hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14247.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SHANK2 | SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1) | 5 | UniProt NCBI |
| FAM222A | Protein FAM222A | 2 | UniProt NCBI |
| MYLK3 | Myosin light chain kinase 3 (EC 2.7.11.18) (Cardiac-MyBP-C-associated Ca/CaM kinase) (Cardiac-MLCK) | 5 | UniProt NCBI |
| MAPK12 | Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3) | 5 | UniProt NCBI |
| NLK | Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) | 5 | UniProt NCBI |
| FAM222B | Protein FAM222B | 5 | UniProt NCBI |
| MAPK13 | Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04611 | 0.00052377688541 | 0.428571428571 | MYLK3 MAPK12 MAPK13 | Platelet activation |
| KEGG:04068 | 0.000803810173213 | 0.428571428571 | NLK MAPK12 MAPK13 | FoxO signaling pathway |
| REAC:R-HSA-376172 | 0.00106560242715 | 0.285714285714 | MAPK13 MAPK12 | DSCAM interactions |
| GO:0004707 | 0.00152694380207 | 0.428571428571 | NLK MAPK12 MAPK13 | MAP kinase activity |
| REAC:R-HSA-171007 | 0.00171179400053 | 0.285714285714 | MAPK13 MAPK12 | p38MAPK events |
| WP:WP4767 | 0.00303405736115 | 0.285714285714 | MAPK13 MAPK12 | FGFR3 signaling in chondrocyte proliferation and terminal differentiation |
| WP:WP5272 | 0.00303405736115 | 0.285714285714 | MAPK13 MAPK12 | LDL influence on CD14 and TLR4 |
| WP:WP4864 | 0.00337040555802 | 0.285714285714 | MAPK13 MAPK12 | Host pathogen interaction of human coronaviruses apoptosis |
| REAC:R-HSA-167044 | 0.00345846977329 | 0.285714285714 | MAPK13 MAPK12 | Signalling to RAS |
| WP:WP3612 | 0.00409583359214 | 0.285714285714 | MAPK13 MAPK12 | Photodynamic therapy induced NFE2L2 NRF2 survival signaling |
| WP:WP3869 | 0.00531562340489 | 0.285714285714 | MAPK13 MAPK12 | Cannabinoid receptor signaling |
| WP:WP2643 | 0.00621644086214 | 0.285714285714 | MAPK13 MAPK12 | Nanoparticle mediated activation of receptor signaling |
| WP:WP4877 | 0.00769886208303 | 0.285714285714 | MAPK13 MAPK12 | Host pathogen interaction of human coronaviruses MAPK signaling |
| WP:WP382 | 0.00780086249264 | 0.428571428571 | NLK MAPK12 MAPK13 | MAPK signaling pathway |
| KEGG:04010 | 0.00789399135774 | 0.428571428571 | NLK MAPK12 MAPK13 | MAPK signaling pathway |
| WP:WP2371 | 0.00991981492579 | 0.285714285714 | MAPK13 MAPK12 | Parkinson 39 s disease pathway |
| REAC:R-HSA-187687 | 0.0123178965954 | 0.285714285714 | MAPK13 MAPK12 | Signalling to ERKs |
| KEGG:04370 | 0.0129401293802 | 0.285714285714 | MAPK13 MAPK12 | VEGF signaling pathway |
| KEGG:04664 | 0.0139791020136 | 0.285714285714 | MAPK13 MAPK12 | Fc epsilon RI signaling pathway |
| WP:WP3611 | 0.0159344117177 | 0.285714285714 | MAPK13 MAPK12 | Photodynamic therapy induced AP 1 survival signaling |
| KEGG:05133 | 0.0173334447573 | 0.285714285714 | MAPK13 MAPK12 | Pertussis |
| REAC:R-HSA-168638 | 0.0187732752758 | 0.285714285714 | MAPK13 MAPK12 | NOD1/2 Signaling Pathway |
| KEGG:04917 | 0.0191438277044 | 0.285714285714 | MAPK13 MAPK12 | Prolactin signaling pathway |
| KEGG:05140 | 0.0191438277044 | 0.285714285714 | MAPK13 MAPK12 | Leishmaniasis |
| KEGG:05120 | 0.0197669780141 | 0.285714285714 | MAPK13 MAPK12 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04622 | 0.0210427715268 | 0.285714285714 | MAPK13 MAPK12 | RIG-I-like receptor signaling pathway |
| KEGG:04912 | 0.0230300913808 | 0.285714285714 | MAPK13 MAPK12 | GnRH signaling pathway |
