hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14151.1
Complex Portal: CPX-15948
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| USP25 | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) | 5 | UniProt NCBI |
| BTBD9 | BTB/POZ domain-containing protein 9 | 5 | UniProt NCBI |
| ADAP2 | Arf-GAP with dual PH domain-containing protein 2 (Centaurin-alpha-2) (Cnt-a2) | 5 | UniProt NCBI |
| MTURN | Maturin (Maturin neural progenitor differentiation regulator protein homolog) (Protein Ells1) | 5 | UniProt NCBI |
| KCTD13 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (TNFAIP1-like protein) | 5 | UniProt NCBI |
| KCTD10 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10) | 5 | UniProt NCBI |
| TNFAIP1 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial) | 5 | UniProt NCBI |
| DCUN1D2 | DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2) | 5 | UniProt NCBI |
| HSPB2 | Heat shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035024 | 0.00450341440411 | 0.333333333333 | KCTD13 KCTD10 TNFAIP1 | negative regulation of Rho protein signal transduction |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TNFAIP1 | KCTD13 | 1.0 |
mutually_exclusive (Q9H3F6)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KCTD10 | KCTD13 | 1.0 |
mutually_exclusive (Q13829)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KCTD10 | TNFAIP1 | 0.999 | 0.148 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KCTD10 | HSPB2 | 0.987 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| HSPB2 | BTBD9 | 0.98 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| BTBD9 | KCTD13 | 0.963 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MTURN | TNFAIP1 | 0.96 | 0.082 |
structurally_consistent (Q9H3F6)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| KCTD10 | BTBD9 | 0.946 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KCTD10 | USP25 | 0.924 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| USP25 | BTBD9 | 0.911 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| USP25 | TNFAIP1 | 0.894 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DCUN1D2 | USP25 | 0.883 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| KCTD10 | ADAP2 | 0.854 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TNFAIP1 | BTBD9 | 0.816 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| MTURN | KCTD13 | 0.759 |
structurally_consistent (Q9H3F6)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MTURN | BTBD9 | 0.632 | 0.084 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KCTD10 | MTURN | 0.581 | 0.136 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| DCUN1D2 | KCTD10 | 0.251 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| USP25 | KCTD13 | 0.25 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes