hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14311.1

Complex Portal: CPX-21582

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
SERHL2	Serine hydrolase-like protein 2 (EC 3.1.-.-)	4	UniProt NCBI
LRRC4	Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein BAG) (Nasopharyngeal carcinoma-associated gene 14 protein) (Netrin-G2 ligand) (NGL-2)	5	UniProt NCBI
WDR17	WD repeat-containing protein 17	2	UniProt NCBI
MICB	MHC class I polypeptide-related sequence B (MIC-B)	5	UniProt NCBI
TUBB6	Tubulin beta-6 chain (Tubulin beta class V)	5	UniProt NCBI
TUBB2B	Tubulin beta-2B chain	5	UniProt NCBI
TUBB2A	Tubulin beta-2A chain (Tubulin beta class IIa)	5	UniProt NCBI
TTC5	Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Protein Strap)	5	UniProt NCBI
EML1	Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1)	5	UniProt NCBI
EML4	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120)	5	UniProt NCBI
ARL2	ADP-ribosylation factor-like protein 2	5	UniProt NCBI
SPACA9	Sperm acrosome-associated protein 9	5	UniProt NCBI
EML6	Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like)	3	UniProt NCBI
FAS	Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)	5	UniProt NCBI
TBCD	Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D)	5	UniProt NCBI
EML2	Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-389977	5.39266706195e-09	0.333333333333	TUBB2A TBCD ARL2 TUBB6 TUBB2B	Post-chaperonin tubulin folding pathway
REAC:R-HSA-391251	7.57634428e-06	0.333333333333	TUBB2A TBCD ARL2 TUBB6 TUBB2B	Protein folding
GO:0000226	1.09934743231e-05	0.6	EML1 EML4 TBCD TUBB2B SPACA9 TUBB2A EML2 TUBB6 ARL2	microtubule cytoskeleton organization
CORUM:6697	4.77291996201e-05	0.133333333333	TBCD ARL2	ARL2-TBCD complex
CORUM:6455	4.77291996201e-05	0.133333333333	TBCD ARL2	ARL2-TBCD complex
CORUM:6715	0.000143102677271	0.133333333333	TBCD ARL2	TBCD-ARL2-tubulin(beta)-TBCE complex
CORUM:6713	0.000143102677271	0.133333333333	TBCD ARL2	TBCD-ARL2-tubulin(beta) complex
GO:0005874	0.000202852388413	0.466666666667	EML1 EML4 TBCD TUBB2B SPACA9 TUBB2A TUBB6	microtubule
REAC:R-HSA-190840	0.000211731256389	0.2	TUBB2A TUBB6 TUBB2B	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
GO:0007017	0.000225738525689	0.6	EML1 EML4 TBCD TUBB2B SPACA9 TUBB2A EML2 TUBB6 ARL2	microtubule-based process
REAC:R-HSA-190872	0.000251275971072	0.2	TUBB2A TUBB6 TUBB2B	Transport of connexons to the plasma membrane
GO:0072686	0.000348121141611	0.4	EML1 EML4 TUBB2B TUBB2A EML2 TUBB6	mitotic spindle
REAC:R-HSA-389960	0.00059422257382	0.2	TUBB2A TUBB6 TUBB2B	Formation of tubulin folding intermediates by CCT/TriC
REAC:R-HSA-9619483	0.00059422257382	0.2	TUBB2A TUBB6 TUBB2B	Activation of AMPK downstream of NMDARs
REAC:R-HSA-389957	0.000754765187593	0.2	TUBB2A TUBB6 TUBB2B	Prefoldin mediated transfer of substrate to CCT/TriC
REAC:R-HSA-190861	0.000844816170799	0.2	TUBB2A TUBB6 TUBB2B	Gap junction assembly
REAC:R-HSA-9668328	0.000941714373748	0.2	TUBB2A TUBB6 TUBB2B	Sealing of the nuclear envelope (NE) by ESCRT-III
REAC:R-HSA-5626467	0.000941714373748	0.2	TUBB2A TUBB6 TUBB2B	RHO GTPases activate IQGAPs
REAC:R-HSA-389958	0.00127593721539	0.2	TUBB2A TUBB6 TUBB2B	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
REAC:R-HSA-9648025	0.00129662004071	0.266666666667	TUBB2A EML4 TUBB6 TUBB2B	EML4 and NUDC in mitotic spindle formation
WP:WP2272	0.00174054162173	0.2	TUBB2A TUBB6 TUBB2B	Pathogenic Escherichia coli infection
REAC:R-HSA-8955332	0.00216211130131	0.2	TUBB2A TUBB6 TUBB2B	Carboxyterminal post-translational modifications of tubulin
REAC:R-HSA-9609736	0.00216211130131	0.2	TUBB2A TUBB6 TUBB2B	Assembly and cell surface presentation of NMDA receptors
REAC:R-HSA-190828	0.00234084387286	0.2	TUBB2A TUBB6 TUBB2B	Gap junction trafficking
REAC:R-HSA-157858	0.00252908256532	0.2	TUBB2A TUBB6 TUBB2B	Gap junction trafficking and regulation
REAC:R-HSA-9646399	0.00272706541831	0.2	TUBB2A TUBB6 TUBB2B	Aggrephagy
KEGG:04540	0.00273323184262	0.2	TUBB2A TUBB6 TUBB2B	Gap junction
REAC:R-HSA-437239	0.00387143089567	0.2	TUBB2A TUBB6 TUBB2B	Recycling pathway of L1
GO:0099513	0.00399446327228	0.466666666667	EML1 EML4 TBCD TUBB2B SPACA9 TUBB2A TUBB6	polymeric cytoskeletal fiber
WP:WP2359	0.00467938914103	0.2	TUBB2A TUBB6 TUBB2B	Parkin ubiquitin proteasomal system pathway
REAC:R-HSA-6811436	0.00498637410589	0.2	TUBB2A TUBB6 TUBB2B	COPI-independent Golgi-to-ER retrograde traffic
REAC:R-HSA-5620924	0.00529475720887	0.2	TUBB2A TUBB6 TUBB2B	Intraflagellar transport
REAC:R-HSA-3371497	0.00561546291409	0.2	TUBB2A TUBB6 TUBB2B	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
GO:0015630	0.00614920858857	0.6	EML1 EML4 TBCD TUBB2B SPACA9 TUBB2A EML2 TUBB6 ARL2	microtubule cytoskeleton
REAC:R-HSA-983189	0.00629476470124	0.2	TUBB2A TUBB6 TUBB2B	Kinesins
REAC:R-HSA-68877	0.011192804052	0.266666666667	TUBB2A EML4 TUBB6 TUBB2B	Mitotic Prometaphase
REAC:R-HSA-2995410	0.012060281808	0.2	TUBB2A TUBB6 TUBB2B	Nuclear Envelope (NE) Reassembly
GO:0007010	0.0125979218594	0.6	EML1 EML4 TBCD TUBB2B SPACA9 TUBB2A EML2 TUBB6 ARL2	cytoskeleton organization
REAC:R-HSA-438064	0.0126091324159	0.2	TUBB2A TUBB6 TUBB2B	Post NMDA receptor activation events
REAC:R-HSA-1445148	0.0131741483871	0.2	TUBB2A TUBB6 TUBB2B	Translocation of SLC2A4 (GLUT4) to the plasma membrane
GO:0015631	0.0140810782836	0.4	EML1 EML4 TBCD EML6 EML2 SPACA9	tubulin binding
GO:0005819	0.0158479761696	0.4	EML1 EML4 TUBB2B TUBB2A EML2 TUBB6	spindle
REAC:R-HSA-9663891	0.0169160381413	0.2	TUBB2A TUBB6 TUBB2B	Selective autophagy
KEGG:04145	0.0172550534844	0.2	TUBB2A TUBB6 TUBB2B	Phagosome
