hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14144.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | 5 | UniProt NCBI |
| SLC2A7 | Solute carrier family 2, facilitated glucose transporter member 7 (Glucose transporter type 7) (GLUT-7) (hGLUT7) | 5 | UniProt NCBI |
| RNF10 | E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10) | 5 | UniProt NCBI |
| UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1) | 5 | UniProt NCBI |
| URGCP | Up-regulator of cell proliferation (HBV X protein up-regulated gene 4 protein) (HBxAg up-regulated gene 4 protein) | 5 | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING finger protein AO7) | 5 | UniProt NCBI |
| UBE2E3 | Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) | 5 | UniProt NCBI |
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | 5 | UniProt NCBI |
| ADAMTS3 | A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04120 | 4.2792504245e-05 | 0.444444444444 | UBE2D4 UBE2D3 UBE2D1 UBE2E3 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-983168 | 7.2355980473e-05 | 0.555555555556 | UBE2D4 UBE2D3 UBE2E3 UBE2D1 RNF25 | Antigen processing: Ubiquitination & Proteasome degradation |
| GO:0061631 | 9.02134234826e-05 | 0.444444444444 | UBE2D4 UBE2D3 UBE2D1 UBE2E3 | ubiquitin conjugating enzyme activity |
| GO:0061650 | 0.000172125683501 | 0.444444444444 | UBE2D4 UBE2D3 UBE2D1 UBE2E3 | ubiquitin-like protein conjugating enzyme activity |
| REAC:R-HSA-983169 | 0.000199544661983 | 0.555555555556 | UBE2D4 UBE2D3 UBE2E3 UBE2D1 RNF25 | Class I MHC mediated antigen processing & presentation |
| GO:0004842 | 0.000644356146208 | 0.666666666667 | UBE2D4 RNF10 UBE2D1 RNF25 UBE2E3 UBE2D3 | ubiquitin-protein transferase activity |
| KEGG:03083 | 0.000679986209508 | 0.333333333333 | UBE2D4 UBE2D1 UBE2D3 | Polycomb repressive complex |
| GO:0019787 | 0.00102870161776 | 0.666666666667 | UBE2D4 RNF10 UBE2D1 RNF25 UBE2E3 UBE2D3 | ubiquitin-like protein transferase activity |
| GO:0016755 | 0.00126292687721 | 0.666666666667 | UBE2D4 RNF10 UBE2D1 RNF25 UBE2E3 UBE2D3 | aminoacyltransferase activity |
| REAC:R-HSA-8852135 | 0.00242682057997 | 0.333333333333 | UBE2E3 UBE2D1 UBE2D3 | Protein ubiquitination |
| GO:0085020 | 0.00292902387419 | 0.333333333333 | UBE2D4 RNF25 UBE2D3 | protein K6-linked ubiquitination |
| GO:0070936 | 0.00334782846127 | 0.444444444444 | UBE2D4 UBE2D3 UBE2D1 UBE2E3 | protein K48-linked ubiquitination |
| GO:0000209 | 0.00413679472038 | 0.555555555556 | UBE2D4 UBE2D3 UBE2E3 UBE2D1 RNF25 | protein polyubiquitination |
| KEGG:04141 | 0.00483284608142 | 0.333333333333 | UBE2D4 UBE2D1 UBE2D3 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-1280218 | 0.00488874967394 | 0.555555555556 | UBE2D4 UBE2D3 UBE2E3 UBE2D1 RNF25 | Adaptive Immune System |
| GO:0016567 | 0.00730404922177 | 0.666666666667 | UBE2D4 RNF10 UBE2D1 RNF25 UBE2E3 UBE2D3 | protein ubiquitination |
| GO:0016746 | 0.0117309781293 | 0.666666666667 | UBE2D4 RNF10 UBE2D1 RNF25 UBE2E3 UBE2D3 | acyltransferase activity |
| REAC:R-HSA-168927 | 0.0135859457713 | 0.222222222222 | UBE2D1 UBE2D3 | TICAM1, RIP1-mediated IKK complex recruitment |
| KEGG:05131 | 0.0146549467572 | 0.333333333333 | UBE2D4 UBE2D1 UBE2D3 | Shigellosis |
| REAC:R-HSA-937041 | 0.0150906736209 | 0.222222222222 | UBE2D1 UBE2D3 | IKK complex recruitment mediated by RIP1 |
| GO:0032446 | 0.0156608922208 | 0.666666666667 | UBE2D4 RNF10 UBE2D1 RNF25 UBE2E3 UBE2D3 | protein modification by small protein conjugation |
| REAC:R-HSA-9705462 | 0.0200751738188 | 0.222222222222 | UBE2D1 UBE2D3 | Inactivation of CSF3 (G-CSF) signaling |
| REAC:R-HSA-201451 | 0.0237893486791 | 0.222222222222 | UBE2D1 UBE2D3 | Signaling by BMP |
| GO:0070979 | 0.0262477173145 | 0.333333333333 | UBE2D4 UBE2D3 UBE2E3 | protein K11-linked ubiquitination |
| GO:0070647 | 0.0280697756258 | 0.666666666667 | UBE2D4 RNF10 UBE2D1 RNF25 UBE2E3 UBE2D3 | protein modification by small protein conjugation or removal |
| REAC:R-HSA-9674555 | 0.0299458635385 | 0.222222222222 | UBE2D1 UBE2D3 | Signaling by CSF3 (G-CSF) |
| REAC:R-HSA-2173795 | 0.032153801025 | 0.222222222222 | UBE2D1 UBE2D3 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| REAC:R-HSA-8866652 | 0.0344394959621 | 0.222222222222 | UBE2E3 UBE2D1 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| GO:0043687 | 0.0413349003112 | 0.666666666667 | UBE2D4 RNF10 UBE2D1 RNF25 UBE2E3 UBE2D3 | post-translational protein modification |
| REAC:R-HSA-936440 | 0.0417623735111 | 0.222222222222 | UBE2D1 UBE2D3 | Negative regulators of DDX58/IFIH1 signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RNF25 | UBE2E3 | 0.999 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D3 | 0.998 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RNF25 | UBE2D1 | 0.997 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RNF25 | UBE2D4 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RNF10 | UBE2E3 | 0.981 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| UBE2D3 | UBE2D1 | 0.975 | 0.369636363636 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D3 | RNF10 | 0.954 | 0.204 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| UBE2D1 | URGCP | 0.947 | 0.242 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| RNF10 | UBE2D4 | 0.946 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RNF25 | SLC2A7 | 0.912 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2D3 | UBE2D4 | 0.909 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| RNF10 | ADAMTS3 | 0.902 | bioplex3_WMM WMM_only | |
| URGCP | UBE2D4 | 0.883 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UBE2D1 | UBE2E3 | 0.869 | 0.295222222222 | bioplex3_WMM WMM_only |
| RNF10 | UBE2D1 | 0.869 | 0.3551 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UBE2D3 | UBE2E3 | 0.823 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D3 | URGCP | 0.708 | 0.102 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| RNF25 | RNF10 | 0.531 | 0.136 | bioplex_WMM bioplex3_WMM WMM_only |
| UBE2D4 | UBE2E3 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBE2D1 | UBE2D4 | 0.214 | bioplex3_WMM WMM_only | |
| RNF25 | URGCP | 0.079 | 0.16 | bioplex3_WMM WMM_only |
| RNF10 | URGCP | 0.079 | 0.084 | bioplex3_WMM WMM_only |
Related Complexes