hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14210.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GABRB2 | Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2) | 5 | UniProt NCBI |
| GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) | 5 | UniProt NCBI |
| GLRA3 | Glycine receptor subunit alpha-3 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0099095 | 2.11464090368e-05 | 1.0 | GABRB3 GABRB2 GLRA3 | ligand-gated monoatomic anion channel activity |
| KEGG:04080 | 5.60236181806e-05 | 1.0 | GABRB3 GABRB2 GLRA3 | Neuroactive ligand-receptor interaction |
| KEGG:05033 | 0.000210478859947 | 0.666666666667 | GABRB3 GABRB2 | Nicotine addiction |
| REAC:R-HSA-112314 | 0.000300937850546 | 1.0 | GABRB3 GABRB2 GLRA3 | Neurotransmitter receptors and postsynaptic signal transmission |
| WP:WP4159 | 0.000312323469599 | 0.666666666667 | GABRB3 GABRB2 | GABA receptor signaling |
| WP:WP4829 | 0.000459327445001 | 0.666666666667 | GABRB3 GABRB2 | mBDNF and proBDNF regulation of GABA neurotransmission |
| GO:1902476 | 0.000629105668845 | 1.0 | GABRB3 GABRB2 GLRA3 | chloride transmembrane transport |
| REAC:R-HSA-112315 | 0.000640971827897 | 1.0 | GABRB3 GABRB2 GLRA3 | Transmission across Chemical Synapses |
| GO:0022824 | 0.000949666005835 | 1.0 | GABRB3 GABRB2 GLRA3 | transmitter-gated monoatomic ion channel activity |
| GO:0022835 | 0.000949666005835 | 1.0 | GABRB3 GABRB2 GLRA3 | transmitter-gated channel activity |
| GO:0005230 | 0.00136394338287 | 1.0 | GABRB3 GABRB2 GLRA3 | extracellular ligand-gated monoatomic ion channel activity |
| GO:0098656 | 0.00136394338287 | 1.0 | GABRB3 GABRB2 GLRA3 | monoatomic anion transmembrane transport |
| GO:0005254 | 0.00136394338287 | 1.0 | GABRB3 GABRB2 GLRA3 | chloride channel activity |
| GO:0098661 | 0.00145910222354 | 1.0 | GABRB3 GABRB2 GLRA3 | inorganic anion transmembrane transport |
| KEGG:04727 | 0.00168280767129 | 0.666666666667 | GABRB3 GABRB2 | GABAergic synapse |
| KEGG:05032 | 0.00173372250929 | 0.666666666667 | GABRB3 GABRB2 | Morphine addiction |
| GO:0030594 | 0.00200169985542 | 1.0 | GABRB3 GABRB2 GLRA3 | neurotransmitter receptor activity |
| REAC:R-HSA-112316 | 0.00203732306248 | 1.0 | GABRB3 GABRB2 GLRA3 | Neuronal System |
| GO:0006821 | 0.00238416149886 | 1.0 | GABRB3 GABRB2 GLRA3 | chloride transport |
| KEGG:04726 | 0.00265115528622 | 0.666666666667 | GABRB3 GABRB2 | Serotonergic synapse |
| GO:0005253 | 0.00266444753864 | 1.0 | GABRB3 GABRB2 GLRA3 | monoatomic anion channel activity |
| GO:0015108 | 0.00439845307966 | 1.0 | GABRB3 GABRB2 GLRA3 | chloride transmembrane transporter activity |
| KEGG:04723 | 0.00533101781525 | 0.666666666667 | GABRB3 GABRB2 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-977443 | 0.005581186855 | 0.666666666667 | GABRB3 GABRB2 | GABA receptor activation |
| REAC:R-HSA-1236394 | 0.00614555007695 | 0.666666666667 | GABRB3 GABRB2 | Signaling by ERBB4 |
| GO:0006820 | 0.00623088554274 | 1.0 | GABRB3 GABRB2 GLRA3 | monoatomic anion transport |
| GO:0015698 | 0.00649050577369 | 1.0 | GABRB3 GABRB2 GLRA3 | inorganic anion transport |
| GO:0008509 | 0.00820096190464 | 1.0 | GABRB3 GABRB2 GLRA3 | monoatomic anion transmembrane transporter activity |
| GO:0015103 | 0.00949377645712 | 1.0 | GABRB3 GABRB2 GLRA3 | inorganic anion transmembrane transporter activity |
| GO:0071420 | 0.0140440992017 | 0.666666666667 | GABRB3 GABRB2 | cellular response to histamine |
| GO:0022834 | 0.0180186629002 | 1.0 | GABRB3 GABRB2 GLRA3 | ligand-gated channel activity |
| GO:0015276 | 0.0180186629002 | 1.0 | GABRB3 GABRB2 GLRA3 | ligand-gated monoatomic ion channel activity |
| GO:0034776 | 0.0294899169624 | 0.666666666667 | GABRB3 GABRB2 | response to histamine |
| WP:WP5420 | 0.0379798583444 | 0.666666666667 | GABRB3 GABRB2 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0022851 | 0.0393180950424 | 0.666666666667 | GABRB3 GABRB2 | GABA-gated chloride ion channel activity |
| CORUM:7462 | 0.0499402709677 | 0.333333333333 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRD) |
| CORUM:5809 | 0.0499402709677 | 0.333333333333 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRG2) |
| CORUM:7461 | 0.0499402709677 | 0.333333333333 | GABRB2 | GABA-A receptor (GABRA1, GABRB2, GABRG2) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GABRB2 | GABRB3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GLRA3 | GABRB3 | 0.938 | bioplex3_HEK293 bioplex3_WMM WMM_only |
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