hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14109.1
Complex Portal: CPX-18166
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMAD5 | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | 5 | UniProt NCBI |
| SP110 | Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) | 5 | UniProt NCBI |
| SMURF2 | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) | 5 | UniProt NCBI |
| SMAD1 | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | 5 | UniProt NCBI |
| SMURF1 | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-201451 | 5.39727369539e-09 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | Signaling by BMP |
| KEGG:04350 | 2.83024199204e-07 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | TGF-beta signaling pathway |
| REAC:R-HSA-9006936 | 2.27611882554e-06 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | Signaling by TGFB family members |
| GO:0046332 | 4.81842507515e-05 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | SMAD binding |
| WP:WP3876 | 0.000264396631677 | 0.4 | SMAD5 SMAD1 | BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation |
| WP:WP1425 | 0.000264396631677 | 0.4 | SMAD1 SMURF1 | Bone morphogenic protein signaling and regulation |
| GO:0030509 | 0.000319733015871 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | BMP signaling pathway |
| GO:0071772 | 0.000365836607157 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | response to BMP |
| GO:0071773 | 0.000365836607157 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | cellular response to BMP stimulus |
| GO:0070411 | 0.000436807598019 | 0.6 | SMAD5 SMURF1 SMAD1 | I-SMAD binding |
| WP:WP3927 | 0.000798299856649 | 0.4 | SMAD5 SMAD1 | BMP signaling in eyelid development |
| WP:WP2895 | 0.00123199381981 | 0.4 | SMAD5 SMAD1 | Differentiation of white and brown adipocyte |
| GO:0007179 | 0.00257382782381 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | transforming growth factor beta receptor signaling pathway |
| WP:WP4331 | 0.00290547066497 | 0.4 | SMAD5 SMAD1 | Neovascularisation processes |
| REAC:R-HSA-2173788 | 0.00383489202506 | 0.4 | SMURF1 SMURF2 | Downregulation of TGF-beta receptor signaling |
| WP:WP4249 | 0.00389862536801 | 0.4 | SMURF1 SMURF2 | Hedgehog signaling pathway |
| GO:0071560 | 0.00437843642246 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | cellular response to transforming growth factor beta stimulus |
| KEGG:04340 | 0.00447375439216 | 0.4 | SMURF1 SMURF2 | Hedgehog signaling pathway |
| GO:0071559 | 0.00492038984684 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | response to transforming growth factor beta |
| WP:WP560 | 0.00528162918062 | 0.4 | SMAD5 SMAD1 | TGF beta receptor signaling |
| WP:WP4816 | 0.00578890329638 | 0.4 | SMAD5 SMAD1 | TGF beta receptor signaling in skeletal dysplasias |
| WP:WP5352 | 0.00631928190743 | 0.4 | SMAD5 SMAD1 | 10q11 21q11 23 copy number variation syndrome |
| WP:WP5236 | 0.00631928190743 | 0.4 | SMAD5 SMAD1 | Markers of kidney cell lineage |
| REAC:R-HSA-2173789 | 0.0123986787504 | 0.4 | SMURF1 SMURF2 | TGF-beta receptor signaling activates SMADs |
| GO:0141091 | 0.0125732528527 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | transforming growth factor beta receptor superfamily signaling pathway |
| WP:WP5094 | 0.0128896073912 | 0.4 | SMAD5 SMAD1 | Orexin receptor pathway |
| WP:WP5205 | 0.0132783799217 | 0.4 | SMAD5 SMAD1 | Clock controlled autophagy in bone metabolism |
| GO:0007178 | 0.01554629601 | 0.8 | SMAD5 SMURF1 SMURF2 SMAD1 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| WP:WP5353 | 0.015731077008 | 0.4 | SMAD5 SMAD1 | A network map of Macrophage stimulating protein MSP signaling |
| KEGG:04520 | 0.0164241113683 | 0.4 | SMURF1 SMURF2 | Adherens junction |
| KEGG:04137 | 0.0213229262457 | 0.4 | SMURF1 SMURF2 | Mitophagy - animal |
| REAC:R-HSA-8941858 | 0.0215986811086 | 0.4 | SMURF1 SMURF2 | Regulation of RUNX3 expression and activity |
| WP:WP3931 | 0.0287269200827 | 0.4 | SMAD5 SMAD1 | Embryonic stem cell pluripotency pathways |
| REAC:R-HSA-4608870 | 0.0294410858888 | 0.4 | SMURF1 SMURF2 | Asymmetric localization of PCP proteins |
| WP:WP4787 | 0.0298851974032 | 0.4 | SMAD5 SMAD1 | Osteoblast differentiation and related diseases |
| KEGG:04550 | 0.0319348346673 | 0.4 | SMAD5 SMAD1 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04120 | 0.0403719343567 | 0.4 | SMURF1 SMURF2 | Ubiquitin mediated proteolysis |
| WP:WP366 | 0.0406395857275 | 0.4 | SMURF1 SMURF2 | TGF beta signaling pathway |
| REAC:R-HSA-5632684 | 0.0440242300692 | 0.4 | SMURF1 SMURF2 | Hedgehog 'on' state |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SMAD5 | SMURF2 | 0.974 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SMURF2 | SMURF1 | 0.969 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SMAD1 | SMURF2 | 0.966 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SP110 | SMURF2 | 0.904 | bioplex3_WMM WMM_only | ||
| SMAD1 | SMURF1 | 0.502 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD5 | SMURF1 | 0.32 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMAD5 | SMAD1 | 0.3 | 0.168 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes