hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14118.1

Complex Portal: CPX-11281

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
FAM83G	Protein FAM83G (Protein associated with SMAD1)	5	UniProt NCBI
IGFBP4	Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4)	5	UniProt NCBI
INHBE	Inhibin beta E chain (Activin beta-E chain)	4	UniProt NCBI
IRS2	Insulin receptor substrate 2 (IRS-2)	5	UniProt NCBI
SPRYD3	SPRY domain-containing protein 3	2	UniProt NCBI
HEY1	Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1)	5	UniProt NCBI
PARD3	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	5	UniProt NCBI
HDAC4	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	5	UniProt NCBI
MYCBP2	E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Protein associated with Myc)	5	UniProt NCBI
FBXO45	F-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45)	5	UniProt NCBI
TP53BP2	Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)	5	UniProt NCBI
RASSF8	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1)	4	UniProt NCBI
CS	Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)	5	UniProt NCBI
HDAC7	Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a)	5	UniProt NCBI
PRR36	Proline-rich protein 36	2	UniProt NCBI
FAM169A	Soluble lamin-associated protein of 75 kDa (SLAP75) (Protein FAM169A)	3	UniProt NCBI
FBXW7	F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-2122947	0.00303413678181	0.1875	HEY1 HDAC7 HDAC4	NOTCH1 Intracellular Domain Regulates Transcription
WP:WP4906	0.00338354586634	0.1875	FBXO45 MYCBP2 FBXW7	3q29 copy number variation syndrome
REAC:R-HSA-2894862	0.00495638650203	0.1875	HEY1 HDAC7 HDAC4	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REAC:R-HSA-2644606	0.00495638650203	0.1875	HEY1 HDAC7 HDAC4	Constitutive Signaling by NOTCH1 PEST Domain Mutants
REAC:R-HSA-2894858	0.00495638650203	0.1875	HEY1 HDAC7 HDAC4	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REAC:R-HSA-2644602	0.00495638650203	0.1875	HEY1 HDAC7 HDAC4	Signaling by NOTCH1 PEST Domain Mutants in Cancer
REAC:R-HSA-2644603	0.00495638650203	0.1875	HEY1 HDAC7 HDAC4	Signaling by NOTCH1 in Cancer
REAC:R-HSA-1980143	0.00985760715853	0.1875	HEY1 HDAC7 HDAC4	Signaling by NOTCH1
WP:WP3996	0.0465207903625	0.125	HDAC4 HDAC7	Ethanol effects on histone modifications
CORUM:57	0.0497620750785	0.0625	HDAC4	HDAC4-ERK2 complex
WP:WP3414	0.0499348849842	0.125	HDAC4 HDAC7	Initiation of transcription and translation elongation at the HIV 1 LTR

Edges

Protein 1	Protein 2	Score	ProteomeHD
RASSF8	TP53BP2	1.0	0.148
PARD3	RASSF8	1.0	0.116
FBXO45	CS	0.997	0.154
INHBE	FBXO45	0.997
FBXO45	MYCBP2	0.995	0.1
CS	MYCBP2	0.993	0.108
FBXO45	SPRYD3	0.992	0.124
SPRYD3	MYCBP2	0.989	0.146
HEY1	CS	0.989
FAM83G	HDAC7	0.987	0.066
FAM83G	HDAC4	0.987	0.07
HDAC4	HDAC7	0.985	0.078
HEY1	FBXO45	0.984
IRS2	MYCBP2	0.984	0.142
FAM83G	PARD3	0.984	0.062
HDAC4	RASSF8	0.983	0.126
HDAC4	IRS2	0.981	0.140666666667
HDAC7	IRS2	0.981	0.044
PARD3	HDAC4	0.98	0.106
PARD3	HDAC7	0.98	0.084
IGFBP4	SPRYD3	0.98	0.05
FAM83G	IRS2	0.979	0.098
RASSF8	HDAC7	0.978	0.104
PARD3	TP53BP2	0.977	0.09
HEY1	MYCBP2	0.975
HDAC4	MYCBP2	0.973	0.086
HDAC7	MYCBP2	0.973	0.05
HEY1	SPRYD3	0.971
IGFBP4	FBXO45	0.97	0.086
TP53BP2	SPRYD3	0.961	0.122
SPRYD3	CS	0.959	0.148
FAM83G	RASSF8	0.956	0.074
SPRYD3	IRS2	0.954	0.08
INHBE	SPRYD3	0.953
INHBE	FAM169A	0.95
FBXW7	PRR36	0.948
HDAC4	TP53BP2	0.946	0.144
HDAC7	TP53BP2	0.946	0.056
INHBE	CS	0.935
MYCBP2	FBXW7	0.933
HDAC7	FBXO45	0.933	0.066
HDAC4	FBXO45	0.933	0.136
FAM83G	FBXO45	0.933	0.08
FBXO45	IRS2	0.918	0.086
FBXO45	FBXW7	0.909
TP53BP2	IRS2	0.904	0.108
FAM83G	MYCBP2	0.901	0.106
HDAC7	SPRYD3	0.897	0.064
FAM83G	SPRYD3	0.897	0.058
HDAC4	SPRYD3	0.896	0.096
IGFBP4	CS	0.89	0.07
CS	FBXW7	0.868
INHBE	MYCBP2	0.84
TP53BP2	FBXO45	0.817	0.084
IGFBP4	MYCBP2	0.764	0.216
PARD3	IRS2	0.667	0.078
TP53BP2	MYCBP2	0.63	0.09
RASSF8	IRS2	0.585	0.182
FAM83G	TP53BP2	0.584	0.078
RASSF8	FBXO45	0.356	0.148
PARD3	FBXO45	0.356	0.038
MYCBP2	PRR36	0.244	0.1
CS	FAM169A	0.218	0.096
CS	PRR36	0.179	0.1
RASSF8	SPRYD3	0.156	0.084
PARD3	SPRYD3	0.156	0.062
FBXO45	PRR36	0.143	0.04
FBXO45	FAM169A	0.142	0.076
RASSF8	MYCBP2	0.135	0.088
MYCBP2	FAM169A	0.115	0.1
HDAC4	CS	0.079	0.202
PARD3	MYCBP2	0.053	0.06
SPRYD3	FAM169A	0.042	0.026
CS	IRS2	0.031	0.176
PARD3	CS	0.027	0.131514285714
TP53BP2	CS	0.026	0.096
HDAC7	CS	0.021	0.096
FAM83G	CS	0.018	0.092
RASSF8	CS	0.01	0.156
PARD3	FAM169A	0.005	0.06

Related Complexes

Genename	Complexes
FAM83G	huMAP3_00531.1 huMAP3_06269.1 huMAP3_09641.1 huMAP3_10898.1 huMAP3_14118.1
IGFBP4	huMAP3_02449.1 huMAP3_03816.1 huMAP3_07658.1 huMAP3_08066.1 huMAP3_09635.1 huMAP3_11188.1 huMAP3_11456.1 huMAP3_14118.1 huMAP3_14676.1
INHBE	huMAP3_00074.1 huMAP3_03816.1 huMAP3_09635.1 huMAP3_14118.1
IRS2	huMAP3_04537.1 huMAP3_07081.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_08092.1 huMAP3_09358.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10898.1 huMAP3_11629.1 huMAP3_12185.1 huMAP3_12897.1 huMAP3_14118.1
SPRYD3	huMAP3_03816.1 huMAP3_09635.1 huMAP3_14118.1
HEY1	huMAP3_03816.1 huMAP3_09635.1 huMAP3_14118.1
PARD3	huMAP3_00531.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_06269.1 huMAP3_07838.1 huMAP3_09641.1 huMAP3_09726.1 huMAP3_09810.1 huMAP3_10212.1 huMAP3_10898.1 huMAP3_12987.1 huMAP3_14118.1
HDAC4	huMAP3_00531.1 huMAP3_04537.1 huMAP3_06269.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09641.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10898.1 huMAP3_12897.1 huMAP3_14118.1
MYCBP2	huMAP3_04604.1 huMAP3_09635.1 huMAP3_11973.1 huMAP3_14118.1
FBXO45	huMAP3_03816.1 huMAP3_09635.1 huMAP3_14118.1
TP53BP2	huMAP3_01036.1 huMAP3_06304.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_10148.1 huMAP3_14118.1 huMAP3_14504.1
RASSF8	huMAP3_00531.1 huMAP3_01036.1 huMAP3_06269.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_09641.1 huMAP3_10148.1 huMAP3_10898.1 huMAP3_12886.1 huMAP3_14118.1
CS	huMAP3_03816.1 huMAP3_09635.1 huMAP3_14118.1
HDAC7	huMAP3_00531.1 huMAP3_06269.1 huMAP3_09641.1 huMAP3_10898.1 huMAP3_14118.1
PRR36	huMAP3_12702.1 huMAP3_13744.1 huMAP3_14118.1
FAM169A	huMAP3_14118.1
FBXW7	huMAP3_12702.1 huMAP3_14118.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14118.1

Complex Portal: CPX-11281