hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14075.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS54 | Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) | 5 | UniProt NCBI |
| UBFD1 | Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding protein homolog) | 3 | UniProt NCBI |
| UFL1 | E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Multiple alpha-helix protein located at ER) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1) | 5 | UniProt NCBI |
| UFM1 | Ubiquitin-fold modifier 1 | 5 | UniProt NCBI |
| TXNDC2 | Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) | 5 | UniProt NCBI |
| OR6T1 | Olfactory receptor 6T1 (Olfactory receptor OR11-277) | 3 | UniProt NCBI |
| CDK5RAP3 | CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27) | 5 | UniProt NCBI |
| DDRGK1 | DDRGK domain-containing protein 1 (Dashurin) (UFM1-binding and PCI domain-containing protein 1) | 5 | UniProt NCBI |
| UFC1 | Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) | 5 | UniProt NCBI |
| UBA5 | Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0071569 | 7.7655937714e-16 | 0.6 | DDRGK1 UFL1 CDK5RAP3 UFC1 UBA5 UFM1 | protein ufmylation |
| GO:1990564 | 2.2691065e-12 | 0.5 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | protein polyufmylation |
| GO:1990592 | 2.2691065e-12 | 0.5 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | protein K69-linked ufmylation |
| GO:0061709 | 1.39932395176e-08 | 0.5 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | reticulophagy |
| GO:0034976 | 1.64815907334e-05 | 0.6 | DDRGK1 UFL1 CDK5RAP3 UFC1 UBA5 UFM1 | response to endoplasmic reticulum stress |
| GO:0033146 | 4.86250232062e-05 | 0.4 | UFM1 UBA5 UFL1 DDRGK1 | regulation of intracellular estrogen receptor signaling pathway |
| GO:0030520 | 0.000449289899845 | 0.4 | UFM1 UBA5 UFL1 DDRGK1 | intracellular estrogen receptor signaling pathway |
| GO:1903008 | 0.00104888708432 | 0.5 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | organelle disassembly |
| GO:0033143 | 0.00159218033758 | 0.4 | UFM1 UBA5 UFL1 DDRGK1 | regulation of intracellular steroid hormone receptor signaling pathway |
| GO:0022411 | 0.00423303735962 | 0.6 | DDRGK1 UFL1 CDK5RAP3 UFC1 UBA5 UFM1 | cellular component disassembly |
| GO:0030518 | 0.0156676066902 | 0.4 | UFM1 UBA5 UFL1 DDRGK1 | intracellular steroid hormone receptor signaling pathway |
| GO:0043401 | 0.0170719729259 | 0.4 | UFM1 UBA5 UFL1 DDRGK1 | steroid hormone mediated signaling pathway |
| GO:0071568 | 0.0210690324038 | 0.2 | UFC1 UFL1 | UFM1 transferase activity |
| GO:0016236 | 0.0255897714314 | 0.5 | UFM1 UBA5 UFC1 UFL1 DDRGK1 | macroautophagy |
| GO:0032446 | 0.0378180251524 | 0.6 | DDRGK1 UFL1 CDK5RAP3 UFC1 UBA5 UFM1 | protein modification by small protein conjugation |
| GO:0071383 | 0.0408402686151 | 0.4 | UFM1 UBA5 UFL1 DDRGK1 | cellular response to steroid hormone stimulus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UFL1 | CDK5RAP3 | 1.0 | 0.946 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| DDRGK1 | CDK5RAP3 | 1.0 | 0.934 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| UFL1 | DDRGK1 | 1.0 | 0.94 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| UFM1 | UBA5 | 0.999 | 0.154 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| UFL1 | UFM1 | 0.998 | 0.214 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () |
| DDRGK1 | UFM1 | 0.994 | 0.128 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DDRGK1 | UFC1 | 0.994 | 0.28 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| UFC1 | UBA5 | 0.993 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UFL1 | UFC1 | 0.989 | 0.104 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| UFM1 | CDK5RAP3 | 0.989 | 0.156 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| UFM1 | UFC1 | 0.97 | 0.168 | hein_WMM bioplex_WMM bioplex3_WMM fraction |
| UFL1 | VPS54 | 0.959 | 0.096 | hein_WMM bioplex3_WMM hein () fraction |
| UFM1 | UBFD1 | 0.93 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| VPS54 | CDK5RAP3 | 0.915 | 0.114 | hein_WMM bioplex3_WMM gupta_WMM WMM_only |
| UFC1 | UBFD1 | 0.911 | 0.09 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| CDK5RAP3 | UFC1 | 0.903 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VPS54 | TXNDC2 | 0.898 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| OR6T1 | CDK5RAP3 | 0.865 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| OR6T1 | DDRGK1 | 0.733 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| DDRGK1 | UBFD1 | 0.591 | 0.293540641312 | hein_WMM youn_WMM WMM_only |
| OR6T1 | UFL1 | 0.499 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| VPS54 | UFC1 | 0.255 | 0.108 | hein_WMM fraction |
| VPS54 | UFM1 | 0.248 | 0.092 | hein_WMM WMM_only |
| VPS54 | UBFD1 | 0.232 | 0.1 | hein_WMM WMM_only |
| CDK5RAP3 | UBFD1 | 0.192 | 0.02 | hein_WMM WMM_only |
| DDRGK1 | VPS54 | 0.172 | 0.108 | hein_WMM gupta_WMM WMM_only |
| UFL1 | UBFD1 | 0.137 | 0.03 | hein_WMM youn_WMM hein () gupta_WMM |
| CDK5RAP3 | UBA5 | 0.081 | 0.036 | bioplex3_WMM WMM_only |
| UFL1 | UBA5 | 0.053 | 0.112 | bioplex3_WMM WMM_only |
| VPS54 | UBA5 | 0.038 | 0.1 | fraction |
| DDRGK1 | UBA5 | 0.007 | 0.166 | fraction |
Related Complexes