hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14140.1
Confidence: Medium  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
GABBR2 | Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) | 5 | UniProt   NCBI |
PCDH1 | Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) | 5 | UniProt   NCBI |
SLC2A13 | Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) | 5 | UniProt   NCBI |
NECTIN2 | Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112) | 5 | UniProt   NCBI |
ULBP1 | UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I) | 5 | UniProt   NCBI |
SLAMF8 | SLAM family member 8 (B-lymphocyte activator macrophage expressed) (BCM-like membrane protein) (CD antigen CD353) | 5 | UniProt   NCBI |
CEACAM21 | Carcinoembryonic antigen-related cell adhesion molecule 21 | 4 | UniProt   NCBI |
RAET1E | Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4) | 5 | UniProt   NCBI |
FCRL2 | Fc receptor-like protein 2 (FcR-like protein 2) (FcRL2) (Fc receptor homolog 2) (FcRH2) (IFGP family protein 4) (Immunoglobulin receptor translocation-associated protein 4) (SH2 domain-containing phosphatase anchor protein 1) (CD antigen CD307b) | 5 | UniProt   NCBI |
ULBP2 | UL16-binding protein 2 (ALCAN-alpha) (NKG2D ligand 2) (N2DL-2) (NKG2DL2) (Retinoic acid early transcript 1H) | 5 | UniProt   NCBI |
CD276 | CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276) | 5 | UniProt   NCBI |
HBD | Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) | 5 | UniProt   NCBI |
TNFSF9 | Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL) | 5 | UniProt   NCBI |
ULBP3 | UL16-binding protein 3 (ALCAN-gamma) (NKG2D ligand 3) (N2DL-3) (NKG2DL3) (Retinoic acid early transcript 1N) | 5 | UniProt   NCBI |
NCR3LG1 | Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6) | 5 | UniProt   NCBI |
ITFG1 | T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin) | 4 | UniProt   NCBI |
RYK | Tyrosine-protein kinase RYK (EC 2.7.10.1) | 5 | UniProt   NCBI |
PODXL2 | Podocalyxin-like protein 2 (Endoglycan) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  GO:0046703 | 1.20589885889e-06 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | natural killer cell lectin-like receptor binding |
  GO:0001916 | 1.07921902629e-05 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | positive regulation of T cell mediated cytotoxicity |
  GO:0001914 | 2.84232471362e-05 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | regulation of T cell mediated cytotoxicity |
  REAC:R-HSA-198933 | 2.86633365762e-05 | 0.277777777778 | ULBP1 ULBP3 NCR3LG1 NECTIN2 RAET1E | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
  GO:0001913 | 3.77876631458e-05 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | T cell mediated cytotoxicity |
  GO:0002484 | 5.71734151998e-05 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway |
  GO:0002486 | 5.71734151998e-05 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent |
  GO:0002476 | 7.99814110028e-05 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib |
  GO:0002428 | 7.99814110028e-05 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation of peptide antigen via MHC class Ib |
  GO:0042267 | 9.15006040948e-05 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | natural killer cell mediated cytotoxicity |
  GO:0002711 | 9.15006040948e-05 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | positive regulation of T cell mediated immunity |
  GO:0002228 | 0.000102582978506 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | natural killer cell mediated immunity |
  GO:0001912 | 0.000127953259819 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | positive regulation of leukocyte mediated cytotoxicity |
  GO:0009986 | 0.000155793804714 | 0.5 | NECTIN2 ULBP1 FCRL2 SLAMF8 CEACAM21 RAET1E ULBP3 ULBP2 CD276 | cell surface |
  GO:0031343 | 0.000175144520226 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | positive regulation of cell killing |
  GO:0002475 | 0.000189728495656 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation via MHC class Ib |
  GO:0019885 | 0.000243749587868 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation of endogenous peptide antigen via MHC class I |
  GO:0002483 | 0.000385345183326 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation of endogenous peptide antigen |
  KEGG:04650 | 0.000486162823839 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | Natural killer cell mediated cytotoxicity |
  GO:0001910 | 0.000519413573521 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | regulation of leukocyte mediated cytotoxicity |
  GO:0002709 | 0.000519413573521 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | regulation of T cell mediated immunity |
  GO:0002824 | 0.000711556044524 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
  GO:0019883 | 0.000842545270399 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation of endogenous antigen |
  GO:0002708 | 0.00102704336498 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | positive regulation of lymphocyte mediated immunity |
  GO:0031341 | 0.00102704336498 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | regulation of cell killing |
  GO:0002821 | 0.0011017416618 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | positive regulation of adaptive immune response |
  GO:0002449 | 0.00112136422902 | 0.333333333333 | NECTIN2 ULBP1 NCR3LG1 ULBP3 ULBP2 RAET1E | lymphocyte mediated immunity |
  GO:0002460 | 0.00135438492137 | 0.333333333333 | NECTIN2 ULBP1 NCR3LG1 ULBP3 ULBP2 RAET1E | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
  GO:0002474 | 0.00138835627377 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation of peptide antigen via MHC class I |
  GO:0002456 | 0.00164576651215 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | T cell mediated immunity |
  GO:0001909 | 0.00198802728828 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | leukocyte mediated cytotoxicity |
  GO:0002705 | 0.00238461185853 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | positive regulation of leukocyte mediated immunity |
  GO:0005886 | 0.00295464597256 | 0.833333333333 | GABBR2 ULBP3 RYK NECTIN2 PODXL2 NCR3LG1 ULBP1 TNFSF9 ULBP2 ITFG1 CEACAM21 RAET1E SLC2A13 PCDH1 CD276 | plasma membrane |
  GO:0045321 | 0.00520364189867 | 0.444444444444 | CD276 ULBP1 TNFSF9 SLAMF8 CEACAM21 ULBP3 ULBP2 NECTIN2 | leukocyte activation |
  GO:0002443 | 0.00523165676329 | 0.333333333333 | NECTIN2 ULBP1 NCR3LG1 ULBP3 ULBP2 RAET1E | leukocyte mediated immunity |
  GO:0002250 | 0.00538716726242 | 0.333333333333 | NECTIN2 ULBP1 NCR3LG1 ULBP3 ULBP2 RAET1E | adaptive immune response |
  GO:0002252 | 0.00641510854904 | 0.388888888889 | NECTIN2 ULBP1 SLAMF8 RAET1E ULBP3 ULBP2 NCR3LG1 | immune effector process |
  GO:0002697 | 0.00696639876458 | 0.333333333333 | NECTIN2 ULBP1 SLAMF8 RAET1E ULBP3 ULBP2 | regulation of immune effector process |
  GO:0009897 | 0.00736462343048 | 0.333333333333 | CD276 ULBP1 CEACAM21 RAET1E ULBP3 ULBP2 | external side of plasma membrane |
  GO:0002822 | 0.00873360803803 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
  GO:0002706 | 0.00913876265616 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | regulation of lymphocyte mediated immunity |
  GO:0050776 | 0.0106950378132 | 0.444444444444 | CD276 NCR3LG1 ULBP1 SLAMF8 RAET1E ULBP3 ULBP2 NECTIN2 | regulation of immune response |
  GO:0002376 | 0.011134444671 | 0.611111111111 | NECTIN2 PODXL2 NCR3LG1 ULBP1 TNFSF9 SLAMF8 CEACAM21 RAET1E ULBP3 ULBP2 CD276 | immune system process |
  GO:0071944 | 0.0117433502148 | 0.833333333333 | GABBR2 ULBP3 RYK NECTIN2 PODXL2 NCR3LG1 ULBP1 TNFSF9 ULBP2 ITFG1 CEACAM21 RAET1E SLC2A13 PCDH1 CD276 | cell periphery |
  GO:0002819 | 0.0134983448979 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | regulation of adaptive immune response |
  GO:0001906 | 0.016549721368 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | cell killing |
  GO:0001775 | 0.0176340728132 | 0.444444444444 | CD276 ULBP1 TNFSF9 SLAMF8 CEACAM21 ULBP3 ULBP2 NECTIN2 | cell activation |
  GO:0048002 | 0.0194084281835 | 0.222222222222 | ULBP1 ULBP3 RAET1E ULBP2 | antigen processing and presentation of peptide antigen |
  GO:0046649 | 0.0263080148955 | 0.388888888889 | CD276 ULBP1 SLAMF8 CEACAM21 ULBP3 ULBP2 TNFSF9 | lymphocyte activation |
  GO:0002703 | 0.0290961108023 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | regulation of leukocyte mediated immunity |
  GO:0002684 | 0.030797723664 | 0.444444444444 | CD276 NCR3LG1 ULBP1 NECTIN2 RAET1E ULBP3 ULBP2 TNFSF9 | positive regulation of immune system process |
  GO:0002682 | 0.0351212100344 | 0.5 | CD276 NCR3LG1 ULBP1 TNFSF9 SLAMF8 RAET1E ULBP3 ULBP2 NECTIN2 | regulation of immune system process |
  GO:0002699 | 0.0358359127296 | 0.277777777778 | ULBP1 ULBP3 NECTIN2 ULBP2 RAET1E | positive regulation of immune effector process |
  GO:0050778 | 0.0491559551352 | 0.388888888889 | CD276 NCR3LG1 ULBP1 RAET1E ULBP3 ULBP2 NECTIN2 | positive regulation of immune response |
  CORUM:5418 | 0.0496617483143 | 0.0555555555556 | GABBR2 | GABBR2-HTR1A complex |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD |
---|---|---|---|
 CD276 |  RYK | 0.998 |            |
 RYK |  TNFSF9 | 0.997 |            |
 ULBP3 |  ULBP1 | 0.997 |            |
 CEACAM21 |  ULBP1 | 0.996 |            |
 RYK |  NCR3LG1 | 0.994 |            |
 RYK |  PCDH1 | 0.993 |            |
 CEACAM21 |  ITFG1 | 0.992 |            |
 GABBR2 |  CEACAM21 | 0.992 |            |
 ULBP3 |  SLAMF8 | 0.991 |            |
 RYK |  ITFG1 | 0.99 |            |
 CEACAM21 |  TNFSF9 | 0.984 |            |
 ULBP3 |  TNFSF9 | 0.979 | 0.026           |
 CEACAM21 |  RYK | 0.978 |            |
 HBD |  RYK | 0.976 |            |
 ULBP2 |  SLAMF8 | 0.976 |            |
 ULBP2 |  RYK | 0.975 |            |
 PODXL2 |  CEACAM21 | 0.972 |            |
 TNFSF9 |  ITFG1 | 0.968 | 0.098           |
 RAET1E |  TNFSF9 | 0.963 |            |
 ULBP3 |  ITFG1 | 0.959 | 0.088           |
 RAET1E |  PCDH1 | 0.956 |            |
 RAET1E |  RYK | 0.955 |            |
 HBD |  FCRL2 | 0.954 |            |
 HBD |  ULBP3 | 0.952 | 0.116           |
 NECTIN2 |  TNFSF9 | 0.952 | 0.084           |
 HBD |  SLAMF8 | 0.95 |            |
 TNFSF9 |  NCR3LG1 | 0.948 | 0.082           |
 SLC2A13 |  NCR3LG1 | 0.946 |            |
 ULBP2 |  RAET1E | 0.934 |            |
 CEACAM21 |  ULBP3 | 0.934 |            |
 RYK |  ULBP3 | 0.933 |            |
 CEACAM21 |  PCDH1 | 0.925 |            |
 SLAMF8 |  TNFSF9 | 0.917 |            |
 CEACAM21 |  CD276 | 0.913 |            |
 FCRL2 |  TNFSF9 | 0.911 |            |
 HBD |  TNFSF9 | 0.91 |            |
 NECTIN2 |  ITFG1 | 0.908 | 0.078           |
 CD276 |  NECTIN2 | 0.905 | 0.042           |
 RYK |  NECTIN2 | 0.901 |            |
 CEACAM21 |  HBD | 0.889 |            |
 ULBP3 |  NECTIN2 | 0.861 | 0.078           |
 PODXL2 |  ULBP3 | 0.858 | 0.09           |
 SLAMF8 |  ITFG1 | 0.856 |            |
 RYK |  ULBP1 | 0.849 |            |
 CD276 |  TNFSF9 | 0.849 | 0.094           |
 HBD |  CD276 | 0.834 | 0.086           |
 CD276 |  NCR3LG1 | 0.833 | 0.152           |
 PODXL2 |  HBD | 0.828 | 0.076           |
 RAET1E |  ITFG1 | 0.806 |            |
 PODXL2 |  TNFSF9 | 0.803 | 0.088           |
 ULBP3 |  NCR3LG1 | 0.801 | 0.154           |
 HBD |  NCR3LG1 | 0.78 | 0.07           |
 CD276 |  ITFG1 | 0.769 | 0.14           |
 PODXL2 |  RYK | 0.768 |            |
 PODXL2 |  NCR3LG1 | 0.765 | 0.116           |
 PODXL2 |  ITFG1 | 0.762 | 0.074           |
 HBD |  ITFG1 | 0.76 | 0.084           |
 FCRL2 |  ITFG1 | 0.755 |            |
 ULBP1 |  ITFG1 | 0.718 |            |
 ULBP1 |  TNFSF9 | 0.712 |            |
 HBD |  ULBP1 | 0.69 |            |
 RAET1E |  NCR3LG1 | 0.678 |            |
 PODXL2 |  RAET1E | 0.645 |            |
 ULBP2 |  HBD | 0.606 | 0.074           |
 ULBP2 |  ULBP3 | 0.558 | 0.102           |
 HBD |  NECTIN2 | 0.541 | 0.03           |
 ULBP1 |  NECTIN2 | 0.454 |            |
 CEACAM21 |  NECTIN2 | 0.45 |            |
 CD276 |  PCDH1 | 0.449 |            |
 RAET1E |  ULBP3 | 0.436 |            |
 PCDH1 |  NECTIN2 | 0.416 |            |
 PCDH1 |  TNFSF9 | 0.387 |            |
 ULBP2 |  TNFSF9 | 0.338 | 0.088           |
 NCR3LG1 |  ITFG1 | 0.328 | 0.072           |
 ULBP2 |  NCR3LG1 | 0.318 | 0.088           |
 CD276 |  RAET1E | 0.307 |            |
 PODXL2 |  CD276 | 0.303 | 0.068           |
 ULBP3 |  PCDH1 | 0.296 |            |
 ULBP2 |  ITFG1 | 0.287 | 0.066           |
 GABBR2 |  NCR3LG1 | 0.284 |            |
 NECTIN2 |  NCR3LG1 | 0.272 | 0.086           |
 CD276 |  ULBP3 | 0.253 | 0.088           |
 ULBP1 |  PCDH1 | 0.243 |            |
 CEACAM21 |  NCR3LG1 | 0.237 |            |
 PODXL2 |  NECTIN2 | 0.218 | 0.03           |
 GABBR2 |  PODXL2 | 0.213 |            |
 PCDH1 |  ITFG1 | 0.208 |            |
 GABBR2 |  ULBP3 | 0.194 |            |
 PODXL2 |  ULBP1 | 0.188 |            |
 GABBR2 |  CD276 | 0.187 |            |
 ULBP2 |  ULBP1 | 0.183 |            |
 ULBP1 |  NCR3LG1 | 0.181 |            |
 GABBR2 |  NECTIN2 | 0.171 |            |
 RYK |  SLC2A13 | 0.164 |            |
 GABBR2 |  RYK | 0.164 |            |
 GABBR2 |  TNFSF9 | 0.159 |            |
 HBD |  PCDH1 | 0.159 |            |
 CD276 |  ULBP1 | 0.147 |            |
 ULBP2 |  CD276 | 0.144 | 0.06           |
 PODXL2 |  ULBP2 | 0.144 | 0.084           |
 ULBP2 |  PCDH1 | 0.138 |            |
 ULBP2 |  NECTIN2 | 0.133 | 0.112           |
 GABBR2 |  HBD | 0.125 |            |
 GABBR2 |  ITFG1 | 0.113 |            |
 PCDH1 |  NCR3LG1 | 0.11 |            |
 PODXL2 |  PCDH1 | 0.098 |            |
 HBD |  SLC2A13 | 0.082 |            |
 HBD |  RAET1E | 0.07 |            |
 SLC2A13 |  TNFSF9 | 0.058 |            |
 GABBR2 |  PCDH1 | 0.048 |            |
 GABBR2 |  ULBP1 | 0.046 |            |
Related Complexes