hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14054.1

Complex Portal: CPX-16131

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
KIF5B	Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)	5	UniProt NCBI
RAB11FIP1	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein)	5	UniProt NCBI
KIF5C	Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1)	5	UniProt NCBI
PPIL2	RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Cyp60) (hCyP-60) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase) (Rotamase PPIL2)	5	UniProt NCBI
KLC4	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8)	5	UniProt NCBI
SYNE4	Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4)	5	UniProt NCBI
DAPK2	Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1)	5	UniProt NCBI
KLC3	Kinesin light chain 3 (KLC2-like) (kinesin light chain 2)	5	UniProt NCBI
MYCL	Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog)	5	UniProt NCBI
KIF5A	Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC)	5	UniProt NCBI
KLC2	Kinesin light chain 2 (KLC 2)	5	UniProt NCBI
KLC1	Kinesin light chain 1 (KLC 1)	5	UniProt NCBI
RAB11FIP2	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5625970	8.56420099607e-15	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	RHO GTPases activate KTN1
REAC:R-HSA-983189	4.71560424801e-10	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	Kinesins
KEGG:04814	7.0931747582e-10	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Motor proteins
KEGG:05132	6.97866834377e-09	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Salmonella infection
KEGG:05012	1.06824715628e-08	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Parkinson disease
KEGG:05020	1.30914525774e-08	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Prion disease
REAC:R-HSA-6811434	1.37268471217e-08	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	COPI-dependent Golgi-to-ER retrograde traffic
WP:WP5124	1.94709626082e-08	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Alzheimer 39 s disease
WP:WP2059	1.94709626082e-08	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Alzheimer 39 s disease and miRNA effects
KEGG:05016	2.65346018451e-08	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Huntington disease
REAC:R-HSA-2132295	5.58466919025e-08	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	MHC class II antigen presentation
REAC:R-HSA-8856688	8.76642297776e-08	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	Golgi-to-ER retrograde transport
KEGG:05014	9.23467021155e-08	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Amyotrophic lateral sclerosis
KEGG:05010	1.29175755641e-07	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Alzheimer disease
REAC:R-HSA-983231	3.32435514942e-07	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	Factors involved in megakaryocyte development and platelet production
KEGG:05022	5.06818125237e-07	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	Pathways of neurodegeneration - multiple diseases
REAC:R-HSA-6811442	1.15347159193e-06	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	Intra-Golgi and retrograde Golgi-to-ER traffic
GO:0005871	3.06908842743e-06	0.416666666667	KLC2 KIF5C KLC1 KIF5B KIF5A	kinesin complex
REAC:R-HSA-109582	1.36521432448e-05	0.583333333333	PPIL2 KIF5B KIF5A KLC4 KLC1 KLC2 KLC3	Hemostasis
REAC:R-HSA-195258	1.48729505548e-05	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	RHO GTPase Effectors
GO:0007018	2.5526286975e-05	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	microtubule-based movement
KEGG:04144	3.55265921393e-05	0.416666666667	RAB11FIP1 KIF5A KIF5B RAB11FIP2 KIF5C	Endocytosis
GO:0098971	8.45465618902e-05	0.25	KIF5C KIF5B KIF5A	anterograde dendritic transport of neurotransmitter receptor complex
REAC:R-HSA-264876	0.000151585507878	0.25	KIF5C KIF5B KIF5A	Insulin processing
GO:0019894	0.000305979485619	0.333333333333	KLC2 KLC1 KLC4 KLC3	kinesin binding
GO:0098935	0.00042234232358	0.25	KIF5C KIF5B KIF5A	dendritic transport
GO:0098937	0.00042234232358	0.25	KIF5C KIF5B KIF5A	anterograde dendritic transport
REAC:R-HSA-199991	0.000726083969512	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	Membrane Trafficking
REAC:R-HSA-5653656	0.000995748522715	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	Vesicle-mediated transport
KEGG:05223	0.00106901690596	0.25	KIF5C KIF5B KIF5A	Non-small cell lung cancer
GO:0099641	0.00118146610329	0.25	KIF5C KIF5B KIF5A	anterograde axonal protein transport
