hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14074.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SH3GL1 | Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) | 5 | UniProt NCBI |
| HTR3C | 5-hydroxytryptamine receptor 3C (5-HT3-C) (5-HT3C) (Serotonin receptor 3C) | 5 | UniProt NCBI |
| SH3GL2 | Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) | 5 | UniProt NCBI |
| PRR5-ARHGAP8 | PRR5-ARHGAP8 readthrough | 2 | UniProt NCBI |
| TMEM104 | Transmembrane protein 104 | 3 | UniProt NCBI |
| SH3GL3 | Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) | 5 | UniProt NCBI |
| ARHGAP8 | Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8875360 | 4.73568218926e-06 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | InlB-mediated entry of Listeria monocytogenes into host cell |
| REAC:R-HSA-8876384 | 1.25938591632e-05 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | Listeria monocytogenes entry into host cells |
| REAC:R-HSA-6807004 | 1.48132609528e-05 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | Negative regulation of MET activity |
| REAC:R-HSA-182971 | 3.79530741097e-05 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | EGFR downregulation |
| GO:0016191 | 6.72425931667e-05 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | synaptic vesicle uncoating |
| GO:0072318 | 0.000117650375223 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | clathrin coat disassembly |
| REAC:R-HSA-177929 | 0.000171246735353 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | Signaling by EGFR |
| GO:0072319 | 0.0001882019462 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | vesicle uncoating |
| REAC:R-HSA-9824439 | 0.000419050615628 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | Bacterial Infection Pathways |
| REAC:R-HSA-6806834 | 0.000673985363387 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | Signaling by MET |
| REAC:R-HSA-8856825 | 0.00171545675339 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8856828 | 0.00497654929975 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | Clathrin-mediated endocytosis |
| KEGG:04144 | 0.00679381427833 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | Endocytosis |
| GO:0048488 | 0.0473277551461 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | synaptic vesicle endocytosis |
| GO:0140238 | 0.0473277551461 | 0.428571428571 | SH3GL3 SH3GL1 SH3GL2 | presynaptic endocytosis |
| CORUM:2029 | 0.0499958217778 | 0.142857142857 | ARHGAP8 | BNIP2-ARHGAP8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SH3GL1 | SH3GL3 | 1.0 | 0.194 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SH3GL2 | SH3GL3 | 1.0 | 0.206 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SH3GL1 | SH3GL2 | 1.0 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| TMEM104 | HTR3C | 0.961 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARHGAP8 | HTR3C | 0.88 | bioplex () bioplex_WMM bioplex3_WMM | |
| SH3GL3 | ARHGAP8 | 0.839 | bioplex () bioplex_WMM bioplex3_WMM | |
| SH3GL2 | ARHGAP8 | 0.763 | bioplex () bioplex_WMM bioplex3_WMM | |
| SH3GL3 | HTR3C | 0.513 | bioplex_WMM bioplex3_WMM WMM_only | |
| SH3GL1 | ARHGAP8 | 0.485 | bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| SH3GL2 | HTR3C | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | |
| SH3GL1 | HTR3C | 0.128 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes