hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14070.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
KLF15	Krueppel-like factor 15 (Kidney-enriched krueppel-like factor)	5	UniProt NCBI
UBXN11	UBX domain-containing protein 11 (Colorectal tumor-associated antigen COA-1) (Socius) (UBX domain-containing protein 5)	5	UniProt NCBI
TMEM44	Transmembrane protein 44	4	UniProt NCBI
TESPA1	Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1)	5	UniProt NCBI
COL1A2	Collagen alpha-2(I) chain (Alpha-2 type I collagen)	5	UniProt NCBI
COL3A1	Collagen alpha-1(III) chain	5	UniProt NCBI
CBLL2	E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2)	5	UniProt NCBI
COL1A1	Collagen alpha-1(I) chain (Alpha-1 type I collagen)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0025019	5.19044521616e-06	0.375	COL1A2 COL3A1 COL1A1	Arterial rupture
REAC:R-HSA-3000480	1.55196545534e-05	0.375	COL1A2 COL3A1 COL1A1	Scavenging by Class A Receptors
WP:WP453	1.7306520512e-05	0.375	COL1A2 COL3A1 COL1A1	Inflammatory response pathway
REAC:R-HSA-3000170	3.51023480424e-05	0.375	COL1A2 COL3A1 COL1A1	Syndecan interactions
REAC:R-HSA-8874081	4.61108204583e-05	0.375	COL1A2 COL3A1 COL1A1	MET activates PTK2 signaling
REAC:R-HSA-8948216	9.23525641109e-05	0.375	COL1A2 COL3A1 COL1A1	Collagen chain trimerization
REAC:R-HSA-8875878	0.000135977842763	0.375	COL1A2 COL3A1 COL1A1	MET promotes cell motility
REAC:R-HSA-2173782	0.000148687552241	0.375	COL1A2 COL3A1 COL1A1	Binding and Uptake of Ligands by Scavenger Receptors
HP:0010648	0.00016351678001	0.375	COL1A2 COL3A1 COL1A1	Dermal translucency
GO:0005583	0.0001882019462	0.375	COL1A2 COL3A1 COL1A1	fibrillar collagen trimer
GO:0098643	0.0001882019462	0.375	COL1A2 COL3A1 COL1A1	banded collagen fibril
HP:0005897	0.000226027933833	0.25	COL1A2 COL1A1	Severe generalized osteoporosis
HP:0005623	0.000226027933833	0.25	COL1A2 COL1A1	Absent ossification of calvaria
HP:0005005	0.000226027933833	0.25	COL1A2 COL1A1	Femoral bowing present at birth, straightening with time
HP:0003321	0.000226027933833	0.25	COL1A2 COL1A1	Biconcave flattened vertebrae
KEGG:04974	0.000274533958445	0.375	COL1A2 COL3A1 COL1A1	Protein digestion and absorption
REAC:R-HSA-2022090	0.000367233569698	0.375	COL1A2 COL3A1 COL1A1	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-3000171	0.000391615111842	0.375	COL1A2 COL3A1 COL1A1	Non-integrin membrane-ECM interactions
HP:0001030	0.00041417216178	0.375	COL1A2 COL3A1 COL1A1	Fragile skin
REAC:R-HSA-1442490	0.000417047988419	0.375	COL1A2 COL3A1 COL1A1	Collagen degradation
REAC:R-HSA-1650814	0.000499872649354	0.375	COL1A2 COL3A1 COL1A1	Collagen biosynthesis and modifying enzymes
HP:0000015	0.000502461035825	0.375	COL1A2 COL3A1 COL1A1	Bladder diverticulum
HP:0001075	0.000502461035825	0.375	COL1A2 COL3A1 COL1A1	Atrophic scars
KEGG:05146	0.000533899657075	0.375	COL1A2 COL3A1 COL1A1	Amoebiasis
KEGG:04933	0.000552825145721	0.375	COL1A2 COL3A1 COL1A1	AGE-RAGE signaling pathway in diabetic complications
HP:0006201	0.000677898190386	0.25	COL1A2 COL3A1	Hypermobility of distal interphalangeal joints
REAC:R-HSA-3000178	0.000696845667831	0.375	COL1A2 COL3A1 COL1A1	ECM proteoglycans
HP:0006094	0.000714829774892	0.375	COL1A2 COL3A1 COL1A1	Finger joint hypermobility
KEGG:04611	0.000791024458035	0.375	COL1A2 COL3A1 COL1A1	Platelet activation
GO:0048407	0.000886327111509	0.375	COL1A2 COL3A1 COL1A1	platelet-derived growth factor binding
REAC:R-HSA-216083	0.00089567252269	0.375	COL1A2 COL3A1 COL1A1	Integrin cell surface interactions
HP:0006256	0.00097969826768	0.375	COL1A2 COL3A1 COL1A1	Abnormality of hand joint mobility
KEGG:04926	0.00105904735548	0.375	COL1A2 COL3A1 COL1A1	Relaxin signaling pathway
REAC:R-HSA-6806834	0.00117991190651	0.375	COL1A2 COL3A1 COL1A1	Signaling by MET
REAC:R-HSA-1474290	0.00134205528321	0.375	COL1A2 COL3A1 COL1A1	Collagen formation
HP:0005620	0.00135542525381	0.25	COL1A2 COL3A1	Hypermobility of interphalangeal joints
HP:0003023	0.00135542525381	0.25	COL1A2 COL1A1	Bowing of limbs due to multiple fractures
HP:0030009	0.00135542525381	0.25	COL1A1 COL3A1	Cervical insufficiency
HP:0430046	0.00158671640143	0.375	COL1A2 COL3A1 COL1A1	Small joint hypermobilty
GO:0098644	0.00195378579303	0.375	COL1A2 COL3A1 COL1A1	complex of collagen trimers
REAC:R-HSA-430116	0.00200443712543	0.25	COL1A2 COL1A1	GP1b-IX-V activation signalling
HP:0005758	0.00225842370351	0.25	COL1A2 COL1A1	Basilar impression
HP:0000362	0.00225842370351	0.25	COL1A2 COL1A1	Otosclerosis
HP:0000993	0.00225842370351	0.25	COL1A1 COL3A1	Molluscoid pseudotumors
REAC:R-HSA-75892	0.00250486048439	0.25	COL1A2 COL1A1	Platelet Adhesion to exposed collagen
HP:0002616	0.00282342641276	0.375	COL1A2 COL3A1 COL1A1	Aortic root aneurysm
WP:WP3967	0.00285973689486	0.25	COL1A1 COL3A1	miR 509 3p alteration of YAP1 ECM axis
HP:0000974	0.00312963323221	0.375	COL1A2 COL3A1 COL1A1	Hyperextensible skin
REAC:R-HSA-198933	0.00329649801499	0.375	COL1A2 COL3A1 COL1A1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
HP:0006367	0.00338670821406	0.25	COL1A2 COL1A1	Crumpled long bones
HP:0000139	0.00338670821406	0.25	COL1A1 COL3A1	Uterine prolapse
HP:0100823	0.00338670821406	0.25	COL1A1 COL3A1	Genital hernia
WP:WP2911	0.00364416819939	0.25	COL1A2 COL3A1	miRNA targets in ECM and membrane receptors
REAC:R-HSA-1474228	0.00418264558662	0.375	COL1A2 COL3A1 COL1A1	Degradation of the extracellular matrix
REAC:R-HSA-2214320	0.00433819320746	0.25	COL1A2 COL1A1	Anchoring fibril formation
HP:0000987	0.0043733297498	0.375	COL1A2 COL3A1 COL1A1	Atypical scarring of skin
HP:0025487	0.00457399874308	0.375	COL1A2 COL3A1 COL1A1	Abnormal bladder morphology
HP:0000923	0.00474009355523	0.25	COL1A2 COL1A1	Beaded ribs
KEGG:05415	0.0050295788442	0.375	COL1A2 COL3A1 COL1A1	Diabetic cardiomyopathy
WP:WP5036	0.00656300097601	0.25	COL1A2 COL1A1	Angiotensin II receptor type 1 pathway
REAC:R-HSA-2243919	0.00666866305696	0.25	COL1A2 COL1A1	Crosslinking of collagen fibrils
HP:0000444	0.00719699823904	0.375	COL1A2 COL3A1 COL1A1	Convex nasal ridge
HP:0001787	0.00747547628793	0.375	COL1A2 COL3A1 COL1A1	Abnormal delivery
HP:0000963	0.00776099654762	0.375	COL1A2 COL3A1 COL1A1	Thin skin
HP:0008921	0.00812142628406	0.25	COL1A2 COL1A1	Neonatal short-limb short stature
HP:0004947	0.00812142628406	0.25	COL1A1 COL3A1	Arteriovenous fistula
GO:0005581	0.00948397324055	0.375	COL1A2 COL3A1 COL1A1	collagen trimer
HP:0001073	0.0101490036868	0.25	COL1A1 COL3A1	Cigarette-paper scars
HP:0100699	0.0103089116999	0.375	COL1A2 COL3A1 COL1A1	Scarring
WP:WP4786	0.0110360515043	0.25	COL1A2 COL1A1	Type I collagen synthesis in the context of osteogenesis imperfecta
HP:0000592	0.0121523513052	0.375	COL1A2 COL3A1 COL1A1	Blue sclerae
HP:0004334	0.0121523513052	0.375	COL1A2 COL3A1 COL1A1	Dermal atrophy
HP:0008628	0.0124009419501	0.25	COL1A2 COL1A1	Abnormality of the stapes
HP:0031869	0.0124009419501	0.25	COL1A2 COL1A1	Recurrent joint dislocation
GO:0005584	0.0131096201623	0.25	COL1A2 COL1A1	collagen type I trimer
HP:0012888	0.014877056319	0.25	COL1A1 COL3A1	Abnormal uterine cervix morphology
HP:0003179	0.014877056319	0.25	COL1A2 COL1A1	Protrusio acetabuli
HP:0005294	0.014877056319	0.25	COL1A1 COL3A1	Arterial dissection
HP:0001027	0.014877056319	0.25	COL1A2 COL1A1	Soft, doughy skin
HP:0012727	0.0150811755534	0.375	COL1A2 COL3A1 COL1A1	Thoracic aortic aneurysm
WP:WP5373	0.0175479862645	0.25	COL1A1 COL3A1	Role of hypoxia angiogenesis and FGF pathway in OA chondrocyte hypertrophy
HP:0010547	0.0175771621337	0.25	COL1A2 COL1A1	Muscle flaccidity
HP:0001634	0.0189590896926	0.375	COL1A2 COL3A1 COL1A1	Mitral valve prolapse
REAC:R-HSA-114604	0.0194471683576	0.25	COL1A2 COL1A1	GPVI-mediated activation cascade
GO:0030020	0.0195375863112	0.375	COL1A2 COL3A1 COL1A1	extracellular matrix structural constituent conferring tensile strength
REAC:R-HSA-76009	0.0209373692109	0.25	COL1A2 COL1A1	Platelet Aggregation (Plug Formation)
WP:WP3932	0.0231589023106	0.375	COL1A2 COL3A1 COL1A1	Focal adhesion PI3K Akt mTOR signaling pathway
HP:0000591	0.0234438911048	0.375	COL1A2 COL3A1 COL1A1	Abnormal sclera morphology
HP:0003834	0.0236486099347	0.25	COL1A2 COL1A1	Shoulder dislocation
WP:WP5144	0.0255436500108	0.25	COL1A2 COL1A1	NRP1 triggered signaling pathways in pancreatic cancer
HP:0001788	0.0270195830756	0.25	COL1A1 COL3A1	Premature rupture of membranes
KEGG:04512	0.0281919479502	0.25	COL1A2 COL1A1	ECM-receptor interaction
HP:0100541	0.0306138099712	0.25	COL1A2 COL1A1	Femoral hernia
HP:0005855	0.0306138099712	0.25	COL1A2 COL1A1	Multiple prenatal fractures
HP:0005474	0.0306138099712	0.25	COL1A2 COL1A1	Decreased calvarial ossification
HP:0002691	0.0306138099712	0.25	COL1A2 COL1A1	Platybasia
HP:0040160	0.0306138099712	0.25	COL1A2 COL1A1	Generalized osteoporosis
HP:0000703	0.0344311064357	0.25	COL1A2 COL1A1	Dentinogenesis imperfecta
HP:0004452	0.0344311064357	0.25	COL1A2 COL1A1	Abnormality of the middle ear ossicles
