hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14168.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DPH2 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2) | 5 | UniProt NCBI |
| SERGEF | Secretion-regulating guanine nucleotide exchange factor (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF) (Guanine nucleotide exchange factor-related protein) | 5 | UniProt NCBI |
| DPH3 | Diphthamide biosynthesis protein 3 (CSL-type zinc finger-containing protein 2) (DelGEF-interacting protein 1) (DelGIP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5358493 | 0.000143154936711 | 0.666666666667 | DPH2 DPH3 | Synthesis of diphthamide-EEF2 |
| REAC:R-HSA-163841 | 0.00453384142373 | 0.666666666667 | DPH2 DPH3 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation |
| GO:0017183 | 0.0210651876021 | 0.666666666667 | DPH2 DPH3 | protein histidyl modification to diphthamide |
| GO:0018202 | 0.0294899169624 | 0.666666666667 | DPH2 DPH3 | peptidyl-histidine modification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SERGEF | DPH3 | 0.981 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DPH2 | DPH3 | 0.963 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DPH2 | SERGEF | 0.228 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes