hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14041.1
Complex Portal: CPX-12436
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZBTB6 | Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) (Zinc finger protein with interaction domain) | 5 | UniProt NCBI |
| ACKR4 | Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR) | 5 | UniProt NCBI |
| CYP2A13 | Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13) | 5 | UniProt NCBI |
| TIMM10B | Mitochondrial import inner membrane translocase subunit Tim10 B (Fracture callus protein 1) (FxC1) (Mitochondrial import inner membrane translocase subunit Tim9 B) (TIMM10B) (Tim10b) | 5 | UniProt NCBI |
| TIMM10 | Mitochondrial import inner membrane translocase subunit Tim10 | 5 | UniProt NCBI |
| TIMM9 | Mitochondrial import inner membrane translocase subunit Tim9 | 5 | UniProt NCBI |
| PRR27 | Proline-rich protein 27 | 2 | UniProt NCBI |
| SAA2 | Serum amyloid A-2 protein (SAA2) [Cleaved into: Amyloid A2 protein (AA2)] | 5 | UniProt NCBI |
| TIMM29 | Mitochondrial import inner membrane translocase subunit Tim29 (TIM29) | 4 | UniProt NCBI |
| SMR3B | Submaxillary gland androgen-regulated protein 3B (Proline-rich peptide P-B) (Proline-rich protein 3) [Cleaved into: Peptide P-A; Peptide D1A] | 5 | UniProt NCBI |
| LPO | Lactoperoxidase (LPO) (EC 1.11.1.7) (Salivary peroxidase) (SPO) | 5 | UniProt NCBI |
| ADCYAP1 | Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] | 5 | UniProt NCBI |
| MGP | Matrix Gla protein (MGP) (Cell growth-inhibiting gene 36 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0042721 | 2.81924903404e-07 | 0.307692307692 | TIMM10B TIMM29 TIMM10 TIMM9 | TIM22 mitochondrial import inner membrane insertion complex |
| GO:0045039 | 9.27604366858e-06 | 0.307692307692 | TIMM10B TIMM29 TIMM10 TIMM9 | protein insertion into mitochondrial inner membrane |
| CORUM:623 | 4.10333215354e-05 | 0.153846153846 | TIMM9 TIMM10 | TIM (TIM9, TIM10) complex, mitochondrial |
| GO:0090151 | 0.000441365385974 | 0.307692307692 | TIMM10B TIMM29 TIMM10 TIMM9 | establishment of protein localization to mitochondrial membrane |
| GO:0042719 | 0.000548960443183 | 0.230769230769 | TIMM10B TIMM10 TIMM9 | mitochondrial intermembrane space protein transporter complex |
| GO:0007007 | 0.00168910935121 | 0.307692307692 | TIMM10B TIMM29 TIMM10 TIMM9 | inner mitochondrial membrane organization |
| REAC:R-HSA-1268020 | 0.0049922040089 | 0.230769230769 | TIMM10B TIMM10 TIMM9 | Mitochondrial protein import |
| GO:0005758 | 0.00833329666432 | 0.307692307692 | TIMM10B TIMM29 TIMM10 TIMM9 | mitochondrial intermembrane space |
| GO:0031970 | 0.0123598285834 | 0.307692307692 | TIMM10B TIMM29 TIMM10 TIMM9 | organelle envelope lumen |
| GO:0007006 | 0.0366003090215 | 0.307692307692 | TIMM10B TIMM29 TIMM10 TIMM9 | mitochondrial membrane organization |
| GO:0006626 | 0.0481684735813 | 0.307692307692 | TIMM10B TIMM29 TIMM10 TIMM9 | protein targeting to mitochondrion |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TIMM10B | TIMM10 | 0.999 | 0.65 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| TIMM10 | TIMM9 | 0.999 | 0.82 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| TIMM10 | TIMM29 | 0.996 | 0.606 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 WMM_only boldt_WMM | |
| TIMM10 | LPO | 0.964 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TIMM10 | PRR27 | 0.964 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TIMM10 | MGP | 0.955 | 0.036 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SAA2 | TIMM10 | 0.945 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TIMM10B | CYP2A13 | 0.93 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TIMM10 | ACKR4 | 0.91 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TIMM10 | ZBTB6 | 0.91 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SMR3B | TIMM10 | 0.908 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SMR3B | MGP | 0.904 | bioplex3_WMM WMM_only | ||
| SMR3B | PRR27 | 0.904 | bioplex3_WMM WMM_only | ||
| PRR27 | MGP | 0.902 | bioplex3_WMM WMM_only | ||
| PRR27 | LPO | 0.902 | bioplex3_WMM WMM_only | ||
| SAA2 | LPO | 0.902 | bioplex3_WMM WMM_only | ||
| LPO | MGP | 0.902 | bioplex3_WMM WMM_only | ||
| SAA2 | MGP | 0.902 | bioplex3_WMM WMM_only | ||
| SAA2 | PRR27 | 0.902 | bioplex3_WMM WMM_only | ||
| TIMM9 | TIMM29 | 0.896 | 0.434 | bioplex_WMM bioplex3_WMM boldt WMM_only boldt_WMM | |
| SMR3B | LPO | 0.892 | bioplex3_WMM WMM_only | ||
| SAA2 | SMR3B | 0.892 | bioplex3_WMM WMM_only | ||
| TIMM10B | TIMM29 | 0.874 | 0.61 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| ADCYAP1 | TIMM10 | 0.864 |
mutually_exclusive (Q9Y5J6)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ADCYAP1 | TIMM10B | 0.847 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TIMM10B | TIMM9 | 0.767 | 0.696 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| TIMM10B | LPO | 0.715 | bioplex3_WMM WMM_only | ||
| TIMM10 | CYP2A13 | 0.665 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MGP | TIMM29 | 0.652 | 0.052 | bioplex3_WMM WMM_only | |
| PRR27 | TIMM29 | 0.652 | bioplex3_WMM WMM_only | ||
| LPO | TIMM29 | 0.582 | bioplex3_WMM WMM_only | ||
| SAA2 | TIMM29 | 0.582 | bioplex3_WMM WMM_only | ||
| SMR3B | TIMM29 | 0.545 | bioplex3_WMM WMM_only | ||
| TIMM10B | MGP | 0.478 | 0.012 | bioplex3_WMM WMM_only | |
| TIMM10B | PRR27 | 0.478 | bioplex3_WMM WMM_only | ||
| SAA2 | TIMM10B | 0.41 | bioplex3_WMM WMM_only | ||
| SMR3B | TIMM10B | 0.364 | bioplex3_WMM WMM_only | ||
| TIMM9 | LPO | 0.363 | bioplex3_WMM WMM_only | ||
| SAA2 | TIMM9 | 0.341 | bioplex3_WMM WMM_only | ||
| TIMM9 | MGP | 0.321 | 0.034 | bioplex3_WMM WMM_only | |
| TIMM9 | PRR27 | 0.233 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SMR3B | TIMM9 | 0.217 | bioplex3_WMM WMM_only | ||
| ADCYAP1 | TIMM9 | 0.049 |
mutually_exclusive (Q9Y5J6)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TIMM9 | CYP2A13 | 0.043 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes