List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_14077.1

Confidence: Medium   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
CRY1	Cryptochrome-1	5	UniProt   NCBI
PER1	Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)	5	UniProt   NCBI
GAPVD1	GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)	5	UniProt   NCBI
FAM110C	Protein FAM110C	5	UniProt   NCBI
PER3	Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3)	5	UniProt   NCBI
HNRNPA1L2	Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2)	3	UniProt   NCBI
CRY2	Cryptochrome-2	5	UniProt   NCBI
SNX22	Sorting nexin-22	4	UniProt   NCBI
ZNF618	Zinc finger protein 618	5	UniProt   NCBI
FBXL3	F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)	5	UniProt   NCBI
SNX24	Sorting nexin-24	3	UniProt   NCBI
PER2	Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)	5	UniProt   NCBI
CSNK1D	Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)	5	UniProt   NCBI
CSNK1E	Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04710	1.88195603688e-17	0.571428571429	FBXL3 CRY1 CRY2 PER2 PER1 PER3 CSNK1E CSNK1D	Circadian rhythm
WP:WP3298	1.24826270497e-14	0.5	CSNK1D CRY1 CRY2 PER2 PER1 PER3 CSNK1E	Melatonin metabolism and effects
REAC:R-HSA-400253	1.45702481981e-11	0.5	CRY2 CSNK1D PER2 CRY1 PER1 CSNK1E FBXL3	Circadian Clock
WP:WP3594	5.44407445913e-11	0.571428571429	FBXL3 CRY1 CRY2 PER2 PER1 PER3 CSNK1E CSNK1D	Circadian rhythm genes
GO:0042752	1.01083958307e-10	0.571428571429	FBXL3 CRY1 CRY2 PER2 PER1 PER3 CSNK1E CSNK1D	regulation of circadian rhythm
GO:0043153	8.22359366445e-10	0.428571428571	FBXL3 CRY1 CRY2 PER2 PER1 PER3	entrainment of circadian clock by photoperiod
GO:0009648	1.11208119806e-09	0.428571428571	FBXL3 CRY1 CRY2 PER2 PER1 PER3	photoperiodism
GO:0009649	1.94918693799e-09	0.428571428571	FBXL3 CRY1 CRY2 PER2 PER1 PER3	entrainment of circadian clock
GO:0032922	2.02974183426e-09	0.5	CSNK1D CRY1 CRY2 PER2 PER1 PER3 CSNK1E	circadian regulation of gene expression
GO:0007623	5.12747887661e-09	0.571428571429	FBXL3 CRY1 CRY2 PER2 PER1 PER3 CSNK1E CSNK1D	circadian rhythm
GO:0048511	1.45422226115e-08	0.571428571429	FBXL3 CRY1 CRY2 PER2 PER1 PER3 CSNK1E CSNK1D	rhythmic process
HP:0031873	2.97599495694e-06	0.214285714286	PER3 PER2 CSNK1D	Early chronotype
WP:WP410	6.09278426493e-06	0.285714285714	PER1 PER2 CRY1 CRY2	Exercise induced circadian regulation
HP:0006979	2.88484729778e-05	0.285714285714	PER3 CSNK1D FBXL3 PER2	Sleep-wake cycle disturbance
CORUM:2772	0.000266552996475	0.142857142857	CRY1 FBXL3	Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3)
CORUM:2773	0.000266552996475	0.142857142857	CRY2 FBXL3	Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3)
GO:0009416	0.000523576889264	0.428571428571	FBXL3 CRY1 CRY2 PER2 PER1 PER3	response to light stimulus
GO:2000323	0.000698569295426	0.214285714286	PER1 CRY1 CRY2	negative regulation of glucocorticoid receptor signaling pathway
GO:0042754	0.00122180600483	0.214285714286	PER2 CRY1 CRY2	negative regulation of circadian rhythm
GO:2000322	0.00122180600483	0.214285714286	PER1 CRY1 CRY2	regulation of glucocorticoid receptor signaling pathway
KEGG:04713	0.00232669214737	0.214285714286	PER1 PER2 PER3	Circadian entrainment
GO:0009314	0.00372173917427	0.428571428571	FBXL3 CRY1 CRY2 PER2 PER1 PER3	response to radiation
GO:0031958	0.00574694403184	0.214285714286	PER1 CRY1 CRY2	corticosteroid receptor signaling pathway
GO:0042921	0.00574694403184	0.214285714286	PER1 CRY1 CRY2	glucocorticoid receptor signaling pathway
HP:0002360	0.0328940674356	0.357142857143	PER3 CSNK1D PER2 CRY1 FBXL3	Sleep abnormality
WP:WP5381	0.0337822111661	0.214285714286	PER1 CRY1 CRY2	Smith Magenis and Potocki Lupski syndrome copy number variation
GO:0009882	0.0426062655276	0.142857142857	CRY1 CRY2	blue light photoreceptor activity
GO:0009785	0.0426062655276	0.142857142857	CRY1 CRY2	blue light signaling pathway
GO:0071483	0.0426062655276	0.142857142857	CRY1 CRY2	cellular response to blue light
KEGG:04340	0.0458275167467	0.142857142857	CSNK1D CSNK1E	Hedgehog signaling pathway



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
CRY2	CRY1	1.0	0.048
CSNK1E	PER1	1.0	0.1
SNX24	SNX22	1.0
SNX24	GAPVD1	1.0
PER1	CRY1	1.0	0.08
CRY2	PER1	0.999	0.124
CSNK1D	PER1	0.999	0.15
CRY2	CSNK1E	0.999	0.1176
CSNK1E	PER2	0.999
CSNK1D	PER2	0.999
PER2	CRY1	0.999
CSNK1E	CRY1	0.999	0.094
CSNK1D	GAPVD1	0.998
CRY2	PER2	0.998
PER2	PER1	0.998
CSNK1D	SNX24	0.998	0.084
FBXL3	CRY2	0.997
FBXL3	CRY1	0.997
CSNK1D	CSNK1E	0.997	0.28
PER1	PER3	0.997
CSNK1E	SNX24	0.996	0.084
CSNK1D	CRY1	0.996	0.196
ZNF618	SNX24	0.994
CSNK1E	GAPVD1	0.99
CRY2	CSNK1D	0.989	0.258
CRY2	PER3	0.984
PER2	GAPVD1	0.984
ZNF618	GAPVD1	0.981
CSNK1D	SNX22	0.98
SNX22	GAPVD1	0.979
CSNK1E	FAM110C	0.97
ZNF618	CSNK1D	0.967
ZNF618	CSNK1E	0.964
ZNF618	PER2	0.952
HNRNPA1L2	CRY1	0.91	0.252
FBXL3	PER2	0.903
FAM110C	SNX24	0.902
FAM110C	PER2	0.902
FAM110C	GAPVD1	0.892
PER2	PER3	0.77
ZNF618	SNX22	0.763
CRY2	GAPVD1	0.756
PER2	SNX24	0.737
FBXL3	PER1	0.727
CRY2	FAM110C	0.703
FAM110C	CRY1	0.676
PER1	SNX24	0.608	0.066
CRY1	GAPVD1	0.605
FBXL3	CSNK1E	0.581
ZNF618	PER1	0.528
PER3	CRY1	0.49
FBXL3	CSNK1D	0.445
FAM110C	PER1	0.437
PER1	GAPVD1	0.377
HNRNPA1L2	PER2	0.335
CSNK1E	SNX22	0.233
SNX24	CRY1	0.232	0.102
CSNK1E	PER3	0.222
CRY2	ZNF618	0.218
CRY2	SNX24	0.206	0.068
ZNF618	CRY1	0.201
PER1	SNX22	0.177
CSNK1D	PER3	0.177
PER2	SNX22	0.172
FBXL3	HNRNPA1L2	0.163
ZNF618	FAM110C	0.146
SNX22	CRY1	0.143
CRY2	SNX22	0.143
HNRNPA1L2	PER1	0.1	0.148
CSNK1D	HNRNPA1L2	0.046	0.242
CSNK1D	FAM110C	0.043
HNRNPA1L2	CSNK1E	0.038	0.35
CRY2	HNRNPA1L2	0.026	0.730772694551
HNRNPA1L2	SNX24	0.012	0.138
HNRNPA1L2	GAPVD1	0.001





Related Complexes

Genename	Complexes
CRY1	huMAP3_05691.1 huMAP3_10653.1 huMAP3_14077.1 huMAP3_14497.1
PER1	huMAP3_03840.1 huMAP3_09402.1 huMAP3_10653.1 huMAP3_12394.1 huMAP3_14077.1 huMAP3_14497.1
GAPVD1	huMAP3_06452.1 huMAP3_08629.1 huMAP3_10653.1 huMAP3_14077.1 huMAP3_14414.1 huMAP3_14497.1
FAM110C	huMAP3_02757.1 huMAP3_06274.1 huMAP3_08780.1 huMAP3_09402.1 huMAP3_10653.1 huMAP3_14077.1 huMAP3_14414.1 huMAP3_14497.1
PER3	huMAP3_03840.1 huMAP3_04192.1 huMAP3_05691.1 huMAP3_10653.1 huMAP3_11401.1 huMAP3_14077.1 huMAP3_14497.1
HNRNPA1L2	huMAP3_02013.1 huMAP3_10595.1 huMAP3_10659.1 huMAP3_10937.1 huMAP3_14077.1 huMAP3_14497.1 huMAP3_14523.1
CRY2	huMAP3_01377.1 huMAP3_05691.1 huMAP3_10653.1 huMAP3_14077.1 huMAP3_14497.1
SNX22	huMAP3_04834.1 huMAP3_07641.1 huMAP3_10653.1 huMAP3_12533.1 huMAP3_14077.1 huMAP3_14363.1 huMAP3_14414.1 huMAP3_14497.1
ZNF618	huMAP3_01981.1 huMAP3_07565.1 huMAP3_08629.1 huMAP3_10653.1 huMAP3_14077.1 huMAP3_14414.1 huMAP3_14497.1
FBXL3	huMAP3_01377.1 huMAP3_05691.1 huMAP3_10653.1 huMAP3_11774.1 huMAP3_12503.1 huMAP3_13353.1 huMAP3_14077.1 huMAP3_14497.1 huMAP3_15251.1
SNX24	huMAP3_04834.1 huMAP3_07641.1 huMAP3_10653.1 huMAP3_14077.1 huMAP3_14414.1 huMAP3_14497.1
PER2	huMAP3_02757.1 huMAP3_07565.1 huMAP3_08629.1 huMAP3_10653.1 huMAP3_14077.1 huMAP3_14414.1 huMAP3_14497.1
CSNK1D	huMAP3_01981.1 huMAP3_07565.1 huMAP3_08629.1 huMAP3_10653.1 huMAP3_14077.1 huMAP3_14497.1
CSNK1E	huMAP3_02757.1 huMAP3_06274.1 huMAP3_08780.1 huMAP3_09402.1 huMAP3_10653.1 huMAP3_14077.1 huMAP3_14497.1