hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14088.1
Complex Portal: CPX-15099
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM175 | Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175) (hTMEM175) | 5 | UniProt NCBI |
| HCN3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | 5 | UniProt NCBI |
| BVES | Blood vessel epicardial substance (hBVES) (Popeye domain-containing protein 1) (Popeye protein 1) | 5 | UniProt NCBI |
| CACNA1H | Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) | 5 | UniProt NCBI |
| ATP11B | Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) | 5 | UniProt NCBI |
| HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 5 | UniProt NCBI |
| DAGLA | Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha) | 5 | UniProt NCBI |
| JAGN1 | Protein jagunal homolog 1 | 5 | UniProt NCBI |
| ANO10 | Anoctamin-10 (Transmembrane protein 16K) | 5 | UniProt NCBI |
| UTS2R | Urotensin-2 receptor (UR-2-R) (G-protein coupled receptor 14) (Urotensin II receptor) (UR-II-R) | 5 | UniProt NCBI |
| TTYH1 | Protein tweety homolog 1 (hTTY1) | 5 | UniProt NCBI |
| HCN2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) | 5 | UniProt NCBI |
| CCDC167 | Coiled-coil domain-containing protein 167 | 5 | UniProt NCBI |
| DNAJC4 | DnaJ homolog subfamily C member 4 (DnaJ-like protein HSPF2) (Multiple endocrine neoplasia type 1 candidate protein number 18) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1296061 | 7.85796421216e-07 | 0.214285714286 | HCN3 HCN4 HCN2 | HCN channels |
| GO:0015075 | 8.26439710138e-05 | 0.571428571429 | HCN4 ANO10 ATP11B HCN2 TTYH1 HCN3 TMEM175 CACNA1H | monoatomic ion transmembrane transporter activity |
| GO:0005216 | 8.69605369509e-05 | 0.5 | HCN4 ANO10 HCN2 TTYH1 HCN3 TMEM175 CACNA1H | monoatomic ion channel activity |
| GO:0098855 | 0.000139871762976 | 0.214285714286 | HCN3 HCN4 HCN2 | HCN channel complex |
| GO:0034220 | 0.000146049196204 | 0.571428571429 | HCN4 ANO10 ATP11B HCN2 TTYH1 HCN3 TMEM175 CACNA1H | monoatomic ion transmembrane transport |
| GO:0015267 | 0.000180073873834 | 0.5 | HCN4 ANO10 HCN2 TTYH1 HCN3 TMEM175 CACNA1H | channel activity |
| GO:0022803 | 0.000184402715151 | 0.5 | HCN4 ANO10 HCN2 TTYH1 HCN3 TMEM175 CACNA1H | passive transmembrane transporter activity |
| KEGG:04929 | 0.000539303141978 | 0.214285714286 | HCN3 CACNA1H HCN2 | GnRH secretion |
| GO:0005261 | 0.0008350940742 | 0.428571428571 | HCN4 ANO10 HCN2 HCN3 TMEM175 CACNA1H | monoatomic cation channel activity |
| GO:0008324 | 0.000927676897603 | 0.5 | HCN4 ANO10 HCN2 TTYH1 HCN3 TMEM175 CACNA1H | monoatomic cation transmembrane transporter activity |
| GO:0006811 | 0.00121642000208 | 0.571428571429 | HCN4 ANO10 ATP11B HCN2 TTYH1 HCN3 TMEM175 CACNA1H | monoatomic ion transport |
| GO:0015318 | 0.00188132834775 | 0.5 | HCN4 ANO10 HCN2 TTYH1 HCN3 TMEM175 CACNA1H | inorganic molecular entity transmembrane transporter activity |
| WP:WP1992 | 0.00207991888463 | 0.142857142857 | HCN4 HCN2 | Genes targeted by miRNAs in adipocytes |
| GO:0022857 | 0.00282834851232 | 0.571428571429 | HCN4 ANO10 ATP11B HCN2 TTYH1 HCN3 TMEM175 CACNA1H | transmembrane transporter activity |
| GO:0046873 | 0.00389700862305 | 0.428571428571 | HCN4 HCN2 TTYH1 HCN3 TMEM175 CACNA1H | metal ion transmembrane transporter activity |
| GO:0055085 | 0.0064789119026 | 0.571428571429 | HCN4 ANO10 ATP11B HCN2 TTYH1 HCN3 TMEM175 CACNA1H | transmembrane transport |
| GO:0005215 | 0.00681182491667 | 0.571428571429 | HCN4 ANO10 ATP11B HCN2 TTYH1 HCN3 TMEM175 CACNA1H | transporter activity |
| REAC:R-HSA-1296071 | 0.00868002537299 | 0.214285714286 | HCN3 HCN4 HCN2 | Potassium Channels |
| GO:0006812 | 0.0117725190576 | 0.5 | HCN4 ANO10 HCN2 TTYH1 HCN3 TMEM175 CACNA1H | monoatomic cation transport |
| GO:0005267 | 0.0133222465465 | 0.285714285714 | TMEM175 HCN4 HCN2 HCN3 | potassium channel activity |
| GO:0005248 | 0.0158118674804 | 0.214285714286 | HCN3 HCN4 HCN2 | voltage-gated sodium channel activity |
| GO:0022890 | 0.0194586963806 | 0.428571428571 | HCN4 HCN2 TTYH1 HCN3 TMEM175 CACNA1H | inorganic cation transmembrane transporter activity |
| KEGG:04024 | 0.0229942686538 | 0.214285714286 | BVES HCN2 HCN4 | cAMP signaling pathway |
| GO:0022836 | 0.0232009116009 | 0.357142857143 | HCN3 ANO10 CACNA1H HCN2 HCN4 | gated channel activity |
| GO:0042391 | 0.043422212207 | 0.357142857143 | HCN3 HCN4 BVES HCN2 CACNA1H | regulation of membrane potential |
| GO:0022843 | 0.0441393506231 | 0.285714285714 | HCN3 CACNA1H HCN2 HCN4 | voltage-gated monoatomic cation channel activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| ATP11B | TTYH1 | 0.988 | ||
| TMEM175 | TTYH1 | 0.988 | ||
| DNAJC4 | TTYH1 | 0.986 | ||
| HCN4 | HCN2 | 0.985 | ||
| TTYH1 | UTS2R | 0.984 | ||
| JAGN1 | TTYH1 | 0.983 | ||
| CCDC167 | TTYH1 | 0.982 | ||
| HCN4 | HCN3 | 0.98 |
structurally_consistent (dimer)
|
|
| CACNA1H | TTYH1 | 0.977 | ||
| ANO10 | TTYH1 | 0.973 | ||
| TTYH1 | BVES | 0.971 | ||
| DAGLA | TTYH1 | 0.971 | ||
| HCN3 | TTYH1 | 0.967 | ||
| HCN2 | TTYH1 | 0.915 | ||
| JAGN1 | DNAJC4 | 0.415 | ||
| JAGN1 | ATP11B | 0.415 | 0.038 | |
| JAGN1 | CACNA1H | 0.415 | ||
| ANO10 | DNAJC4 | 0.415 | ||
| HCN3 | CCDC167 | 0.415 | ||
| HCN2 | ATP11B | 0.415 | ||
| HCN3 | ATP11B | 0.415 | ||
| DNAJC4 | CACNA1H | 0.415 | ||
| HCN3 | DNAJC4 | 0.415 | ||
| DNAJC4 | BVES | 0.415 | ||
| ATP11B | BVES | 0.415 | ||
| ANO10 | CCDC167 | 0.415 | 0.064 | |
| CACNA1H | BVES | 0.415 | ||
| ATP11B | CCDC167 | 0.415 | 0.053 | |
| HCN2 | CACNA1H | 0.415 | ||
| CACNA1H | ATP11B | 0.415 | ||
| HCN3 | CACNA1H | 0.415 | ||
| ANO10 | HCN2 | 0.415 | ||
| DNAJC4 | CCDC167 | 0.415 | ||
| TMEM175 | HCN2 | 0.415 | ||
| ANO10 | HCN3 | 0.415 | ||
| TMEM175 | CACNA1H | 0.415 | ||
| ANO10 | CACNA1H | 0.415 | ||
| DNAJC4 | ATP11B | 0.415 | ||
| CACNA1H | CCDC167 | 0.415 | ||
| TMEM175 | DNAJC4 | 0.415 | ||
| HCN2 | BVES | 0.415 | ||
| HCN2 | DNAJC4 | 0.415 | ||
| TMEM175 | ATP11B | 0.415 | ||
| HCN2 | CCDC167 | 0.415 | ||
| JAGN1 | HCN2 | 0.415 | ||
| HCN2 | HCN3 | 0.391 | ||
| HCN2 | UTS2R | 0.278 | ||
| DAGLA | DNAJC4 | 0.278 | ||
| CACNA1H | UTS2R | 0.278 | ||
| DAGLA | CACNA1H | 0.278 | ||
| ATP11B | UTS2R | 0.278 | ||
| DAGLA | ATP11B | 0.278 | ||
| DAGLA | HCN2 | 0.278 | ||
| DNAJC4 | UTS2R | 0.278 | ||
| TMEM175 | CCDC167 | 0.274 | ||
| TMEM175 | HCN3 | 0.274 | ||
| JAGN1 | HCN3 | 0.274 | ||
| HCN3 | BVES | 0.274 | ||
| JAGN1 | CCDC167 | 0.274 | 0.022 | |
| CCDC167 | BVES | 0.274 | ||
| ANO10 | BVES | 0.274 | ||
| TMEM175 | ANO10 | 0.274 | ||
| DAGLA | CCDC167 | 0.25 | ||
| ANO10 | UTS2R | 0.25 | ||
| HCN3 | UTS2R | 0.25 | ||
| CCDC167 | UTS2R | 0.25 | ||
| DAGLA | ANO10 | 0.25 | ||
| DAGLA | HCN3 | 0.25 | ||
| ANO10 | ATP11B | 0.232 | 0.058 | |
| TMEM175 | JAGN1 | 0.21 | ||
| JAGN1 | BVES | 0.21 | ||
| TMEM175 | BVES | 0.21 | ||
| JAGN1 | ANO10 | 0.121 | 0.036 | |
| BVES | UTS2R | 0.113 | ||
| DAGLA | JAGN1 | 0.113 | ||
| TMEM175 | DAGLA | 0.113 | ||
| TMEM175 | UTS2R | 0.113 | ||
| JAGN1 | UTS2R | 0.113 | ||
| DAGLA | BVES | 0.113 | ||
| DAGLA | UTS2R | 0.095 |
Related Complexes