hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14269.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PCDHB13 | Protocadherin beta-13 (PCDH-beta-13) | 4 | UniProt NCBI |
| SECTM1 | Secreted and transmembrane protein 1 (Protein K-12) | 5 | UniProt NCBI |
| ROBO1 | Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) | 5 | UniProt NCBI |
| ZSWIM2 | E3 ubiquitin-protein ligase ZSWIM2 (EC 2.3.2.27) (MEKK1-related protein X) (MEX) (RING-type E3 ubiquitin transferase ZSWIM2) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2) | 4 | UniProt NCBI |
| JAM3 | Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] | 5 | UniProt NCBI |
| IGDCC3 | Immunoglobulin superfamily DCC subclass member 3 (Putative neuronal cell adhesion molecule) | 3 | UniProt NCBI |
| ADGRA2 | Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5) | 5 | UniProt NCBI |
| CLEC4A | C-type lectin domain family 4 member A (C-type lectin DDB27) (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) (Lectin-like immunoreceptor) (CD antigen CD367) | 5 | UniProt NCBI |
| SH2D1B | SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2) | 5 | UniProt NCBI |
| BCAM | Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239) | 5 | UniProt NCBI |
| ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) | 5 | UniProt NCBI |
| SEMA7A | Semaphorin-7A (CDw108) (JMH blood group antigen) (John-Milton-Hargen human blood group Ag) (Semaphorin-K1) (Sema K1) (Semaphorin-L) (Sema L) (CD antigen CD108) | 5 | UniProt NCBI |
| SIRPA | Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a) | 5 | UniProt NCBI |
| MT-ND6 | NADH-ubiquinone oxidoreductase chain 6 (EC 7.1.1.2) (NADH dehydrogenase subunit 6) | 5 | UniProt NCBI |
| SIRPB1 | Signal-regulatory protein beta-1 isoform 3 (SIRP-beta-1 isoform 3) | 4 | UniProt NCBI |
| SIRPG | Signal-regulatory protein gamma (SIRP-gamma) (CD172 antigen-like family member B) (Signal-regulatory protein beta-2) (SIRP-b2) (SIRP-beta-2) (CD antigen CD172g) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-391160 | 5.16619332528e-05 | 0.1875 | SIRPG SIRPA SIRPB1 | Signal regulatory protein family interactions |
| GO:0007155 | 0.00555596222436 | 0.5625 | CLEC4A SIRPB1 PCDHB13 IGDCC3 SIRPA JAM3 ROBO1 BCAM SIRPG | cell adhesion |
| KEGG:04380 | 0.0146291699276 | 0.1875 | SIRPG SIRPA SIRPB1 | Osteoclast differentiation |
| KEGG:04148 | 0.0182647337957 | 0.1875 | SIRPG SIRPA SIRPB1 | Efferocytosis |
| GO:0098609 | 0.045418693831 | 0.4375 | ROBO1 SIRPB1 PCDHB13 IGDCC3 SIRPA JAM3 SIRPG | cell-cell adhesion |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| CLEC4A | ROR1 | 1.0 | |
| CLEC4A | PCDHB13 | 0.998 | |
| CLEC4A | BCAM | 0.997 | |
| CLEC4A | SIRPA | 0.997 | |
| SECTM1 | CLEC4A | 0.997 | |
| CLEC4A | SEMA7A | 0.994 | |
| SIRPG | SIRPA | 0.991 | 0.166 |
| SIRPA | SIRPB1 | 0.99 | 0.382 |
| JAM3 | CLEC4A | 0.987 | |
| CLEC4A | MT-ND6 | 0.981 | |
| SIRPA | SH2D1B | 0.981 | |
| IGDCC3 | CLEC4A | 0.97 | |
| CLEC4A | ROBO1 | 0.943 | |
| BCAM | ZSWIM2 | 0.931 | |
| ROR1 | SIRPA | 0.905 | 0.096 |
| PCDHB13 | SIRPA | 0.904 | |
| ROR1 | PCDHB13 | 0.904 | |
| SECTM1 | ADGRA2 | 0.902 | |
| PCDHB13 | SEMA7A | 0.883 | |
| SEMA7A | SIRPA | 0.881 | 0.054 |
| ROR1 | SEMA7A | 0.881 | 0.054 |
| SECTM1 | SIRPA | 0.869 | |
| ROBO1 | SH2D1B | 0.844 | |
| ROR1 | BCAM | 0.82 | 0.046 |
| SECTM1 | PCDHB13 | 0.722 | |
| BCAM | SIRPA | 0.72 | 0.066 |
| SECTM1 | ROR1 | 0.656 | |
| SECTM1 | SEMA7A | 0.626 | |
| ROR1 | ADGRA2 | 0.415 | |
| MT-ND6 | SIRPA | 0.415 | 0.088 |
| JAM3 | IGDCC3 | 0.415 | |
| IGDCC3 | SIRPA | 0.415 | |
| JAM3 | MT-ND6 | 0.415 | 0.128 |
| ROR1 | MT-ND6 | 0.415 | 0.102 |
| IGDCC3 | MT-ND6 | 0.415 | |
| IGDCC3 | ROR1 | 0.415 | |
| MT-ND6 | SEMA7A | 0.364 | 0.036 |
| IGDCC3 | SEMA7A | 0.364 | |
| PCDHB13 | BCAM | 0.343 | |
| SECTM1 | BCAM | 0.337 | |
| SEMA7A | BCAM | 0.335 | 0.052 |
| IGDCC3 | ROBO1 | 0.278 | |
| MT-ND6 | ROBO1 | 0.278 | 0.08 |
| IGDCC3 | PCDHB13 | 0.214 | |
| SECTM1 | IGDCC3 | 0.214 | |
| MT-ND6 | PCDHB13 | 0.214 | |
| SECTM1 | MT-ND6 | 0.214 | |
| ADGRA2 | BCAM | 0.21 | |
| JAM3 | SIRPA | 0.21 | 0.074 |
| MT-ND6 | BCAM | 0.21 | 0.074 |
| IGDCC3 | BCAM | 0.21 | |
| JAM3 | SEMA7A | 0.192 | 0.094 |
| JAM3 | PCDHB13 | 0.146 | |
| JAM3 | ROR1 | 0.143 | 0.092 |
| SECTM1 | JAM3 | 0.108 | |
| BCAM | ROBO1 | 0.081 | 0.048 |
| ROBO1 | SIRPA | 0.079 | 0.08 |
| ROR1 | ROBO1 | 0.078 | 0.13 |
| JAM3 | BCAM | 0.076 | 0.09 |
| SEMA7A | ROBO1 | 0.07 | 0.108 |
| PCDHB13 | ROBO1 | 0.046 | |
| SECTM1 | ROBO1 | 0.043 | |
| JAM3 | ROBO1 | 0.026 | 0.042 |
Related Complexes