HP:0031654	0.0367737328953	0.375	COL1A2 COL3A1 COL1A1	Abnormal pulmonary valve physiology
WP:WP5055	0.0376097283422	0.25	COL1A2 COL1A1	Burn wound healing
HP:0001633	0.0384126917091	0.375	COL1A2 COL3A1 COL1A1	Abnormal mitral valve morphology
HP:0004942	0.0392499036244	0.375	COL1A2 COL3A1 COL1A1	Aortic aneurysm
WP:WP5158	0.0402976114103	0.25	COL1A1 COL3A1	Urotensin II mediated signaling pathway
REAC:R-HSA-1474244	0.0421371538836	0.375	COL1A2 COL3A1 COL1A1	Extracellular matrix organization
HP:0001622	0.0427188390613	0.375	COL1A2 COL3A1 COL1A1	Premature birth
HP:0010299	0.0427341718023	0.25	COL1A2 COL1A1	Abnormal dentin morphology
GO:0030199	0.0450022850424	0.375	COL1A2 COL3A1 COL1A1	collagen fibril organization
HP:0000978	0.0473312001068	0.375	COL1A2 COL3A1 COL1A1	Bruising susceptibility
HP:0025323	0.0473312001068	0.375	COL1A2 COL3A1 COL1A1	Abnormal arterial physiology

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
COL1A1	COL1A2	0.998	0.616	bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only
KLF15	COL3A1	0.997		bioplex3_WMM bioplex3_HCT116 WMM_only
TESPA1	COL3A1	0.997		bioplex3_WMM bioplex3_HCT116 WMM_only
TMEM44	COL3A1	0.996		bioplex3_WMM bioplex3_HCT116 WMM_only
CBLL2	COL1A2	0.993		bioplex3_WMM bioplex3_HCT116 WMM_only
TMEM44	COL1A2	0.984		bioplex3_WMM bioplex3_HCT116 WMM_only
COL1A1	KLF15	0.974		bioplex3_WMM bioplex3_HCT116 WMM_only
UBXN11	COL1A1	0.972		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TMEM44	COL1A1	0.972		bioplex3_WMM bioplex3_HCT116 WMM_only
CBLL2	COL1A1	0.962		bioplex3_WMM bioplex3_HCT116 WMM_only
COL1A1	TESPA1	0.962		bioplex3_WMM bioplex3_HCT116 WMM_only
COL1A1	COL3A1	0.94	0.530653061224	bioplex_WMM bioplex3_WMM WMM_only
COL1A2	COL3A1	0.828	0.464	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
KLF15	huMAP3_02820.1 huMAP3_08965.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10652.1 huMAP3_13382.1 huMAP3_14070.1 huMAP3_15229.1
UBXN11	huMAP3_02069.1 huMAP3_02141.1 huMAP3_04848.1 huMAP3_09231.1 huMAP3_10652.1 huMAP3_10780.1 huMAP3_14070.1
TMEM44	huMAP3_00943.1 huMAP3_10780.1 huMAP3_14070.1
TESPA1	huMAP3_02194.1 huMAP3_07657.1 huMAP3_08965.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_14070.1
COL1A2	huMAP3_02069.1 huMAP3_02141.1 huMAP3_06460.1 huMAP3_07562.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10652.1 huMAP3_10780.1 huMAP3_14070.1
COL3A1	huMAP3_02820.1 huMAP3_08354.1 huMAP3_08965.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10555.1 huMAP3_10652.1 huMAP3_13382.1 huMAP3_14070.1 huMAP3_15229.1
CBLL2	huMAP3_02069.1 huMAP3_02442.1 huMAP3_05851.1 huMAP3_06460.1 huMAP3_07814.1 huMAP3_08727.1 huMAP3_09523.1 huMAP3_09601.1 huMAP3_09606.1 huMAP3_09722.1 huMAP3_10021.1 huMAP3_10401.1 huMAP3_10652.1 huMAP3_12733.1 huMAP3_13681.1 huMAP3_14070.1
COL1A1	huMAP3_02069.1 huMAP3_02141.1 huMAP3_06460.1 huMAP3_07562.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10652.1 huMAP3_10780.1 huMAP3_14070.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14070.1