hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14038.1
Complex Portal: CPX-13271
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BARD1 | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | 5 | UniProt NCBI |
| MDC1 | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | 5 | UniProt NCBI |
| EBF3 | Transcription factor COE3 (Early B-cell factor 3) (EBF-3) (Olf-1/EBF-like 2) (O/E-2) (OE-2) | 5 | UniProt NCBI |
| CCDC85A | Coiled-coil domain-containing protein 85A | 3 | UniProt NCBI |
| ASTE1 | Protein asteroid homolog 1 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4016 | 0.017034501082 | 0.4 | BARD1 MDC1 | DNA IR damage and cellular response via ATR |
| REAC:R-HSA-5693571 | 0.0275944536635 | 0.4 | BARD1 MDC1 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-5693565 | 0.0374197925333 | 0.4 | BARD1 MDC1 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.0384836492499 | 0.4 | BARD1 MDC1 | DNA Double Strand Break Response |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CCDC85A | ASTE1 | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| BARD1 | CCDC85A | 0.97 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CCDC85A | MDC1 | 0.87 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CCDC85A | EBF3 | 0.85 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| BARD1 | ASTE1 | 0.415 | 0.216 | bioplex3_WMM WMM_only | |
| BARD1 | EBF3 | 0.274 | 0.114 | bioplex3_WMM WMM_only | |
| BARD1 | MDC1 | 0.25 | 0.38 | bioplex3_WMM WMM_only | |
| MDC1 | ASTE1 | 0.113 | 0.096 | bioplex3_WMM WMM_only | |
| ASTE1 | EBF3 | 0.113 | 0.042 | bioplex3_WMM WMM_only | |
| MDC1 | EBF3 | 0.078 | 0.074 | bioplex3_WMM WMM_only |
Related Complexes