hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14067.1
Complex Portal: CPX-24430
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CD99L2 | CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) | 5 | UniProt NCBI |
| GRM4 | Metabotropic glutamate receptor 4 (mGluR4) | 5 | UniProt NCBI |
| GRM7 | Metabotropic glutamate receptor 7 (mGluR7) | 5 | UniProt NCBI |
| RNF111 | E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP501 | 9.18788843787e-05 | 0.5 | GRM7 GRM4 | GPCRs class C metabotropic glutamate pheromone |
| REAC:R-HSA-420499 | 0.000931962666506 | 0.5 | GRM7 GRM4 | Class C/3 (Metabotropic glutamate/pheromone receptors) |
| GO:0007196 | 0.0028092043205 | 0.5 | GRM7 GRM4 | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway |
| KEGG:04724 | 0.00806816574582 | 0.5 | GRM7 GRM4 | Glutamatergic synapse |
| GO:0001640 | 0.00842684400117 | 0.5 | GRM7 GRM4 | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity |
| GO:0098988 | 0.00842684400117 | 0.5 | GRM7 GRM4 | G protein-coupled glutamate receptor activity |
| WP:WP5083 | 0.0154364529098 | 0.5 | GRM7 GRM4 | Neuroinflammation and glutamatergic signaling |
| KEGG:04072 | 0.0165563012031 | 0.5 | GRM7 GRM4 | Phospholipase D signaling pathway |
| CORUM:6357 | 0.0249718442456 | 0.25 | GRM4 | Glutamate receptor 4 complex, metabotropic |
| CORUM:6358 | 0.0249718442456 | 0.25 | GRM7 | Glutamate receptor 7 complex, metabotropic |
| CORUM:6363 | 0.0249718442456 | 0.25 | GRM4 | mGluR2-mGluR4 complex |
| CORUM:6367 | 0.0249718442456 | 0.25 | GRM7 | mGluR2-mGluR7 complex |
| GO:0007216 | 0.042122686785 | 0.5 | GRM7 GRM4 | G protein-coupled glutamate receptor signaling pathway |
| KEGG:04080 | 0.0428875882852 | 0.5 | GRM7 GRM4 | Neuroactive ligand-receptor interaction |
| CORUM:6369 | 0.049938562206 | 0.25 | GRM4 | mGluR3-mGluR4 complex |
| CORUM:6370 | 0.049938562206 | 0.25 | GRM7 | mGluR3-mGluR7 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF111 | CD99L2 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CD99L2 | GRM4 | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GRM4 | GRM7 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CD99L2 | GRM7 | 0.415 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| CD99L2 | huMAP3_02210.1 huMAP3_07682.1 huMAP3_14067.1 |
| GRM4 | huMAP3_02210.1 huMAP3_07682.1 huMAP3_14067.1 |
| GRM7 | huMAP3_02210.1 huMAP3_14067.1 |
| RNF111 | huMAP3_01759.1 huMAP3_06386.1 huMAP3_08083.1 huMAP3_10162.1 huMAP3_14051.1 huMAP3_14067.1 |