hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14235.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HEXB | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | 5 | UniProt NCBI |
| GAL3ST1 | Galactosylceramide sulfotransferase (GalCer sulfotransferase) (EC 2.8.2.11) (3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase) (3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase) (Cerebroside sulfotransferase) | 5 | UniProt NCBI |
| GLA | Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Galactosylgalactosylglucosylceramidase GLA) (Melibiase) (Agalsidase) | 5 | UniProt NCBI |
| PLA2G15 | Phospholipase A2 group XV (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A and acyltransferase) (EC 2.3.1.-, EC 3.1.1.32, EC 3.1.1.4) (Lysosomal phospholipase A2) (LPLA2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00600 | 5.55380902404e-06 | 0.75 | GLA HEXB GAL3ST1 | Sphingolipid metabolism |
| GO:0006672 | 4.37773767152e-05 | 1.0 | GLA HEXB PLA2G15 GAL3ST1 | ceramide metabolic process |
| KEGG:04142 | 0.00010324564632 | 0.75 | PLA2G15 HEXB GLA | Lysosome |
| KEGG:00603 | 0.000195444706059 | 0.5 | HEXB GLA | Glycosphingolipid biosynthesis - globo and isoglobo series |
| GO:0006665 | 0.000216146949309 | 1.0 | GLA HEXB PLA2G15 GAL3ST1 | sphingolipid metabolic process |
| WP:WP4153 | 0.000346844620397 | 0.5 | HEXB GLA | Degradation pathway of sphingolipids including diseases |
| WP:WP5292 | 0.000484429625977 | 0.5 | GAL3ST1 GLA | Glycosphingolipid metabolism |
| GO:0006643 | 0.000592905829921 | 1.0 | GLA HEXB PLA2G15 GAL3ST1 | membrane lipid metabolic process |
| HP:0004343 | 0.000701980712879 | 0.5 | HEXB GLA | Abnormal glycosphingolipid metabolism |
| HP:0031006 | 0.000701980712879 | 0.5 | HEXB GLA | Acroparesthesia |
| HP:0010969 | 0.00220521848756 | 0.5 | HEXB GLA | Abnormality of glycolipid metabolism |
| REAC:R-HSA-1660662 | 0.007571530532 | 0.5 | HEXB GLA | Glycosphingolipid metabolism |
| GO:0006687 | 0.0079870728422 | 0.75 | GLA HEXB GAL3ST1 | glycosphingolipid metabolic process |
| CORUM:6275 | 0.0249718442456 | 0.25 | HEXB | HEXB homodimer complex |
| REAC:R-HSA-428157 | 0.0267695204965 | 0.5 | HEXB GLA | Sphingolipid metabolism |
| GO:0006664 | 0.0351813641256 | 0.75 | GLA HEXB GAL3ST1 | glycolipid metabolic process |
| GO:1903509 | 0.0351813641256 | 0.75 | GLA HEXB GAL3ST1 | liposaccharide metabolic process |
| CORUM:6274 | 0.049938562206 | 0.25 | HEXB | HEXA-HEXB complex |
| REAC:R-HSA-3656248 | 0.0499436884912 | 0.25 | HEXB | Defective HEXB causes GM2G2 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GAL3ST1 | GLA | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PLA2G15 | GLA | 0.948 | 0.064 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PLA2G15 | HEXB | 0.854 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
| HEXB | GLA | 0.008 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes