hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14274.1
Complex Portal: CPX-10669
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG16L2 | Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) | 4 | UniProt NCBI |
| RAB33A | Ras-related protein Rab-33A (Small GTP-binding protein S10) | 5 | UniProt NCBI |
| ATG16L1 | Autophagy-related protein 16-1 (APG16-like 1) | 5 | UniProt NCBI |
| SWSAP1 | ATPase SWSAP1 (SWIM-type zinc finger 7-associated protein 1) (SWS1-associated protein 1) (ZSWIM7-associated protein 1) (ZSWIM7AP1) | 5 | UniProt NCBI |
| ZSWIM7 | Zinc finger SWIM domain-containing protein 7 (SWIM domain-containing and Srs2-interacting protein 1 homolog) (SWIM-type zinc finger domain-containing protein 7) | 5 | UniProt NCBI |
| RAB33B | Ras-related protein Rab-33B | 5 | UniProt NCBI |
| WIPI2 | WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) | 5 | UniProt NCBI |
| ATG12 | Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) | 5 | UniProt NCBI |
| TECPR1 | Tectonin beta-propeller repeat-containing protein 1 | 5 | UniProt NCBI |
| ATG5 | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) | 5 | UniProt NCBI |
| RAB19 | Ras-related protein Rab-19 | 4 | UniProt NCBI |
| ATG3 | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | 5 | UniProt NCBI |
| KAZN | Kazrin | 5 | UniProt NCBI |
| SPIDR | DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0034274 | 1.08105219171e-10 | 0.357142857143 | ATG12 ATG3 ATG5 ATG16L2 ATG16L1 | Atg12-Atg5-Atg16 complex |
| WP:WP4863 | 3.57635646136e-10 | 0.357142857143 | ATG12 ATG3 ATG5 ATG16L2 ATG16L1 | Host pathogen interaction of human coronaviruses autophagy |
| KEGG:04140 | 2.47242396084e-09 | 0.5 | RAB33B WIPI2 ATG5 ATG16L1 ATG3 ATG12 ATG16L2 | Autophagy - animal |
| KEGG:04136 | 2.82107024753e-09 | 0.357142857143 | ATG12 ATG3 ATG5 ATG16L1 WIPI2 | Autophagy - other |
| WP:WP4923 | 4.08126468556e-09 | 0.357142857143 | ATG12 ATG3 ATG5 ATG16L1 WIPI2 | Autophagy |
| GO:0000407 | 9.94091378428e-09 | 0.428571428571 | WIPI2 ATG5 ATG16L1 ATG3 ATG12 ATG16L2 | phagophore assembly site |
| WP:WP4577 | 2.71569765967e-08 | 0.357142857143 | ATG12 ATG3 ATG5 ATG16L1 WIPI2 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| GO:0034045 | 5.38571406773e-08 | 0.357142857143 | ATG12 ATG5 WIPI2 ATG16L2 ATG16L1 | phagophore assembly site membrane |
| GO:0000045 | 6.9819761811e-08 | 0.5 | RAB19 ATG5 ATG16L1 ATG3 ATG16L2 ATG12 WIPI2 | autophagosome assembly |
| GO:1905037 | 9.36105002898e-08 | 0.5 | RAB19 ATG5 ATG16L1 ATG3 ATG16L2 ATG12 WIPI2 | autophagosome organization |
| WP:WP2509 | 4.44705752064e-07 | 0.285714285714 | ATG12 ATG3 ATG16L1 ATG5 | Nanoparticle triggered autophagic cell death |
| GO:0016236 | 1.82374149684e-06 | 0.571428571429 | TECPR1 ATG5 ATG16L1 RAB19 ATG3 ATG16L2 ATG12 WIPI2 | macroautophagy |
| GO:0007033 | 6.3453724942e-06 | 0.5 | RAB19 ATG5 ATG16L1 ATG3 ATG16L2 ATG12 WIPI2 | vacuole organization |
| REAC:R-HSA-1632852 | 2.32396682043e-05 | 0.357142857143 | ATG12 ATG3 ATG5 ATG16L1 WIPI2 | Macroautophagy |
| REAC:R-HSA-9612973 | 4.08188211752e-05 | 0.357142857143 | ATG12 ATG3 ATG5 ATG16L1 WIPI2 | Autophagy |
| WP:WP5205 | 4.82760460331e-05 | 0.285714285714 | ATG12 ATG3 ATG16L1 ATG5 | Clock controlled autophagy in bone metabolism |
| GO:0044804 | 6.22418587116e-05 | 0.285714285714 | ATG12 ATG3 WIPI2 ATG5 | nucleophagy |
| KEGG:05131 | 8.592110458e-05 | 0.357142857143 | ATG12 TECPR1 ATG5 ATG16L1 WIPI2 | Shigellosis |
| GO:0061919 | 9.19520064975e-05 | 0.571428571429 | TECPR1 ATG5 ATG16L1 RAB19 ATG3 ATG16L2 ATG12 WIPI2 | process utilizing autophagic mechanism |
| GO:0006914 | 9.19520064975e-05 | 0.571428571429 | TECPR1 ATG5 ATG16L1 RAB19 ATG3 ATG16L2 ATG12 WIPI2 | autophagy |
| GO:0005776 | 0.00032110097812 | 0.357142857143 | ATG12 TECPR1 ATG5 ATG16L2 ATG16L1 | autophagosome |
| WP:WP5420 | 0.000357550345627 | 0.357142857143 | ATG12 ATG3 ATG5 ATG16L1 WIPI2 | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-8934903 | 0.00668012550606 | 0.142857142857 | ATG12 ATG5 | Receptor Mediated Mitophagy |
| REAC:R-HSA-8873719 | 0.00719016070478 | 0.214285714286 | RAB33A RAB19 RAB33B | RAB geranylgeranylation |
| KEGG:04621 | 0.0182377844069 | 0.214285714286 | ATG12 ATG16L1 ATG5 | NOD-like receptor signaling pathway |
| GO:1901096 | 0.0194497700986 | 0.214285714286 | ATG12 TECPR1 ATG5 | regulation of autophagosome maturation |
| GO:0000422 | 0.0379796902047 | 0.285714285714 | ATG12 ATG3 WIPI2 ATG5 | autophagy of mitochondrion |
| GO:0039689 | 0.0426062655276 | 0.142857142857 | ATG16L2 ATG16L1 | negative stranded viral RNA replication |
| GO:0097196 | 0.0426062655276 | 0.142857142857 | SWSAP1 ZSWIM7 | Shu complex |
| GO:0019776 | 0.0426062655276 | 0.142857142857 | ATG5 ATG3 | Atg8-family ligase activity |
| REAC:R-HSA-5205685 | 0.049745617661 | 0.142857142857 | ATG12 ATG5 | PINK1-PRKN Mediated Mitophagy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ATG5 | ATG16L1 | 1.0 | 0.128 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SWSAP1 | ZSWIM7 | 1.0 |
mutually_exclusive (Q9H082)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ATG5 | RAB33A | 0.999 | 0.178 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG5 | TECPR1 | 0.999 | 0.09 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG5 | ATG12 | 0.999 | 0.442 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| RAB33B | ATG5 | 0.999 | 0.14 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAB33A | ATG16L1 | 0.999 | 0.064 |
mutually_exclusive (Q9H082)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAB33B | RAB33A | 0.998 | 0.106 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG12 | RAB33A | 0.998 | 0.144 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATG16L2 | ATG5 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB33B | ATG16L1 | 0.998 | 0.0448888888889 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RAB33B | ATG12 | 0.998 | 0.118 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG12 | ATG3 | 0.998 | 0.23475 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPIDR | SWSAP1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SWSAP1 | RAB33B | 0.996 |
mutually_exclusive (Q19AV6)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZSWIM7 | RAB33B | 0.993 |
mutually_exclusive (Q6NVH7)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB33A | RAB19 | 0.988 | 0.044 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATG12 | ATG16L1 | 0.986 | 0.162761904762 |
mutually_exclusive (Q9H082)
|
bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SPIDR | ZSWIM7 | 0.984 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| ATG5 | ATG3 | 0.984 | 0.072 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ATG16L2 | TECPR1 | 0.946 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_WMM WMM_only | |
| ATG3 | ATG16L1 | 0.942 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SWSAP1 | RAB33A | 0.924 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ATG16L2 | ATG16L1 | 0.916 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_WMM WMM_only | |
| TECPR1 | ATG16L1 | 0.916 | 0.056 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_WMM WMM_only |
| ATG5 | KAZN | 0.909 | 0.088 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ZSWIM7 | RAB33A | 0.902 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ATG16L1 | WIPI2 | 0.893 | 0.044 |
mutually_exclusive (Q9H1Y0)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| KAZN | ATG16L1 | 0.892 | 0.078 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATG5 | WIPI2 | 0.886 | 0.082 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ATG16L2 | ATG12 | 0.779 |
structurally_consistent (Q9H1Y0)
|
bioplex3_WMM WMM_only | |
| ATG12 | TECPR1 | 0.779 | 0.134 | bioplex3_WMM WMM_only | |
| SWSAP1 | ATG16L1 | 0.467 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| SWSAP1 | ATG5 | 0.431 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ZSWIM7 | ATG12 | 0.401 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| SWSAP1 | ATG12 | 0.389 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ZSWIM7 | ATG16L1 | 0.356 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ZSWIM7 | ATG5 | 0.356 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only | |
| ATG12 | RAB19 | 0.278 | 0.17 |
structurally_consistent (Q9H082)
|
bioplex3_WMM WMM_only |
| RAB33B | RAB19 | 0.25 | 0.12 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| ATG5 | RAB19 | 0.25 | 0.124 | bioplex3_WMM WMM_only | |
| ATG16L1 | RAB19 | 0.25 | 0.066 |
mutually_exclusive (Q9H082)
|
bioplex3_WMM WMM_only |
| ATG3 | WIPI2 | 0.002 | 0.092 |
mutually_exclusive (Q9H1Y0)
|
youn_WMM gupta_WMM WMM_only |
Related Complexes