hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14273.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IRF9 | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) | 5 | UniProt NCBI |
| STAT2 | Signal transducer and activator of transcription 2 (p113) | 5 | UniProt NCBI |
| WARS2 | Tryptophan--tRNA ligase, mitochondrial (EC 6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS) | 5 | UniProt NCBI |
| GLIPR2 | Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:60 | 1.53774525569e-05 | 0.5 | IRF9 STAT2 | Interferon-stimulated gene factor 3 transcription complex ISGF3 |
| WP:WP2113 | 0.000114838123418 | 0.5 | IRF9 STAT2 | Type III interferon signaling |
| WP:WP4197 | 0.000484429625977 | 0.5 | IRF9 STAT2 | Immune response to tuberculosis |
| WP:WP4868 | 0.000644879603036 | 0.5 | IRF9 STAT2 | Type I interferon induction and signaling during SARS CoV 2 infection |
| WP:WP619 | 0.000894348084449 | 0.5 | IRF9 STAT2 | Type II interferon signaling |
| WP:WP4880 | 0.00103429913449 | 0.5 | IRF9 STAT2 | Host pathogen interaction of human coronaviruses interferon induction |
| WP:WP4912 | 0.00110807642161 | 0.5 | IRF9 STAT2 | SARS coronavirus and innate immunity |
| WP:WP4558 | 0.00151495259867 | 0.5 | IRF9 STAT2 | Overview of interferons mediated signaling pathway |
| WP:WP585 | 0.00324158330579 | 0.5 | IRF9 STAT2 | Interferon type I signaling pathways |
| GO:0070721 | 0.00842684400117 | 0.5 | IRF9 STAT2 | ISGF3 complex |
| KEGG:04625 | 0.00888666878999 | 0.5 | IRF9 STAT2 | C-type lectin receptor signaling pathway |
| KEGG:04620 | 0.00931062778609 | 0.5 | IRF9 STAT2 | Toll-like receptor signaling pathway |
| KEGG:04380 | 0.0162723391924 | 0.5 | IRF9 STAT2 | Osteoclast differentiation |
| REAC:R-HSA-909733 | 0.0186613511621 | 0.5 | IRF9 STAT2 | Interferon alpha/beta signaling |
| KEGG:05162 | 0.0189154103852 | 0.5 | IRF9 STAT2 | Measles |
| WP:WP4630 | 0.01895043011 | 0.5 | IRF9 STAT2 | Measles virus infection |
| KEGG:05160 | 0.0211069184789 | 0.5 | IRF9 STAT2 | Hepatitis C |
| KEGG:04630 | 0.0211069184789 | 0.5 | IRF9 STAT2 | JAK-STAT signaling pathway |
| KEGG:04217 | 0.0230797254414 | 0.5 | IRF9 STAT2 | Necroptosis |
| KEGG:05164 | 0.0254912281659 | 0.5 | IRF9 STAT2 | Influenza A |
| KEGG:04621 | 0.02620193588 | 0.5 | IRF9 STAT2 | NOD-like receptor signaling pathway |
| KEGG:05167 | 0.0346546128597 | 0.5 | IRF9 STAT2 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05169 | 0.0397541089323 | 0.5 | IRF9 STAT2 | Epstein-Barr virus infection |
| HPA:0060852 | 0.0439037308887 | 0.75 | WARS2 STAT2 GLIPR2 | bronchus; ciliated cells (cell body)[>=Medium] |
| KEGG:05171 | 0.049994875911 | 0.5 | IRF9 STAT2 | Coronavirus disease - COVID-19 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IRF9 | STAT2 | 0.999 | 0.218 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IRF9 | WARS2 | 0.989 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IRF9 | GLIPR2 | 0.962 | 0.032 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| GLIPR2 | STAT2 | 0.464 | 0.082 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| WARS2 | STAT2 | 0.143 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only |
| WARS2 | GLIPR2 | 0.009 | 0.108 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| IRF9 | huMAP3_03104.1 huMAP3_14273.1 |
| STAT2 | huMAP3_04314.1 huMAP3_14273.1 |
| WARS2 | huMAP3_03104.1 huMAP3_12700.1 huMAP3_14022.1 huMAP3_14273.1 huMAP3_15190.1 |
| GLIPR2 | huMAP3_03104.1 huMAP3_12658.1 huMAP3_14273.1 huMAP3_14897.1 |