| KEGG:04750 | 0.0237121385349 | 0.285714285714 | MAPK13 MAPK12 | Inflammatory mediator regulation of TRP channels |
| REAC:R-HSA-373752 | 0.0251789059 | 0.285714285714 | MAPK13 MAPK12 | Netrin-1 signaling |
| WP:WP3865 | 0.0251881882105 | 0.285714285714 | MAPK13 MAPK12 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04658 | 0.0272691209555 | 0.285714285714 | MAPK13 MAPK12 | Th1 and Th2 cell differentiation |
| KEGG:04657 | 0.0295204621358 | 0.285714285714 | MAPK13 MAPK12 | IL-17 signaling pathway |
| WP:WP4538 | 0.0311125325099 | 0.285714285714 | MAPK13 MAPK12 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:05235 | 0.0318594422662 | 0.285714285714 | MAPK13 MAPK12 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:01522 | 0.0334673599343 | 0.285714285714 | MAPK13 MAPK12 | Endocrine resistance |
| KEGG:04914 | 0.0334673599343 | 0.285714285714 | MAPK13 MAPK12 | Progesterone-mediated oocyte maturation |
| WP:WP4341 | 0.0343057335824 | 0.285714285714 | MAPK13 MAPK12 | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| WP:WP3303 | 0.0343057335824 | 0.285714285714 | MAPK13 MAPK12 | RAC1 PAK1 p38 MMP2 pathway |
| KEGG:04625 | 0.0359519968772 | 0.285714285714 | MAPK13 MAPK12 | C-type lectin receptor signaling pathway |
| KEGG:04670 | 0.0367995848147 | 0.285714285714 | MAPK13 MAPK12 | Leukocyte transendothelial migration |
| KEGG:04933 | 0.0376568492551 | 0.285714285714 | MAPK13 MAPK12 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04620 | 0.0376568492551 | 0.285714285714 | MAPK13 MAPK12 | Toll-like receptor signaling pathway |
| KEGG:05142 | 0.0385237834173 | 0.285714285714 | MAPK13 MAPK12 | Chagas disease |
| REAC:R-HSA-168643 | 0.0390490515953 | 0.285714285714 | MAPK13 MAPK12 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| KEGG:04659 | 0.040286633797 | 0.285714285714 | MAPK13 MAPK12 | Th17 cell differentiation |
| KEGG:05145 | 0.0411825364664 | 0.285714285714 | MAPK13 MAPK12 | Toxoplasmosis |
| KEGG:04668 | 0.0448625057456 | 0.285714285714 | MAPK13 MAPK12 | TNF signaling pathway |
| KEGG:04722 | 0.0496787672026 | 0.285714285714 | MAPK13 MAPK12 | Neurotrophin signaling pathway |
| KEGG:04935 | 0.0496787672026 | 0.285714285714 | MAPK13 MAPK12 | Growth hormone synthesis, secretion and action |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPK13 | MAPK12 | 0.999 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FAM222A | NLK | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MYLK3 | MAPK12 | 0.996 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NLK | MAPK12 | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FAM222B | NLK | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NLK | SHANK2 | 0.971 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MAPK13 | MYLK3 | 0.956 | 0.058 | bioplex_WMM bioplex3_WMM WMM_only |
| NLK | MYLK3 | 0.904 | bioplex3_WMM WMM_only | |
| NLK | MAPK13 | 0.869 | bioplex3_WMM WMM_only | |
| FAM222B | SHANK2 | 0.415 | 0.048 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| SHANK2 | huMAP3_02220.1 huMAP3_12156.1 huMAP3_14247.1 |
| FAM222A | huMAP3_00965.1 huMAP3_08791.1 huMAP3_10672.1 huMAP3_11161.1 huMAP3_14247.1 |
| MYLK3 | huMAP3_04021.1 huMAP3_08423.1 huMAP3_12156.1 huMAP3_14247.1 |
| MAPK12 | huMAP3_04021.1 huMAP3_12156.1 huMAP3_14247.1 |
| NLK | huMAP3_02220.1 huMAP3_12156.1 huMAP3_14247.1 |
| FAM222B | huMAP3_02220.1 huMAP3_12156.1 huMAP3_14247.1 |
| MAPK13 | huMAP3_04021.1 huMAP3_08423.1 huMAP3_12156.1 huMAP3_14247.1 |