GO:0099640	0.00118146610329	0.25	KIF5C KIF5B KIF5A	axo-dendritic protein transport
REAC:R-HSA-194315	0.00125933631452	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	Signaling by Rho GTPases
REAC:R-HSA-9716542	0.00143029647214	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
GO:0005875	0.00146978806891	0.416666666667	KLC2 KIF5C KLC1 KIF5B KIF5A	microtubule associated complex
REAC:R-HSA-1280218	0.00170710600228	0.5	KIF5B KIF5A KLC3 KLC1 KLC2 KLC4	Adaptive Immune System
GO:0098840	0.00252937426606	0.25	KIF5C KIF5B KIF5A	protein transport along microtubule
GO:1905383	0.00252937426606	0.25	KIF5C KIF5B KIF5A	protein localization to presynapse
GO:0099118	0.00252937426606	0.25	KIF5C KIF5B KIF5A	microtubule-based protein transport
KEGG:04728	0.00439386768759	0.25	KIF5C KIF5B KIF5A	Dopaminergic synapse
REAC:R-HSA-2980736	0.00510802930332	0.25	KIF5C KIF5B KIF5A	Peptide hormone metabolism
GO:0008574	0.00765826511887	0.25	KIF5C KIF5B KIF5A	plus-end-directed microtubule motor activity
GO:0007017	0.0169797109462	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	microtubule-based process
GO:0008092	0.0198314734719	0.583333333333	KIF5B KIF5A KLC1 KLC3 KIF5C KLC2 KLC4	cytoskeletal protein binding
GO:0003774	0.0306371941249	0.333333333333	KIF5C KLC1 KIF5B KIF5A	cytoskeletal motor activity
WP:WP4535	0.0499291233461	0.166666666667	KIF5B SYNE4	Envelope proteins and their potential roles in EDMD physiopathology
CORUM:5401	0.0499436884912	0.0833333333333	KIF5B	PLEKHM2-KIF5B complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
KLC4	KLC3	1.0	0.206
KIF5A	KLC1	1.0	0.136
KLC4	KLC1	1.0	0.274
KIF5B	KLC1	1.0	0.584
KIF5C	KLC1	1.0	0.102
KLC3	KIF5A	1.0	0.094
KIF5B	KLC3	1.0	0.18
KLC3	KLC2	1.0	0.138	structurally_consistent (dimer)
KIF5B	KLC2	1.0	0.478
KLC2	KLC1	1.0	0.682
MYCL	KLC4	0.999
MYCL	KLC3	0.999
KIF5C	KLC3	0.999	0.154	structurally_consistent (dimer)
KIF5C	SYNE4	0.999
KLC4	KLC2	0.999	0.154
KLC3	KLC1	0.999	0.1
SYNE4	KLC1	0.999
SYNE4	KLC3	0.999
KIF5C	KLC4	0.999	0.126
KIF5B	KLC4	0.998	0.22
KLC4	SYNE4	0.998
KIF5C	KLC2	0.998	0.154	mutually_exclusive (Q6P597)
KIF5B	SYNE4	0.998
SYNE4	KLC2	0.998
KLC4	KIF5A	0.997	0.322
MYCL	KIF5C	0.997
SYNE4	KIF5A	0.996
RAB11FIP2	RAB11FIP1	0.995	0.076
MYCL	KIF5B	0.994
MYCL	KLC2	0.992
KIF5C	KIF5A	0.99	0.186
KIF5B	KIF5A	0.985	0.2028
KLC4	RAB11FIP1	0.984	0.02
KIF5A	KLC2	0.983	0.14
KLC4	RAB11FIP2	0.98	0.08
MYCL	KLC1	0.974
KIF5B	KIF5C	0.97	0.374
DAPK2	PPIL2	0.968
RAB11FIP2	PPIL2	0.958	0.064
MYCL	KIF5A	0.951
KIF5A	PPIL2	0.951	0.054
KIF5B	RAB11FIP2	0.942	0.209333333333
RAB11FIP1	PPIL2	0.889	0.022
KLC4	PPIL2	0.887	0.022
KLC2	PPIL2	0.885	0.028
KIF5B	RAB11FIP1	0.877	0.084
KLC2	RAB11FIP1	0.853	0.054
KLC2	RAB11FIP2	0.731	0.074
DAPK2	RAB11FIP2	0.677
KLC3	RAB11FIP2	0.642	0.098
KLC3	RAB11FIP1	0.636	0.098
KIF5A	RAB11FIP2	0.626	0.114
KLC3	DAPK2	0.6
KLC1	RAB11FIP2	0.512	0.082
DAPK2	RAB11FIP1	0.412
KLC4	DAPK2	0.35
KIF5B	DAPK2	0.302
KLC3	PPIL2	0.291	0.086
KIF5C	RAB11FIP2	0.266	0.098
KIF5B	PPIL2	0.22	0.046
KIF5C	DAPK2	0.21
KLC1	RAB11FIP1	0.183	0.104
KLC2	DAPK2	0.093
KIF5C	RAB11FIP1	0.092	0.068
KIF5C	PPIL2	0.091	0.122
KIF5A	DAPK2	0.078
KLC1	DAPK2	0.078
MYCL	RAB11FIP1	0.022
KIF5A	RAB11FIP1	0.019	0.126
KLC1	PPIL2	0.019	0.026

Related Complexes

Genename	Complexes
KIF5B	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
RAB11FIP1	huMAP3_08755.1 huMAP3_10796.1 huMAP3_12721.1 huMAP3_13297.1 huMAP3_14054.1 huMAP3_15056.1
KIF5C	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
PPIL2	huMAP3_11433.1 huMAP3_13885.1 huMAP3_14054.1
KLC4	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
SYNE4	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_11833.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
DAPK2	huMAP3_04760.1 huMAP3_13885.1 huMAP3_14054.1
KLC3	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
MYCL	huMAP3_01125.1 huMAP3_04039.1 huMAP3_06087.1 huMAP3_07843.1 huMAP3_09291.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_10481.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14306.1 huMAP3_14331.1
KIF5A	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
KLC2	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
KLC1	huMAP3_04401.1 huMAP3_09851.1 huMAP3_10340.1 huMAP3_11266.1 huMAP3_12367.1 huMAP3_14054.1 huMAP3_14331.1
RAB11FIP2	huMAP3_05328.1 huMAP3_08755.1 huMAP3_10796.1 huMAP3_12721.1 huMAP3_13297.1 huMAP3_14054.1 huMAP3_15056.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14054.1

Complex Portal: CPX-16131