hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
SMPD3	Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II)	5	UniProt NCBI
TMEM135	Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52)	4	UniProt NCBI
ANXA4	Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II)	5	UniProt NCBI
CBR3	Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) (Quinone reductase CBR3) (EC 1.6.5.10) (Short chain dehydrogenase/reductase family 21C member 2)	5	UniProt NCBI
CYP2E1	Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J)	5	UniProt NCBI
CBR1	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:00590	0.00509527283003	0.4	CYP2E1 CBR3	Arachidonic acid metabolism
KEGG:00980	0.00771708586936	0.4	CYP2E1 CBR3	Metabolism of xenobiotics by cytochrome P450
WP:WP3627	0.0214895895832	0.2	CYP2E1	Gut liver indole metabolism
WP:WP3666	0.0214895895832	0.2	CYP2E1	Metabolism of dichloroethylene by CYP450
WP:WP4233	0.0214895895832	0.2	CYP2E1	Acrylamide biotransformation and exposure biomarkers
WP:WP2816	0.0429732972479	0.2	CYP2E1	Felbamate metabolism
REAC:R-HSA-211945	0.0440242300692	0.4	CYP2E1 CBR3	Phase I - Functionalization of compounds

Protein 1	Protein 2	Score	ProteomeHD	Evidence
CBR3	CBR1	1.0	0.106	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction
TMEM135	SMPD3	0.979	0.122	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
SMPD3	CBR1	0.818	0.118	bioplex3_HEK293 bioplex () bioplex3_WMM
SMPD3	CBR3	0.805	0.07	bioplex3_WMM WMM_only
CBR1	ANXA4	0.801	0.124	bioplex () bioplex_WMM bioplex3_WMM fraction treiber_WMM
CBR1	CYP2E1	0.801		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CBR3	ANXA4	0.733	0.046	bioplex_WMM bioplex3_WMM fraction
SMPD3	ANXA4	0.374	0.128	bioplex_WMM bioplex3_WMM WMM_only
TMEM135	ANXA4	0.01	0.042	bioplex3_HCT116 WMM_only