REAC:R-HSA-8852276	0.01760036011	0.2	TUBB2A TUBB6 TUBB2B	The role of GTSE1 in G2/M progression after G2 checkpoint
REAC:R-HSA-442755	0.0205189573309	0.2	TUBB2A TUBB6 TUBB2B	Activation of NMDA receptors and postsynaptic events
REAC:R-HSA-390466	0.0245912508857	0.2	TUBB2A TUBB6 TUBB2B	Chaperonin-mediated protein folding
GO:0099512	0.0277276557374	0.466666666667	EML1 EML4 TBCD TUBB2B SPACA9 TUBB2A TUBB6	supramolecular fiber
REAC:R-HSA-380320	0.0291595037204	0.2	TUBB2A TUBB6 TUBB2B	Recruitment of NuMA to mitotic centrosomes
GO:0099081	0.030170625806	0.466666666667	EML1 EML4 TBCD TUBB2B SPACA9 TUBB2A TUBB6	supramolecular polymer
KEGG:04814	0.0314446246238	0.2	TUBB2A TUBB6 TUBB2B	Motor proteins
REAC:R-HSA-6811434	0.0321494421448	0.2	TUBB2A TUBB6 TUBB2B	COPI-dependent Golgi-to-ER retrograde traffic
KEGG:05130	0.0331739021941	0.2	TUBB2A TUBB6 TUBB2B	Pathogenic Escherichia coli infection
REAC:R-HSA-6807878	0.0353329800227	0.2	TUBB2A TUBB6 TUBB2B	COPI-mediated anterograde transport
REAC:R-HSA-373760	0.0423030455987	0.2	TUBB2A TUBB6 TUBB2B	L1CAM interactions
REAC:R-HSA-5610787	0.0461005561217	0.2	TUBB2A TUBB6 TUBB2B	Hedgehog 'off' state
HPA:0060872	0.0465646326291	0.266666666667	WDR17 TBCD ARL2 SPACA9	bronchus; ciliated cells (ciliary rootlets)[>=Medium]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
EML4	EML1	1.0	0.088	mutually_exclusive (Q13509)
ARL2	TBCD	1.0	0.2
TUBB2A	TUBB6	0.999	0.526	structurally_consistent (dimer)
TUBB2B	TBCD	0.998	0.286	structurally_consistent (dimer)
EML1	EML2	0.997
TUBB2B	FAS	0.997	0.166
TUBB2A	FAS	0.995	0.204	structurally_consistent (P04350) structurally_consistent (dimer)
TUBB2A	TBCD	0.995	0.148
ARL2	TUBB2B	0.991	0.244	structurally_consistent (dimer)
TUBB2A	TTC5	0.991	0.188	structurally_consistent (dimer)
EML4	EML2	0.99		mutually_exclusive (Q9BVA1)
TUBB2A	EML2	0.99		structurally_consistent (dimer)
TUBB2B	TTC5	0.99	0.184
TUBB2A	ARL2	0.989	0.164
TUBB6	EML2	0.987		structurally_consistent (Q3ZCM7)
EML2	TUBB2B	0.982		structurally_consistent (dimer)
TUBB6	TUBB2B	0.976	0.63	structurally_consistent (dimer)
TUBB6	FAS	0.975	0.224768
TUBB6	TTC5	0.966	0.198
ARL2	EML2	0.963
TUBB2A	MICB	0.963	0.108
EML2	FAS	0.957
FAS	TBCD	0.956	0.149666666667
EML6	TUBB2B	0.953
TUBB2A	TUBB2B	0.94	0.47	structurally_consistent (dimer)
TUBB2B	SPACA9	0.934		structurally_consistent (dimer)
ARL2	TTC5	0.934	0.064
MICB	TUBB6	0.919	0.306
TUBB2A	EML4	0.917	0.098
ARL2	WDR17	0.915
LRRC4	TBCD	0.912
EML2	TBCD	0.906
ARL2	FAS	0.906	0.166
SERHL2	MICB	0.9
TTC5	FAS	0.899	0.11
EML2	TTC5	0.884
MICB	FAS	0.882	0.146
EML1	TUBB2B	0.881	0.218
MICB	TUBB2B	0.88	0.19
EML4	TTC5	0.871	0.026
TUBB2A	EML1	0.837	0.136
ARL2	EML1	0.834	0.012
EML6	EML2	0.81
EML1	TTC5	0.789	0.078
TTC5	TBCD	0.739	0.036
ARL2	TUBB6	0.716	0.1803
