hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14322.1
Complex Portal: CPX-25382
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SAA2 | Serum amyloid A-2 protein (SAA2) [Cleaved into: Amyloid A2 protein (AA2)] | 5 | UniProt NCBI |
| PON3 | Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) | 5 | UniProt NCBI |
| PON1 | Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) | 5 | UniProt NCBI |
| UBE2U | Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP136 | 5.36057998926e-05 | 0.5 | PON1 PON3 | Phase I biotransformations non P450 |
| REAC:R-HSA-2142688 | 0.000215205765992 | 0.5 | PON1 PON3 | Synthesis of 5-eicosatetraenoic acids |
| REAC:R-HSA-9754706 | 0.000286914834749 | 0.5 | PON1 PON3 | Atorvastatin ADME |
| REAC:R-HSA-2142753 | 0.0115164156767 | 0.5 | PON1 PON3 | Arachidonic acid metabolism |
| HP:0009067 | 0.0176079483787 | 0.5 | PON1 PON3 | Progressive spinal muscular atrophy |
| HP:0008955 | 0.0198386649826 | 0.5 | PON1 PON3 | Progressive distal muscular atrophy |
| HP:0025425 | 0.0234332085093 | 0.5 | PON1 PON3 | Laryngospasm |
| HP:0033683 | 0.0234332085093 | 0.5 | PON1 PON3 | Jaw hyperreflexia |
| HP:0030195 | 0.0259951101914 | 0.5 | PON1 PON3 | Fatigable weakness of swallowing muscles |
| HP:0025424 | 0.0315158796726 | 0.5 | PON1 PON3 | Abnormal larynx physiology |
| HP:0012473 | 0.0315158796726 | 0.5 | PON1 PON3 | Tongue atrophy |
| REAC:R-HSA-9748784 | 0.0329793636325 | 0.5 | PON1 PON3 | Drug ADME |
| HP:0007354 | 0.034474601612 | 0.5 | PON1 PON3 | Amyotrophic lateral sclerosis |
| HP:0002145 | 0.0375654511359 | 0.5 | PON1 PON3 | Frontotemporal dementia |
| HP:0000217 | 0.040788355352 | 0.5 | PON1 PON3 | Xerostomia |
| HP:0007269 | 0.040788355352 | 0.5 | PON1 PON3 | Spinal muscular atrophy |
| GO:0004064 | 0.042122686785 | 0.5 | PON1 PON3 | arylesterase activity |
| HP:0030196 | 0.0458701548093 | 0.5 | PON1 PON3 | Fatigable weakness of respiratory muscles |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PON3 | PON1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| UBE2U | SAA2 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBE2U | PON1 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SAA2 | PON1 | 0.881 | bioplex3_WMM WMM_only |
Related Complexes