hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14050.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SSX4 | Protein SSX4 (Cancer/testis antigen 5.4) (CT5.4) | 3 | UniProt NCBI |
| SIM2 | Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15) | 5 | UniProt NCBI |
| NPAS3 | Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6) | 5 | UniProt NCBI |
| SIM1 | Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14) | 4 | UniProt NCBI |
| HIF1A | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) | 5 | UniProt NCBI |
| ARNT2 | Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1) | 5 | UniProt NCBI |
| ARNT | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4241 | 0.00290547066497 | 0.4 | HIF1A ARNT2 | Type 2 papillary renal cell carcinoma |
| GO:0046982 | 0.0042756506291 | 0.8 | HIF1A ARNT2 NPAS3 SIM1 | protein heterodimerization activity |
| KEGG:05211 | 0.00937366158534 | 0.4 | HIF1A ARNT2 | Renal cell carcinoma |
| GO:0000981 | 0.0378314216665 | 1.0 | SIM2 HIF1A ARNT2 NPAS3 SIM1 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | 0.0435745197674 | 1.0 | SIM2 HIF1A ARNT2 NPAS3 SIM1 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SSX4 | HIF1A | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ARNT2 | SIM2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HIF1A | ARNT | 0.997 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| SIM1 | ARNT2 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SIM2 | ARNT | 0.993 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NPAS3 | ARNT2 | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ARNT2 | HIF1A | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NPAS3 | ARNT | 0.954 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ARNT2 | ARNT | 0.827 | bioplex_WMM bioplex3_WMM WMM_only | |
| SIM1 | HIF1A | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| SIM1 | SIM2 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| HIF1A | SIM2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes