hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14175.1
Complex Portal: CPX-22424
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| REEP3 | Receptor expression-enhancing protein 3 | 4 | UniProt NCBI |
| SARM1 | NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR) | 5 | UniProt NCBI |
| CAV3 | Caveolin-3 (M-caveolin) | 5 | UniProt NCBI |
| REEP1 | Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein) | 5 | UniProt NCBI |
| REEP2 | Receptor expression-enhancing protein 2 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0071786 | 0.00109385703544 | 0.6 | REEP1 REEP3 REEP2 | endoplasmic reticulum tubular network organization |
| GO:0071782 | 0.00350285844735 | 0.6 | REEP1 REEP3 REEP2 | endoplasmic reticulum tubular network |
| GO:0099512 | 0.00395121770293 | 1.0 | REEP1 REEP2 CAV3 REEP3 SARM1 | supramolecular fiber |
| GO:0099081 | 0.00420676058059 | 1.0 | REEP1 REEP2 CAV3 REEP3 SARM1 | supramolecular polymer |
| GO:0005874 | 0.0289172689799 | 0.8 | REEP1 REEP2 REEP3 SARM1 | microtubule |
| HP:0001761 | 0.03503731332 | 0.6 | REEP1 CAV3 REEP2 | Pes cavus |
| GO:0099080 | 0.0373995595185 | 1.0 | REEP1 REEP2 CAV3 REEP3 SARM1 | supramolecular complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| REEP3 | REEP1 | 0.998 | 0.114 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CAV3 | REEP2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| REEP1 | CAV3 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| REEP1 | REEP2 | 0.984 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SARM1 | CAV3 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| REEP3 | REEP2 | 0.899 | 0.08 |
mutually_exclusive (Q9H902)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| SARM1 | REEP2 | 0.187 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| SARM1 | REEP1 | 0.165 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes