hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14302.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CHL1 | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | 5 | UniProt NCBI |
| ANK1 | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | 5 | UniProt NCBI |
| PIKFYVE | 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Serine-protein kinase PIKFYVE) (EC 2.7.11.1) | 5 | UniProt NCBI |
| FIG4 | Polyphosphoinositide phosphatase (EC 3.1.3.-) (EC 3.1.3.36) (EC 3.1.3.86) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3) (Serine-protein phosphatase FIG4) (EC 3.1.3.16) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6186 | 1.02521027753e-05 | 0.666666666667 | PIKFYVE FIG4 | ArPIKfyve-Sac3-Sph1 complex |
| REAC:R-HSA-1660517 | 0.000374861161166 | 0.666666666667 | PIKFYVE FIG4 | Synthesis of PIPs at the late endosome membrane |
| REAC:R-HSA-1660516 | 0.000715513386354 | 0.666666666667 | PIKFYVE FIG4 | Synthesis of PIPs at the early endosome membrane |
| REAC:R-HSA-1660514 | 0.000817692256233 | 0.666666666667 | PIKFYVE FIG4 | Synthesis of PIPs at the Golgi membrane |
| WP:WP5411 | 0.000973512535349 | 0.666666666667 | PIKFYVE FIG4 | Phosphatidyl inositol phosphate pathway |
| KEGG:00562 | 0.00158324752529 | 0.666666666667 | PIKFYVE FIG4 | Inositol phosphate metabolism |
| GO:0043813 | 0.0140440992017 | 0.666666666667 | PIKFYVE FIG4 | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity |
| REAC:R-HSA-1483255 | 0.017372320015 | 0.666666666667 | PIKFYVE FIG4 | PI Metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FIG4 | PIKFYVE | 0.999 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CHL1 | ANK1 | 0.994 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FIG4 | ANK1 | 0.878 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PIKFYVE | ANK1 | 0.847 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
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