EML4	TBCD	0.701	0.102
EML4	TUBB2B	0.674	0.198	mutually_exclusive (Q13509) structurally_consistent (dimer)
EML1	FAS	0.433	0.034
EML1	TBCD	0.423	0.076
ARL2	EML4	0.383	0.106
MICB	TTC5	0.348	0.042
MICB	EML2	0.343
MICB	ARL2	0.311	0.114
EML6	TUBB6	0.307
ARL2	EML6	0.3
EML6	EML1	0.291
EML6	EML4	0.251
TUBB6	TBCD	0.243	0.252
EML6	TBCD	0.195
EML6	FAS	0.176
MICB	TBCD	0.174	0.076
EML6	TTC5	0.157
MICB	EML1	0.107	0.046
EML4	FAS	0.098	0.244
TUBB6	EML1	0.095	0.164
TBCD	WDR17	0.076
TUBB2A	EML6	0.075
MICB	EML4	0.073	0.072
TUBB6	EML4	0.045	0.14	mutually_exclusive (Q9BVA1)
MICB	EML6	0.03
TUBB6	WDR17	0.019
TUBB2A	WDR17	0.013
TUBB2B	WDR17	0.013
SERHL2	TUBB2B	0.012
LRRC4	TUBB6	0.011
LRRC4	TUBB2B	0.01
TUBB2A	LRRC4	0.006
TUBB6	SPACA9	0.006		structurally_consistent (Q9BVA1)
TUBB2A	SERHL2	0.004
SERHL2	TUBB6	0.004
TUBB2A	SPACA9	0.003		structurally_consistent (Q9BVA1)

Related Complexes

Genename	Complexes
SERHL2	huMAP3_00131.1 huMAP3_02491.1 huMAP3_12767.1 huMAP3_14311.1 huMAP3_14620.1
LRRC4	huMAP3_02144.1 huMAP3_10081.1 huMAP3_12068.1 huMAP3_14311.1 huMAP3_15023.1
WDR17	huMAP3_13133.1 huMAP3_14311.1 huMAP3_14884.1
MICB	huMAP3_00504.1 huMAP3_04476.1 huMAP3_05459.1 huMAP3_07134.1 huMAP3_08606.1 huMAP3_09753.1 huMAP3_14311.1 huMAP3_14620.1
TUBB6	huMAP3_03106.1 huMAP3_04859.1 huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1
TUBB2B	huMAP3_06977.1 huMAP3_08179.1 huMAP3_08402.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1
TUBB2A	huMAP3_00118.1 huMAP3_05787.1 huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1
TTC5	huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1 huMAP3_14884.1
EML1	huMAP3_04397.1 huMAP3_08321.1 huMAP3_09233.1 huMAP3_09835.1 huMAP3_10475.1 huMAP3_14043.1 huMAP3_14311.1 huMAP3_14884.1
EML4	huMAP3_04397.1 huMAP3_08321.1 huMAP3_09233.1 huMAP3_09835.1 huMAP3_10475.1 huMAP3_14043.1 huMAP3_14311.1 huMAP3_14884.1
ARL2	huMAP3_01239.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10142.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_13133.1 huMAP3_14311.1 huMAP3_14884.1
SPACA9	huMAP3_11712.1 huMAP3_12372.1 huMAP3_14311.1
EML6	huMAP3_02722.1 huMAP3_08179.1 huMAP3_08402.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14043.1 huMAP3_14311.1 huMAP3_14884.1
FAS	huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_12841.1 huMAP3_14311.1
TBCD	huMAP3_06977.1 huMAP3_07544.1 huMAP3_07762.1 huMAP3_07864.1 huMAP3_08179.1 huMAP3_09233.1 huMAP3_09603.1 huMAP3_09670.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14311.1
EML2	huMAP3_04397.1 huMAP3_04859.1 huMAP3_06977.1 huMAP3_07762.1 huMAP3_08321.1 huMAP3_09233.1 huMAP3_09670.1 huMAP3_09835.1 huMAP3_10475.1 huMAP3_10665.1 huMAP3_14043.1 huMAP3_14311.1 huMAP3_14884.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14311.1

Complex Portal: CPX-21582