBI |
| EXOC4 | Exocyst complex component 4 (Exocyst complex component Sec8) | 5 | UniProt NCBI |
| CROCC | Rootletin (Ciliary rootlet coiled-coil protein) | 5 | UniProt NCBI |
| KRT81 | Keratin, type II cuticular Hb1 (Hair keratin K2.9) (Keratin, hair, basic, 1) (Keratin-81) (K81) (Metastatic lymph node 137 gene protein) (MLN 137) (Type II hair keratin Hb1) (Type-II keratin Kb21) (ghHKb1) (ghHb1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0230301 | 4.3541634103e-05 | 0.5 | KRT86 KRT81 | hair; cells in cortex/medulla[>=Low] |
| HPA:0230302 | 4.3541634103e-05 | 0.5 | KRT86 KRT81 | hair; cells in cortex/medulla[>=Medium] |
| HPA:0230303 | 4.3541634103e-05 | 0.5 | KRT86 KRT81 | hair; cells in cortex/medulla[High] |
| HP:0007468 | 0.000100319571443 | 0.5 | KRT86 KRT81 | Perifollicular hyperkeratosis |
| HP:0031285 | 0.000334337547576 | 0.5 | KRT86 KRT81 | Abnormal perifollicular morphology |
| HPA:0230000 | 0.000395903520345 | 0.5 | KRT86 KRT81 | hair |
| HP:0002217 | 0.00771122114953 | 0.5 | KRT86 KRT81 | Slow-growing hair |
| HP:0002232 | 0.00771122114953 | 0.5 | KRT86 KRT81 | Patchy alopecia |
| HP:0011363 | 0.00771122114953 | 0.5 | KRT86 KRT81 | Abnormality of hair growth rate |
| HP:0040170 | 0.00844485194452 | 0.5 | KRT86 KRT81 | Abnormality of hair growth |
| HP:0007502 | 0.0135443934278 | 0.5 | KRT86 KRT81 | Follicular hyperkeratosis |
| HP:0032152 | 0.0145105245688 | 0.5 | KRT86 KRT81 | Keratosis pilaris |
| HP:0011360 | 0.0198386649826 | 0.5 | KRT86 KRT81 | Acquired abnormal hair pattern |
| REAC:R-HSA-6809371 | 0.022534212454 | 0.5 | KRT86 KRT81 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 0.0239057396727 | 0.5 | KRT86 KRT81 | Keratinization |
| HP:0002299 | 0.0329787201379 | 0.5 | KRT86 KRT81 | Brittle hair |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KRT86 | EXOC4 | 0.973 | 0.056 | bioplex3_HEK293 bioplex () bioplex3_HCT116 boldt_WMM | |
| EXOC4 | KRT81 | 0.922 | bioplex3_HEK293 youn_WMM WMM_only boldt_WMM | ||
| CROCC | EXOC4 | 0.877 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| KRT86 | KRT81 | 0.697 | WMM_only boldt_WMM | ||
| CROCC | KRT86 | 0.008 | 0.072 | WMM_only boldt_WMM |
Related Complexes