hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14123.1
Complex Portal: CPX-17991
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDST4 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 4) (NDST-4) (N-heparan sulfate sulfotransferase 4) (N-HSST 4) [Includes: Heparan sulfate N-deacetylase 4 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 4 (EC 2.8.2.-)] | 5 | UniProt NCBI |
| GAL3ST2 | Galactose-3-O-sulfotransferase 2 (Gal3ST-2) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 2) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 2) (Glycoprotein beta-Gal 3'-sulfotransferase 2) | 5 | UniProt NCBI |
| NDST3 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)] | 5 | UniProt NCBI |
| KCTD13 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (TNFAIP1-like protein) | 5 | UniProt NCBI |
| TPSB2 | Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II) | 5 | UniProt NCBI |
| LMF1 | Lipase maturation factor 1 (Transmembrane protein 112) | 5 | UniProt NCBI |
| CLGN | Calmegin | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP702 | 0.00108366806834 | 0.5 | NDST4 NDST3 GAL3ST2 | Metapathway biotransformation Phase I and II |
| KEGG:00534 | 0.00152145524258 | 0.333333333333 | NDST4 NDST3 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
| WP:WP5395 | 0.00703705758996 | 0.333333333333 | NDST4 NDST3 | Glycosaminoglycan synthesis in fibroblasts |
| REAC:R-HSA-2022928 | 0.00971370123257 | 0.333333333333 | NDST4 NDST3 | HS-GAG biosynthesis |
| GO:0008146 | 0.0188853212627 | 0.5 | NDST4 NDST3 GAL3ST2 | sulfotransferase activity |
| REAC:R-HSA-1638091 | 0.0313533174732 | 0.333333333333 | NDST4 NDST3 | Heparan sulfate/heparin (HS-GAG) metabolism |
| GO:0015016 | 0.042122686785 | 0.333333333333 | NDST4 NDST3 | [heparan sulfate]-glucosamine N-sulfotransferase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NDST3 | NDST4 | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NDST3 | KCTD13 | 0.972 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NDST3 | LMF1 | 0.912 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CLGN | LMF1 | 0.904 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| GAL3ST2 | CLGN | 0.897 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LMF1 | TPSB2 | 0.889 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| CLGN | NDST3 | 0.888 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CLGN | TPSB2 | 0.219 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| CLGN | NDST4 | 0.133 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NDST4 | KCTD13 | 0.055 | bioplex3_WMM WMM_only | ||
| GAL3ST2 | LMF1 | 0.04 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LMF1 | KCTD13 | 0.027 | bioplex3_WMM WMM_only | ||
| NDST4 | LMF1 | 0.026 | bioplex3_WMM WMM_only | ||
| CLGN | KCTD13 | 0.011 | bioplex3_WMM WMM_only |
Related Complexes