hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14233.1

Complex Portal: CPX-19551

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
MAN2B1	Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide]	5	UniProt NCBI
LAMC3	Laminin subunit gamma-3 (Laminin-12 subunit gamma) (Laminin-14 subunit gamma) (Laminin-15 subunit gamma)	5	UniProt NCBI
LAMA4	Laminin subunit alpha-4 (Laminin-14 subunit alpha) (Laminin-8 subunit alpha) (Laminin-9 subunit alpha)	5	UniProt NCBI
LAMB1	Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta)	5	UniProt NCBI
LAMA1	Laminin subunit alpha-1 (Laminin A chain) (Laminin-1 subunit alpha) (Laminin-3 subunit alpha) (S-laminin subunit alpha) (S-LAM alpha)	5	UniProt NCBI
BTD	Biotinidase (Biotinase) (EC 3.5.1.12)	5	UniProt NCBI
SPINK4	Serine protease inhibitor Kazal-type 4 (Peptide PEC-60 homolog)	2	UniProt NCBI
IGSF3	Immunoglobulin superfamily member 3 (IgSF3) (Glu-Trp-Ile EWI motif-containing protein 3) (EWI-3)	5	UniProt NCBI
LAMC1	Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)	5	UniProt NCBI
NID1	Nidogen-1 (NID-1) (Entactin)	5	UniProt NCBI
LAMA3	Laminin subunit alpha-3 (Epiligrin 170 kDa subunit) (E170) (Epiligrin subunit alpha) (Kalinin subunit alpha) (Laminin-5 subunit alpha) (Laminin-6 subunit alpha) (Laminin-7 subunit alpha) (Nicein subunit alpha)	5	UniProt NCBI
PPT2	Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) (S-thioesterase G14)	5	UniProt NCBI
NID2	Nidogen-2 (NID-2) (Osteonidogen)	5	UniProt NCBI
IDO1	Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-3000157	8.79412801487e-10	0.5	LAMC3 NID2 LAMA4 LAMA3 LAMB1	Laminin interactions
REAC:R-HSA-8874081	2.8179151173e-07	0.4	LAMC3 LAMA4 LAMA3 LAMB1	MET activates PTK2 signaling
REAC:R-HSA-8875878	1.22580923685e-06	0.4	LAMC3 LAMA4 LAMA3 LAMB1	MET promotes cell motility
KEGG:04512	4.17766011535e-06	0.4	LAMC3 LAMA4 LAMA3 LAMB1	ECM-receptor interaction
REAC:R-HSA-3000171	5.11949202063e-06	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Non-integrin membrane-ECM interactions
KEGG:05222	1.15020714318e-05	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Small cell lung cancer
KEGG:05146	1.15020714318e-05	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Amoebiasis
KEGG:05145	1.44524606261e-05	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Toxoplasmosis
REAC:R-HSA-6806834	2.25886615223e-05	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Signaling by MET
WP:WP4658	2.5825431588e-05	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Small cell lung cancer
REAC:R-HSA-1474244	5.05152990437e-05	0.5	LAMC3 NID2 LAMA4 LAMA3 LAMB1	Extracellular matrix organization
KEGG:04510	0.000189687515923	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Focal adhesion
WP:WP306	0.000370786817543	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Focal adhesion
GO:0005604	0.000499046750281	0.4	LAMA3 NID2 LAMA4 LAMB1	basement membrane
KEGG:04151	0.00138373215648	0.4	LAMC3 LAMA4 LAMA3 LAMB1	PI3K-Akt signaling pathway
KEGG:05165	0.00154195382833	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Human papillomavirus infection
WP:WP3932	0.00154367635208	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Focal adhesion PI3K Akt mTOR signaling pathway
REAC:R-HSA-3000178	0.00168567421844	0.3	LAMA3 LAMA4 LAMB1	ECM proteoglycans
WP:WP4172	0.00218880993694	0.4	LAMC3 LAMA4 LAMA3 LAMB1	PI3K Akt signaling pathway
WP:WP5087	0.0075599887011	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Pleural mesothelioma
KEGG:05200	0.00781674670163	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Pathways in cancer
WP:WP244	0.0203472698002	0.2	LAMA3 LAMB1	Alpha 6 beta 4 signaling pathway
REAC:R-HSA-9006934	0.0331471231971	0.4	LAMC3 LAMA4 LAMA3 LAMB1	Signaling by Receptor Tyrosine Kinases
GO:0005201	0.035560081123	0.4	LAMA3 NID2 LAMA4 LAMB1	extracellular matrix structural constituent

Edges

Protein 1	Protein 2	Score	ProteomeHD
LAMC1	NID2	0.997	0.53
LAMB1	NID2	0.997	0.372
LAMA4	NID2	0.988	0.264
MAN2B1	IDO1	0.972
SPINK4	LAMA3	0.966
LAMB1	LAMC1	0.964	0.562
MAN2B1	PPT2	0.96	0.114
LAMB1	LAMC3	0.951	0.172
LAMA3	MAN2B1	0.95	0.05
NID1	NID2	0.942	0.388
LAMA1	LAMB1	0.93	0.328
MAN2B1	NID2	0.929	0.058
LAMC1	MAN2B1	0.903	0.11
LAMB1	LAMA4	0.901	0.444
LAMA1	NID2	0.899	0.084
LAMC1	LAMC3	0.898	0.16
IGSF3	MAN2B1	0.893	0.048
LAMB1	MAN2B1	0.891	0.11
NID1	LAMC3	0.89	0.194
LAMB1	IGSF3	0.883	0.106
LAMB1	LAMA3	0.862	0.306
LAMB1	PPT2	0.854	0.074
LAMC1	IGSF3	0.849	0.064
LAMA1	LAMC1	0.841	0.318
MAN2B1	BTD	0.834	0.058
NID1	LAMA3	0.826	0.262
LAMA3	BTD	0.815	0.066
LAMC1	PPT2	0.812	0.078
LAMC1	LAMA3	0.811	0.42
LAMA3	PPT2	0.808	0.03
IGSF3	PPT2	0.772	0.046
LAMA1	LAMA4	0.712	0.196
IGSF3	LAMA3	0.698	0.022
LAMC1	LAMA4	0.654	0.408
LAMA1	MAN2B1	0.645	0.098
NID1	MAN2B1	0.636	0.122
NID1	PPT2	0.628	0.068
LAMA3	NID2	0.622	0.226
LAMA4	MAN2B1	0.62	0.118
IGSF3	LAMA4	0.597	0.062
PPT2	LAMC3	0.587	0.068
LAMB1	BTD	0.49	0.0520512820513
NID2	BTD	0.453	0.06
MAN2B1	LAMC3	0.435	0.024
NID1	LAMC1	0.426	0.442
LAMA3	LAMC3	0.423	0.138
NID1	LAMB1	0.412	0.46
NID1	BTD	0.412	0.042
NID1	LAMA4	0.319	0.448
IGSF3	NID2	0.314	0.062
LAMA1	IGSF3	0.3	0.058
NID1	LAMA1	0.261	0.252
LAMA1	LAMA3	0.246	0.16
SPINK4	BTD	0.168
IGSF3	LAMC3	0.16	0.064
LAMA1	BTD	0.132	0.152
PPT2	BTD	0.116	0.072
NID1	IGSF3	0.097	0.072
LAMA4	PPT2	0.082	0.056
LAMA3	LAMA4	0.073	0.206
LAMA4	BTD	0.064	0.138
LAMC1	BTD	0.063	0.128
IGSF3	BTD	0.056	0.082
LAMA1	PPT2	0.056	0.06
LAMC1	SPINK4	0.052	0.108
NID2	PPT2	0.049	0.022
LAMA1	LAMC3	0.041	0.266
LAMA4	LAMC3	0.041	0.202
NID2	LAMC3	0.038	0.102
LAMC3	BTD	0.015	0.1

Related Complexes

Genename	Complexes
MAN2B1	huMAP3_03828.1 huMAP3_05774.1 huMAP3_14233.1
LAMC3	huMAP3_10335.1 huMAP3_14233.1 huMAP3_15307.1
LAMA4	huMAP3_03825.1 huMAP3_04483.1 huMAP3_07123.1 huMAP3_09054.1 huMAP3_09771.1 huMAP3_10056.1 huMAP3_10163.1 huMAP3_10902.1 huMAP3_11510.1 huMAP3_12563.1 huMAP3_14233.1
LAMB1	huMAP3_01175.1 huMAP3_08112.1 huMAP3_14233.1
LAMA1	huMAP3_00885.1 huMAP3_01090.1 huMAP3_03051.1 huMAP3_11101.1 huMAP3_14233.1
BTD	huMAP3_12928.1 huMAP3_14233.1
SPINK4	huMAP3_03076.1 huMAP3_12308.1 huMAP3_12499.1 huMAP3_12928.1 huMAP3_14233.1
IGSF3	huMAP3_01194.1 huMAP3_04036.1 huMAP3_10916.1 huMAP3_11022.1 huMAP3_11349.1 huMAP3_14233.1
LAMC1	huMAP3_01175.1 huMAP3_08112.1 huMAP3_14233.1
NID1	huMAP3_00303.1 huMAP3_05913.1 huMAP3_12928.1 huMAP3_14233.1
LAMA3	huMAP3_03076.1 huMAP3_07180.1 huMAP3_07711.1 huMAP3_09215.1 huMAP3_12928.1 huMAP3_14233.1
PPT2	huMAP3_05774.1 huMAP3_06418.1 huMAP3_07947.1 huMAP3_09215.1 huMAP3_09297.1 huMAP3_11275.1 huMAP3_13392.1 huMAP3_14233.1
NID2	huMAP3_04017.1 huMAP3_04471.1 huMAP3_04483.1 huMAP3_04766.1 huMAP3_07123.1 huMAP3_09054.1 huMAP3_09771.1 huMAP3_10056.1 huMAP3_10902.1 huMAP3_11510.1 huMAP3_14233.1
IDO1	huMAP3_03828.1 huMAP3_12408.1 huMAP3_13807.1 huMAP3_14233.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14233.1

Complex Portal: CPX-19551