hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14168.1

Complex Portal: CPX-12988

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
DPH2	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)	5	UniProt NCBI
SERGEF	Secretion-regulating guanine nucleotide exchange factor (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF) (Guanine nucleotide exchange factor-related protein)	5	UniProt NCBI
DPH3	Diphthamide biosynthesis protein 3 (CSL-type zinc finger-containing protein 2) (DelGEF-interacting protein 1) (DelGIP1)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5358493	0.000143154936711	0.666666666667	DPH3 DPH2	Synthesis of diphthamide-EEF2
REAC:R-HSA-163841	0.00453384142373	0.666666666667	DPH3 DPH2	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
GO:0017183	0.0210651876021	0.666666666667	DPH3 DPH2	protein histidyl modification to diphthamide
GO:0018202	0.0294899169624	0.666666666667	DPH3 DPH2	peptidyl-histidine modification

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
SERGEF	DPH3	0.981	0.228		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DPH2	DPH3	0.963	0.062		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DPH2	SERGEF	0.228	0.05		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
DPH2	huMAP3_00369.1 huMAP3_05866.1 huMAP3_07390.1 huMAP3_09661.1 huMAP3_10066.1 huMAP3_10779.1 huMAP3_13227.1 huMAP3_14168.1 huMAP3_14723.1
SERGEF	huMAP3_02967.1 huMAP3_11442.1 huMAP3_12122.1 huMAP3_14168.1 huMAP3_14860.1
DPH3	huMAP3_02967.1 huMAP3_04450.1 huMAP3_06612.1 huMAP3_14168.1