hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14291.1
Complex Portal: CPX-15530
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INTS3 | Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) | 5 | UniProt NCBI |
| TXLNG | Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5) | 5 | UniProt NCBI |
| NABP2 | SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1) | 5 | UniProt NCBI |
| USP28 | Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28) | 5 | UniProt NCBI |
| NABP1 | SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2) | 5 | UniProt NCBI |
| INTS6L | Integrator complex subunit 6-like (Protein DDX26B) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070876 | 7.68841921772e-06 | 0.5 | INTS3 NABP1 NABP2 | SOSS complex |
| REAC:R-HSA-6807505 | 0.000417052782963 | 0.5 | INTS3 NABP1 NABP2 | RNA polymerase II transcribes snRNA genes |
| GO:0010212 | 0.000792088897246 | 0.666666666667 | INTS3 NABP1 USP28 NABP2 | response to ionizing radiation |
| GO:0000075 | 0.0112661365493 | 0.666666666667 | INTS3 NABP1 USP28 NABP2 | cell cycle checkpoint signaling |
| GO:0010564 | 0.0221505086962 | 0.833333333333 | INTS3 USP28 NABP1 NABP2 TXLNG | regulation of cell cycle process |
| GO:1901988 | 0.0265218418455 | 0.666666666667 | INTS3 NABP1 USP28 NABP2 | negative regulation of cell cycle phase transition |
| GO:0044818 | 0.0289892662643 | 0.5 | INTS3 NABP1 NABP2 | mitotic G2/M transition checkpoint |
| GO:0010948 | 0.0492990715564 | 0.666666666667 | INTS3 NABP1 USP28 NABP2 | negative regulation of cell cycle process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NABP2 | INTS3 | 1.0 | 0.33 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction | |
| NABP2 | INTS6L | 0.978 | 0.056 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| INTS3 | TXLNG | 0.932 | 0.086 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| NABP2 | USP28 | 0.918 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| INTS3 | NABP1 | 0.894 | 0.24 | hein_WMM hein () | |
| INTS3 | USP28 | 0.885 | 0.056 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| INTS6L | INTS3 | 0.761 | 0.092 | bioplex3_WMM WMM_only | |
| TXLNG | USP28 | 0.006 | 0.054 | gupta_WMM WMM_only |
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