hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14174.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NEIL1 | Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) | 5 | UniProt NCBI |
| VASH2 | Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein) | 5 | UniProt NCBI |
| WRN | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9675135 | 0.00800131218049 | 0.666666666667 | NEIL1 WRN | Diseases of DNA repair |
| CORUM:4082 | 0.0249718442456 | 0.333333333333 | WRN | XRCC6-XRCC5-WRN complex |
| REAC:R-HSA-9616334 | 0.0498224659464 | 0.333333333333 | NEIL1 | Defective Base Excision Repair Associated with NEIL1 |
| CORUM:1217 | 0.0499402709677 | 0.333333333333 | WRN | WRN-TRF2 complex |
| CORUM:5235 | 0.0499402709677 | 0.333333333333 | WRN | WRN-Ku70-Ku80-PARP1 complex |
| CORUM:7282 | 0.0499402709677 | 0.333333333333 | WRN | FEN1-WRN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NEIL1 | WRN | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NEIL1 | VASH2 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| WRN | VASH2 | 0.078 | bioplex3_WMM WMM_only |
Related Complexes